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Pediatric Patient-Derived-Xenograft development in MAPPYACTS – international pediatric cancer precision medicine trial in relapsed and refractory tumors

Pediatric patients with recurrent and refractory cancers are in most need for new treatments. This study developed patient-derived-xenograft (PDX) models within the European MAPPYACTS cancer precision medicine trial (NCT02613962). To date, 131 PDX models were established following heterotopical and/or orthotopical implantation in immunocompromised mice: 76 sarcomas, 25 other solid tumors, 12 central nervous system tumors, 15 acute leukemias, and 3 lymphomas. PDX establishment rate was 43%. Histology, whole exome and RNA sequencing revealed a high concordance with the primary patient’s tumor profile, human leukocyte-antigen characteristics and specific metabolic pathway signatures. A detailed patient molecular characterization, including specific mutations prioritized in the clinical molecular tumor boards are provided. Ninety models were shared with the IMI2 ITCC Paediatric Preclinical Proof-of-concept Platform (IMI2 ITCC-P4) for further exploitation. This new PDX biobank of unique recurrent childhood cancers provides an essential support for basic and translational research and new treatments development in advanced pediatric malignancies.

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Data Access Policy for “Pediatric Patient-Derived-Xenograft development in MAPPYACTS – international pediatric cancer precision medicine trial in relapsed and refractory tumors” data

Data Access Policy for “Pediatric Patient-Derived-Xenograft development in MAPPYACTS – international pediatric cancer precision medicine trial in relapsed and refractory tumors ” data Preamble Gustave Roussy set up a Data Access Committee (DAC) to process requests for access to the “Pediatric Patient-Derived-Xenograft development in MAPPYACTS – international pediatric cancer precision medicine trial in relapsed and refractory tumors” data. Article I. Data Access Committee Article I.1 Composition Gustave Roussy's DAC is composed of Birgit Geoerger, Gilles Vassal and Gudrun Schleiermacher. Article I.1 Missions Gustave Roussy's DAC is responsible for authorizing access to the data. Article II. Request for access to data Article II.1 Composition of the application file The data access request requires: - A summary of the study (synopsis template on github) : it can be very light: we just need to know the general question that is going to be addressed; - The CNIL declaration (on github) : we can take care of the submission part to the CNIL, once we receive it; - The standard contractual clauses signed (on github) if your country is located outside of the European Community (check if your country is concerned : https://www.cnil.fr/en/data-protection-around-the-world) - The opinion issued by an Institution Review Board / or ethical committee that evaluated the project and the composition of the committee(s), if any; - The confidentiality form (on github); - The documentation necessary to demonstrate compliance with all its data protection and security obligations (a security charter); - This data access policy signed Article II.2 Application procedures The request for access to the data is free. It is done by mail to the following addresses Birgit.geoerger@gustaveroussy.fr Gilles.vassal@gustaveroussy.fr Article II.3. Examination of applications Following the filing of the file with the DAC, the latter: - verify its good orientation and completeness. Otherwise, the DAC will contact the requester for further information; - instruct the request for access to the data within one month after receiving the complete file. This time is given as an indication. Article III. Conditions of use of the data The applicants undertake to respect all the following measures and to have them respected by their staff as well as any other person(s) assisting them with the use of the data: - To collect only data adequate, relevant, limited and strictly necessary to the specific treatment that it with these data; - Do not use the data to which they can access for purposes other than those indicated in the application file; - Disclose this data only to persons duly authorized by reason of their duties and who have been indicated in the data access request file; - Do not make any copy of this data except that it is necessary for the execution of their research; - Take all necessary measures to avoid misuse or fraudulent use of this data; - Ensure that only secure means of communication will be used to transfer this data; - At the end of the research project, to fully restore the data, computer files and any information related to these data. When this task falls within its remit, the applicants undertake to ensure that the persons from whom they collect and / or use the data have been previously informed of the specific treatment that they are carrying out with their data. Article IV. Notification of data breach As soon as it becomes aware of this and within a maximum of twenty-four (24) hours, the requester notifies the DAC of any data breach. The requester provides to the DAC at the time of notification of the incident, or if this is not reasonably possible as soon as possible after the notification of the data breach, the following information regarding their violation: 1) The nature of the data breach; 2) The estimated number of people involved; 3) Categories of the person(s) involved; 4) The categories of Data concerned; 5) The estimated number of Data violated; Measures taken to remedy the data breach, including, measures to limit adverse effects and potential risks. The applicants shall as far as possible assist the DAC in reporting the data breach to the relevant control authorization and / or to the person(s) involved in the data breach. Article V. Data destruction At the end of the search, the applicants undertake, after having made sure of the terms relating to reversibility: - Destroy all data - Return all data to the DAC - Return the data to the subcontractor designated by the DAC The return must be accompanied by the destruction of all data (including copies) in the information systems of the applicant and their collaborators. First and last Name : Facility attached to : Date and place : Signature preceded by the mention ‘I pledge to respect this Data Access Policy or will be subject to legal penalties’

Studies are experimental investigations of a particular phenomenon, e.g., case-control studies on a particular trait or cancer research projects reporting matching cancer normal genomes from patients.

Study ID Study Title Study Type
EGAS00001007327 Other

This table displays only public information pertaining to the files in the dataset. If you wish to access this dataset, please submit a request. If you already have access to these data files, please consult the download documentation.

ID File Type Size Located in
EGAF00008096591 fastq.gz 3.4 GB
EGAF00008096592 fastq.gz 3.7 GB
EGAF00008096593 fastq.gz 1.2 GB
EGAF00008096594 fastq.gz 1.3 GB
EGAF00008096595 fastq.gz 4.2 GB
EGAF00008096596 fastq.gz 4.4 GB
EGAF00008096597 fastq.gz 4.2 GB
EGAF00008096598 fastq.gz 4.4 GB
EGAF00008096599 fastq.gz 4.2 GB
EGAF00008096600 fastq.gz 4.5 GB
EGAF00008096601 fastq.gz 3.6 GB
EGAF00008096602 fastq.gz 3.8 GB
EGAF00008096603 fastq.gz 4.8 GB
EGAF00008096604 fastq.gz 5.0 GB
EGAF00008096605 fastq.gz 3.8 GB
EGAF00008096606 fastq.gz 3.9 GB
EGAF00008096607 fastq.gz 4.0 GB
EGAF00008096608 fastq.gz 4.2 GB
EGAF00008096609 fastq.gz 4.7 GB
EGAF00008096610 fastq.gz 5.0 GB
EGAF00008096611 fastq.gz 5.3 GB
EGAF00008096612 fastq.gz 5.4 GB
EGAF00008096613 fastq.gz 4.1 GB
EGAF00008096614 fastq.gz 4.2 GB
EGAF00008096615 fastq.gz 6.5 GB
EGAF00008096616 fastq.gz 6.8 GB
EGAF00008096617 fastq.gz 3.3 GB
EGAF00008096618 fastq.gz 3.5 GB
EGAF00008096619 fastq.gz 5.8 GB
EGAF00008096620 fastq.gz 5.8 GB
EGAF00008096621 fastq.gz 3.4 GB
EGAF00008096622 fastq.gz 3.5 GB
EGAF00008096623 fastq.gz 5.8 GB
EGAF00008096624 fastq.gz 6.0 GB
EGAF00008096625 fastq.gz 3.7 GB
EGAF00008096626 fastq.gz 3.9 GB
EGAF00008096627 fastq.gz 3.6 GB
EGAF00008096628 fastq.gz 3.8 GB
EGAF00008096629 fastq.gz 3.5 GB
EGAF00008096630 fastq.gz 3.9 GB
EGAF00008096631 fastq.gz 3.7 GB
EGAF00008096632 fastq.gz 3.9 GB
EGAF00008096633 fastq.gz 2.5 GB
EGAF00008096634 fastq.gz 2.7 GB
EGAF00008096635 fastq.gz 3.6 GB
EGAF00008096636 fastq.gz 3.9 GB
EGAF00008096637 fastq.gz 2.8 GB
EGAF00008096638 fastq.gz 3.0 GB
EGAF00008096639 fastq.gz 4.7 GB
EGAF00008096640 fastq.gz 4.8 GB
EGAF00008096641 fastq.gz 3.7 GB
EGAF00008096642 fastq.gz 3.8 GB
EGAF00008096643 fastq.gz 3.9 GB
EGAF00008096644 fastq.gz 4.1 GB
EGAF00008096645 fastq.gz 3.2 GB
EGAF00008096646 fastq.gz 3.4 GB
EGAF00008096647 fastq.gz 4.9 GB
EGAF00008096648 fastq.gz 5.3 GB
EGAF00008096649 fastq.gz 3.8 GB
EGAF00008096650 fastq.gz 4.1 GB
EGAF00008096651 fastq.gz 3.7 GB
EGAF00008096652 fastq.gz 4.0 GB
EGAF00008096653 fastq.gz 3.4 GB
EGAF00008096654 fastq.gz 3.7 GB
EGAF00008096655 fastq.gz 4.0 GB
EGAF00008096656 fastq.gz 4.2 GB
EGAF00008096657 fastq.gz 2.9 GB
EGAF00008096658 fastq.gz 3.1 GB
EGAF00008096659 fastq.gz 3.6 GB
EGAF00008096660 fastq.gz 3.8 GB
EGAF00008096661 fastq.gz 3.9 GB
EGAF00008096662 fastq.gz 4.3 GB
EGAF00008096663 fastq.gz 5.5 GB
EGAF00008096664 fastq.gz 6.0 GB
EGAF00008096665 fastq.gz 4.1 GB
EGAF00008096666 fastq.gz 4.7 GB
EGAF00008096667 fastq.gz 4.1 GB
EGAF00008096668 fastq.gz 4.4 GB
EGAF00008096669 fastq.gz 4.5 GB
EGAF00008096670 fastq.gz 4.8 GB
EGAF00008096671 fastq.gz 3.6 GB
EGAF00008096672 fastq.gz 3.8 GB
EGAF00008096673 fastq.gz 3.3 GB
EGAF00008096674 fastq.gz 3.5 GB
EGAF00008096675 fastq.gz 4.7 GB
EGAF00008096676 fastq.gz 5.0 GB
EGAF00008096677 fastq.gz 3.4 GB
EGAF00008096678 fastq.gz 3.7 GB
EGAF00008096679 fastq.gz 3.5 GB
EGAF00008096680 fastq.gz 3.8 GB
EGAF00008096681 fastq.gz 4.6 GB
EGAF00008096682 fastq.gz 4.6 GB
EGAF00008096683 fastq.gz 3.0 GB
EGAF00008096684 fastq.gz 3.3 GB
EGAF00008096685 fastq.gz 2.8 GB
EGAF00008096686 fastq.gz 2.9 GB
EGAF00008096687 fastq.gz 3.7 GB
EGAF00008096688 fastq.gz 3.9 GB
EGAF00008096689 fastq.gz 3.3 GB
EGAF00008096690 fastq.gz 3.5 GB
EGAF00008096691 fastq.gz 4.2 GB
EGAF00008096692 fastq.gz 4.5 GB
EGAF00008096693 fastq.gz 3.1 GB
EGAF00008096694 fastq.gz 3.2 GB
EGAF00008096695 fastq.gz 4.2 GB
EGAF00008096696 fastq.gz 4.4 GB
EGAF00008096697 fastq.gz 2.4 GB
EGAF00008096698 fastq.gz 2.5 GB
EGAF00008096699 fastq.gz 5.2 GB
EGAF00008096700 fastq.gz 5.2 GB
EGAF00008096701 fastq.gz 3.8 GB
EGAF00008096702 fastq.gz 3.9 GB
EGAF00008096703 fastq.gz 3.6 GB
EGAF00008096704 fastq.gz 3.7 GB
EGAF00008096705 fastq.gz 3.2 GB
EGAF00008096706 fastq.gz 3.3 GB
EGAF00008096707 fastq.gz 3.4 GB
EGAF00008096708 fastq.gz 3.4 GB
EGAF00008096709 fastq.gz 3.1 GB
EGAF00008096710 fastq.gz 3.2 GB
EGAF00008096711 fastq.gz 5.3 GB
EGAF00008096712 fastq.gz 5.5 GB
EGAF00008096713 fastq.gz 2.2 GB
EGAF00008096714 fastq.gz 2.3 GB
EGAF00008096715 fastq.gz 3.5 GB
EGAF00008096716 fastq.gz 3.6 GB
EGAF00008096717 fastq.gz 3.1 GB
EGAF00008096718 fastq.gz 3.2 GB
EGAF00008096721 fastq.gz 3.3 GB
EGAF00008096722 fastq.gz 3.5 GB
EGAF00008096723 fastq.gz 4.2 GB
EGAF00008096724 fastq.gz 4.5 GB
EGAF00008096725 fastq.gz 3.5 GB
EGAF00008096726 fastq.gz 4.1 GB
EGAF00008096727 fastq.gz 3.9 GB
EGAF00008096728 fastq.gz 4.0 GB
EGAF00008096729 fastq.gz 4.0 GB
EGAF00008096730 fastq.gz 4.0 GB
EGAF00008096731 fastq.gz 3.6 GB
EGAF00008096732 fastq.gz 3.6 GB
EGAF00008096733 fastq.gz 3.4 GB
EGAF00008096734 fastq.gz 3.4 GB
EGAF00008096735 fastq.gz 4.2 GB
EGAF00008096736 fastq.gz 4.4 GB
EGAF00008096737 fastq.gz 3.4 GB
EGAF00008096738 fastq.gz 3.5 GB
EGAF00008096739 fastq.gz 5.4 GB
EGAF00008096740 fastq.gz 5.5 GB
EGAF00008096741 fastq.gz 3.6 GB
EGAF00008096742 fastq.gz 3.7 GB
EGAF00008096743 fastq.gz 3.4 GB
EGAF00008096744 fastq.gz 3.4 GB
EGAF00008096745 fastq.gz 4.2 GB
EGAF00008096746 fastq.gz 4.3 GB
EGAF00008096747 fastq.gz 4.1 GB
EGAF00008096748 fastq.gz 4.4 GB
EGAF00008096749 fastq.gz 5.0 GB
EGAF00008096750 fastq.gz 5.4 GB
EGAF00008096751 fastq.gz 3.8 GB
EGAF00008096752 fastq.gz 4.0 GB
EGAF00008096753 fastq.gz 4.2 GB
EGAF00008096754 fastq.gz 4.2 GB
EGAF00008096755 fastq.gz 3.9 GB
EGAF00008096756 fastq.gz 4.0 GB
EGAF00008096757 fastq.gz 3.5 GB
EGAF00008096758 fastq.gz 3.6 GB
EGAF00008096759 fastq.gz 3.6 GB
EGAF00008096760 fastq.gz 3.7 GB
EGAF00008096761 fastq.gz 3.8 GB
EGAF00008096762 fastq.gz 3.9 GB
EGAF00008096763 fastq.gz 3.4 GB
EGAF00008096764 fastq.gz 3.6 GB
EGAF00008096765 fastq.gz 4.2 GB
EGAF00008096766 fastq.gz 4.5 GB
EGAF00008096767 fastq.gz 3.9 GB
EGAF00008096768 fastq.gz 4.1 GB
EGAF00008096769 fastq.gz 4.1 GB
EGAF00008096770 fastq.gz 4.4 GB
EGAF00008096771 fastq.gz 3.5 GB
EGAF00008096772 fastq.gz 3.6 GB
EGAF00008096773 fastq.gz 3.9 GB
EGAF00008096774 fastq.gz 4.1 GB
EGAF00008096775 fastq.gz 4.6 GB
EGAF00008096776 fastq.gz 4.8 GB
EGAF00008096777 fastq.gz 4.0 GB
EGAF00008096778 fastq.gz 4.3 GB
EGAF00008096779 fastq.gz 4.2 GB
EGAF00008096780 fastq.gz 4.5 GB
EGAF00008096781 fastq.gz 4.1 GB
EGAF00008096782 fastq.gz 4.3 GB
EGAF00008096783 fastq.gz 3.5 GB
EGAF00008096784 fastq.gz 3.7 GB
EGAF00008096785 fastq.gz 4.7 GB
EGAF00008096786 fastq.gz 5.0 GB
EGAF00008096787 fastq.gz 5.2 GB
EGAF00008096788 fastq.gz 5.7 GB
EGAF00008096789 fastq.gz 3.8 GB
EGAF00008096790 fastq.gz 4.1 GB
EGAF00008096791 fastq.gz 4.1 GB
EGAF00008096792 fastq.gz 4.3 GB
EGAF00008096793 fastq.gz 4.0 GB
EGAF00008096794 fastq.gz 4.3 GB
EGAF00008096795 fastq.gz 4.2 GB
EGAF00008096796 fastq.gz 4.5 GB
EGAF00008096797 fastq.gz 3.6 GB
EGAF00008096798 fastq.gz 3.8 GB
EGAF00008096799 fastq.gz 3.6 GB
EGAF00008096800 fastq.gz 3.8 GB
EGAF00008096801 fastq.gz 3.7 GB
EGAF00008096802 fastq.gz 3.5 GB
EGAF00008096803 fastq.gz 3.1 GB
EGAF00008096804 fastq.gz 3.6 GB
EGAF00008096805 fastq.gz 4.9 GB
EGAF00008096806 fastq.gz 5.4 GB
EGAF00008096807 fastq.gz 4.6 GB
EGAF00008096808 fastq.gz 4.9 GB
EGAF00008096809 fastq.gz 3.2 GB
EGAF00008096810 fastq.gz 3.5 GB
EGAF00008096811 fastq.gz 3.0 GB
EGAF00008096812 fastq.gz 3.3 GB
EGAF00008096813 fastq.gz 2.5 GB
EGAF00008096814 fastq.gz 2.7 GB
EGAF00008096815 fastq.gz 3.1 GB
EGAF00008096816 fastq.gz 3.4 GB
EGAF00008096817 fastq.gz 3.1 GB
EGAF00008096818 fastq.gz 3.2 GB
EGAF00008096819 fastq.gz 3.4 GB
EGAF00008096820 fastq.gz 3.6 GB
EGAF00008096821 fastq.gz 3.3 GB
EGAF00008096822 fastq.gz 4.2 GB
EGAF00008096823 fastq.gz 3.7 GB
EGAF00008096824 fastq.gz 4.6 GB
EGAF00008096825 fastq.gz 3.7 GB
EGAF00008096826 fastq.gz 4.0 GB
EGAF00008096827 fastq.gz 2.8 GB
EGAF00008096828 fastq.gz 2.9 GB
EGAF00008096829 fastq.gz 3.4 GB
EGAF00008096830 fastq.gz 3.8 GB
EGAF00008096831 fastq.gz 2.5 GB
EGAF00008096832 fastq.gz 2.9 GB
EGAF00008096833 fastq.gz 3.4 GB
EGAF00008096834 fastq.gz 3.7 GB
EGAF00008096835 fastq.gz 3.2 GB
EGAF00008096836 fastq.gz 3.8 GB
EGAF00008096837 fastq.gz 3.4 GB
EGAF00008096838 fastq.gz 4.2 GB
EGAF00008096839 fastq.gz 2.5 GB
EGAF00008096840 fastq.gz 2.7 GB
EGAF00008096841 fastq.gz 3.9 GB
EGAF00008096842 fastq.gz 4.1 GB
EGAF00008096843 fastq.gz 2.8 GB
EGAF00008096844 fastq.gz 3.0 GB
EGAF00008096845 fastq.gz 3.3 GB
EGAF00008096846 fastq.gz 3.5 GB
EGAF00008096847 fastq.gz 3.1 GB
EGAF00008096848 fastq.gz 3.4 GB
EGAF00008096849 fastq.gz 3.3 GB
EGAF00008096850 fastq.gz 3.7 GB
EGAF00008096851 fastq.gz 3.2 GB
EGAF00008096852 fastq.gz 3.5 GB
EGAF00008096853 fastq.gz 2.8 GB
EGAF00008096854 fastq.gz 3.1 GB
EGAF00008096855 fastq.gz 2.8 GB
EGAF00008096856 fastq.gz 3.1 GB
EGAF00008096857 fastq.gz 2.6 GB
EGAF00008096858 fastq.gz 2.8 GB
EGAF00008096859 fastq.gz 2.9 GB
EGAF00008096860 fastq.gz 3.1 GB
EGAF00008096861 fastq.gz 3.2 GB
EGAF00008096862 fastq.gz 3.4 GB
EGAF00008096863 fastq.gz 3.3 GB
EGAF00008096864 fastq.gz 3.6 GB
EGAF00008096865 fastq.gz 3.3 GB
EGAF00008096866 fastq.gz 3.6 GB
EGAF00008096867 fastq.gz 4.3 GB
EGAF00008096868 fastq.gz 4.7 GB
EGAF00008096869 fastq.gz 2.6 GB
EGAF00008096870 fastq.gz 3.1 GB
EGAF00008096871 fastq.gz 4.7 GB
EGAF00008096872 fastq.gz 5.0 GB
EGAF00008096873 fastq.gz 4.9 GB
EGAF00008096874 fastq.gz 5.5 GB
EGAF00008096875 fastq.gz 5.2 GB
EGAF00008096876 fastq.gz 5.9 GB
EGAF00008096877 fastq.gz 5.3 GB
EGAF00008096878 fastq.gz 6.5 GB
EGAF00008096879 fastq.gz 3.4 GB
EGAF00008096880 fastq.gz 3.9 GB
EGAF00008096881 fastq.gz 4.0 GB
EGAF00008096882 fastq.gz 4.5 GB
EGAF00008096883 fastq.gz 2.9 GB
EGAF00008096884 fastq.gz 3.4 GB
EGAF00008096885 fastq.gz 4.4 GB
EGAF00008096886 fastq.gz 5.3 GB
EGAF00008096887 fastq.gz 3.4 GB
EGAF00008096888 fastq.gz 4.1 GB
EGAF00008096889 fastq.gz 3.3 GB
EGAF00008096890 fastq.gz 3.8 GB
EGAF00008096891 fastq.gz 3.5 GB
EGAF00008096892 fastq.gz 4.0 GB
EGAF00008096893 fastq.gz 4.7 GB
EGAF00008096894 fastq.gz 5.8 GB
EGAF00008096895 fastq.gz 4.2 GB
EGAF00008096896 fastq.gz 4.8 GB
EGAF00008096897 fastq.gz 3.9 GB
EGAF00008096898 fastq.gz 4.8 GB
EGAF00008096899 fastq.gz 3.1 GB
EGAF00008096900 fastq.gz 3.2 GB
EGAF00008096901 fastq.gz 4.2 GB
EGAF00008096902 fastq.gz 4.4 GB
EGAF00008096903 fastq.gz 4.7 GB
EGAF00008096904 fastq.gz 4.9 GB
EGAF00008096905 fastq.gz 4.1 GB
EGAF00008096906 fastq.gz 4.2 GB
EGAF00008096907 fastq.gz 2.5 GB
EGAF00008096908 fastq.gz 2.6 GB
EGAF00008096909 fastq.gz 2.7 GB
EGAF00008096910 fastq.gz 2.8 GB
EGAF00008096911 fastq.gz 6.1 GB
EGAF00008096912 fastq.gz 6.4 GB
EGAF00008096913 fastq.gz 3.0 GB
EGAF00008096914 fastq.gz 3.3 GB
EGAF00008096915 fastq.gz 2.4 GB
EGAF00008096916 fastq.gz 2.5 GB
EGAF00008096917 fastq.gz 2.2 GB
EGAF00008096918 fastq.gz 2.3 GB
EGAF00008096919 fastq.gz 2.6 GB
EGAF00008096920 fastq.gz 2.7 GB
EGAF00008096921 fastq.gz 5.2 GB
EGAF00008096922 fastq.gz 5.3 GB
330 Files (1.3 TB)