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Single-cell Transcriptomic and TCR Repertoire Profiling of DENV-specific CD8+ T Cells Across Dengue Disease Severities

This dataset contains single-cell RNA sequencing (Smart-seq2) and paired TCR repertoire data of sorted dengue virus (DENV)-specific CD8⁺ T cells from individuals with differing clinical outcomes: asymptomatic dengue (AD), dengue fever (DF), and dengue hemorrhagic fever (DHF). Samples were obtained from HLA-A11⁺ and HLA-A24⁺ individuals during acute and convalescent phases, with antigen-specific CD8⁺ T cells isolated using HLA tetramers loaded with immunodominant DENV epitopes. The study identifies phenotypically distinct T cell subsets associated with disease severity, TCR avidity, and antigen reactivity to current or prior DENV serotypes. The dataset supports the understanding of CD8⁺ T cell heterogeneity, TCR features, and potential mechanisms of CD8⁺ T cell-mediated protection versus immunopathogenesis in dengue infection.

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Study ID Study Title Study Type
EGAS00001004980 Transcriptome Analysis

This table displays only public information pertaining to the files in the dataset. If you wish to access this dataset, please submit a request. If you already have access to these data files, please consult the download documentation.

ID File Type Size Quality Report
Located in
EGAF00008776407 cram 1.1 MB
EGAF00008776408 cram 856.0 MB
EGAF00008776409 cram 541.3 kB
EGAF00008776410 cram 389.0 kB
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EGAF00008776413 cram 482.2 kB
EGAF00008776414 cram 333.2 kB
EGAF00008776415 cram 314.6 kB
EGAF00008776416 cram 425.1 kB
EGAF00008776417 cram 391.5 kB
EGAF00008776418 cram 252.9 MB
EGAF00008776419 cram 1.9 MB
EGAF00008776420 cram 14.8 MB
EGAF00008776421 cram 309.4 MB
EGAF00008776422 cram 389.0 MB
EGAF00008776423 cram 328.6 MB
EGAF00008776424 cram 210.5 MB
EGAF00008776425 cram 369.3 kB
EGAF00008776426 cram 411.8 kB
EGAF00008776427 cram 387.7 kB
EGAF00008776428 cram 402.0 kB
EGAF00008776429 cram 409.8 kB
EGAF00008776430 cram 1.9 MB
EGAF00008776431 cram 391.2 kB
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EGAF00008776433 cram 128.5 kB
EGAF00008776434 cram 177.1 kB
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EGAF00008776436 cram 156.0 kB
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EGAF00008776484 cram 336.3 MB
EGAF00008776485 cram 144.2 kB
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EGAF00008776488 cram 105.5 kB
EGAF00008776489 cram 84.1 kB
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EGAF00008776494 cram 179.1 MB
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EGAF00008776497 cram 86.7 kB
EGAF00008776498 cram 87.5 kB
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EGAF00008776505 cram 244.1 MB
EGAF00008776506 cram 97.6 kB
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EGAF00008776508 cram 101.9 kB
EGAF00008776509 cram 1.0 MB
EGAF00008776510 cram 747.7 MB
EGAF00008776511 cram 665.3 MB
EGAF00008776512 cram 1.9 GB
EGAF00008776513 cram 751.2 MB
EGAF00008776514 cram 1.7 GB
EGAF00008776515 cram 125.2 MB
EGAF00008776516 cram 593.5 MB
EGAF00008776517 cram 281.6 MB
EGAF00008776518 cram 705.5 MB
EGAF00008776519 cram 70.2 MB
EGAF00008776520 cram 71.3 MB
EGAF00008776521 cram 741.4 MB
EGAF00008776522 cram 760.1 MB
EGAF00008776523 cram 1.4 MB
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EGAF00008776526 cram 102.1 MB
EGAF00008776527 cram 107.8 MB
EGAF00008776528 cram 258.9 MB
EGAF00008776529 cram 106.9 MB
EGAF00008776530 cram 94.1 MB
EGAF00008776531 cram 125.8 MB
EGAF00008776532 cram 120.2 MB
EGAF00008776533 cram 138.9 MB
EGAF00008776534 cram 105.1 MB
EGAF00008776535 cram 116.5 MB
EGAF00008776536 cram 738.9 kB
EGAF00008776537 cram 1.2 MB
EGAF00008776538 cram 1.8 MB
EGAF00008776539 cram 240.2 MB
EGAF00008776540 cram 2.6 MB
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EGAF00008776542 cram 1.3 MB
EGAF00008776543 cram 700.5 MB
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EGAF00008776545 cram 683.8 MB
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EGAF00008776550 cram 270.7 MB
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EGAF00008776555 cram 141.6 MB
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EGAF00008776557 cram 151.8 MB
EGAF00008776558 cram 143.1 MB
EGAF00008776559 cram 47.0 MB
EGAF00008776560 cram 325.8 MB
EGAF00008776561 cram 233.7 MB
EGAF00008776562 cram 176.9 MB
EGAF00008776563 cram 266.0 kB
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EGAF00008776565 cram 495.7 kB
EGAF00008776566 cram 642.0 kB
EGAF00008776567 cram 399.2 kB
EGAF00008776568 cram 371.8 kB
EGAF00008776569 cram 208.5 kB
EGAF00008776570 cram 447.0 kB
EGAF00008776571 cram 325.6 kB
EGAF00008776572 cram 959.1 MB
EGAF00008776573 cram 291.9 kB
EGAF00008776574 cram 308.2 kB
EGAF00008776575 cram 333.0 kB
EGAF00008776576 cram 72.9 MB
EGAF00008776577 cram 130.2 MB
EGAF00008776578 cram 151.1 MB
EGAF00008776579 cram 346.6 kB
EGAF00008776580 cram 129.2 MB
EGAF00008776581 cram 121.4 MB
EGAF00008776582 cram 136.3 MB
EGAF00008776583 cram 356.0 MB
EGAF00008776584 cram 125.0 MB
EGAF00008776585 cram 175.0 MB
EGAF00008776586 cram 133.0 MB
EGAF00008776587 cram 109.4 MB
EGAF00008776588 cram 114.8 MB
EGAF00008776589 cram 264.0 kB
EGAF00008776590 cram 350.5 kB
EGAF00008776591 cram 517.7 kB
EGAF00008776592 cram 690.4 kB
EGAF00008776593 cram 415.3 kB
EGAF00008776594 cram 660.6 MB
EGAF00008776595 cram 428.5 kB
EGAF00008776596 cram 255.8 kB
EGAF00008776597 cram 514.9 kB
EGAF00008776598 cram 345.7 kB
EGAF00008776599 cram 310.7 kB
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EGAF00008776601 cram 415.2 kB
EGAF00008776602 cram 116.8 MB
EGAF00008776603 cram 67.5 MB
EGAF00008776604 cram 101.4 MB
EGAF00008776605 cram 2.9 GB
EGAF00008776606 cram 165.4 MB
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EGAF00008776637 cram 120.3 MB
EGAF00008776638 cram 170.0 MB
EGAF00008776639 cram 739.7 kB
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EGAF00008776650 cram 2.1 MB
EGAF00008776651 cram 434.0 kB
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EGAF00008776656 cram 181.3 MB
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EGAF00008776664 cram 150.3 MB
EGAF00008776665 cram 352.7 kB
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EGAF00008776669 cram 621.1 kB
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EGAF00008776907 cram 946.2 kB
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EGAF00008778497 cram 297.9 MB
EGAF00008778498 cram 434.3 MB
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EGAF00008778507 cram 79.3 MB
EGAF00008778508 cram 4.3 MB
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EGAF00008779983 cram 418.9 kB
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3632 Files (423.9 GB)