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Dissecting_global_protective_immune_response_to_dengue_virus_at_a_single_cell_resolution

1) This data is part of a pre-publication release. For information on the proper use of pre-publication data shared by the Wellcome Trust Sanger Institute please see http://www.sanger.ac.uk/datasharing/

Type: Transcriptome Analysis
Archive: European Genome-phenome Archive (EGA)

2 Datasets 1 Publication

Click on a Dataset ID in the table below to learn more, and to find out who to contact about access to these data

Dataset ID	Description	Technology	Samples
EGAD00001015634	This dataset comprises single-cell RNA sequencing (scRNA-seq) and immune receptor (TCR/BCR) profiling of peripheral blood mononuclear cells (PBMCs) collected from individuals infected with dengue virus (DENV) exhibiting different clinical severities: asymptomatic dengue (AD), dengue fever (DF), and dengue hemorrhagic fever (DHF). PBMCs were collected during the acute phase and, in some cases, during convalescence. The data provide a resource for understanding protective versus pathogenic immune responses in dengue infection.	Illumina NovaSeq 6000	1
EGAD00001015637	This dataset contains single-cell RNA sequencing (Smart-seq2) and paired TCR repertoire data of sorted dengue virus (DENV)-specific CD8⁺ T cells from individuals with differing clinical outcomes: asymptomatic dengue (AD), dengue fever (DF), and dengue hemorrhagic fever (DHF). Samples were obtained from HLA-A11⁺ and HLA-A24⁺ individuals during acute and convalescent phases, with antigen-specific CD8⁺ T cells isolated using HLA tetramers loaded with immunodominant DENV epitopes. The study identifies phenotypically distinct T cell subsets associated with disease severity, TCR avidity, and antigen reactivity to current or prior DENV serotypes. The dataset supports the understanding of CD8⁺ T cell heterogeneity, TCR features, and potential mechanisms of CD8⁺ T cell-mediated protection versus immunopathogenesis in dengue infection.	Illumina HiSeq 4000	1

Publications	Citations
Heterogeneity and dynamics of DENV-specific CD8 + T cells in dengue infection. Srikor S, Sungnak W, Trakoolsoontorn C, Poonpanichakul T, Jiravejchakul N, Jevapatarakul D, Thungsatianpun N, Opasawatchai A, Dratva L, Kretschmer L, DENFREE Thailand, Matangkasombut O, Screaton G, Dejnirattisai W, Duangchinda T, Park J, Meyer K, Mongkolsapaya J, Charoensawan V, Teichmann SA, Matangkasombut P. Nat Commun 17: 2026 7103	0

Publications

Citations

Heterogeneity and dynamics of DENV-specific CD8 + T cells in dengue infection.
Srikor S, Sungnak W, Trakoolsoontorn C, Poonpanichakul T, Jiravejchakul N, Jevapatarakul D, Thungsatianpun N, Opasawatchai A, Dratva L, Kretschmer L, DENFREE Thailand, Matangkasombut O, Screaton G, Dejnirattisai W, Duangchinda T, Park J, Meyer K, Mongkolsapaya J, Charoensawan V, Teichmann SA, Matangkasombut P. Nat Commun 17: 2026 7103