EED inhibition of organoid development

Transcriptomics and epigenomics after chemical inhibition of EED during early human brain organoid development. To investigate the role of H3K27me3 inhibition during neuroectoderm induction, we treated brain organoids with 3 concentrations of EED inhibitor (and control) during the transition of pluripotency to neuroepithelium. At the neuroepithelium stage, we profiled the organoids using scRNA-seq (transcriptome) and bulk Cut&Tag (H3K27me3, H3K27ac). Library preparation for scRNA-seq was carried out with the 10x genomics platform.

25/06/2024
2 samples
DAC: EGAC50000000103
Technology: unspecified

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Studies are experimental investigations of a particular phenomenon, e.g., case-control studies on a particular trait or cancer research projects reporting matching cancer normal genomes from patients.

Study ID	Study Title	Study Type
EGAS50000000155	Epigenomic atlas of organoid development	Epigenetics

This table displays only public information pertaining to the files in the dataset. If you wish to access this dataset, please submit a request. If you already have access to these data files, please consult the download documentation.

ID	File Type	Size	Quality Report
EGAF50000064865	fastq.gz	677.6 MB	Report
EGAF50000064904	fastq.gz	444.4 MB	Report
EGAF50000064905	fastq.gz	470.0 MB	Report
EGAF50000064906	fastq.gz	361.2 MB	Report
EGAF50000065115	fastq.gz	305.4 MB	Report
EGAF50000065116	fastq.gz	324.7 MB	Report
EGAF50000065117	fastq.gz	371.7 MB	Report
EGAF50000065118	fastq.gz	750.6 MB	Report
EGAF50000065119	fastq.gz	1.9 GB	Report
EGAF50000065120	fastq.gz	2.1 GB	Report
EGAF50000065121	fastq.gz	7.5 GB	Report
EGAF50000065122	fastq.gz	288.6 MB	Report
EGAF50000065123	fastq.gz	584.7 MB	Report
EGAF50000065124	fastq.gz	290.6 MB	Report
EGAF50000065125	fastq.gz	592.6 MB	Report
EGAF50000065126	fastq.gz	214.7 MB	Report
EGAF50000065127	fastq.gz	432.2 MB	Report
EGAF50000065185	fastq.gz	676.3 MB	Report
EGAF50000065186	fastq.gz	627.1 MB	Report
EGAF50000065187	fastq.gz	975.7 MB	Report
EGAF50000065188	fastq.gz	411.8 MB	Report
EGAF50000065189	fastq.gz	409.8 MB	Report
EGAF50000065190	fastq.gz	244.9 MB	Report
EGAF50000065191	fastq.gz	258.1 MB	Report
EGAF50000065192	fastq.gz	393.9 MB	Report
EGAF50000065193	fastq.gz	424.9 MB	Report
EGAF50000065194	fastq.gz	388.8 MB	Report
EGAF50000065195	fastq.gz	416.2 MB	Report
EGAF50000065196	fastq.gz	337.8 MB	Report
EGAF50000065197	fastq.gz	353.9 MB	Report
EGAF50000065198	fastq.gz	383.0 MB	Report
EGAF50000065199	fastq.gz	1.1 GB	Report
EGAF50000065200	fastq.gz	346.0 MB	Report
EGAF50000065201	fastq.gz	908.4 MB	Report
EGAF50000065202	fastq.gz	1.9 GB	Report
EGAF50000065203	fastq.gz	1.3 GB	Report
EGAF50000065204	fastq.gz	4.3 GB	Report
EGAF50000065205	fastq.gz	10.0 GB	Report
EGAF50000065206	fastq.gz	529.3 MB	Report
EGAF50000065207	fastq.gz	276.4 MB	Report
EGAF50000065208	fastq.gz	281.3 MB	Report
EGAF50000065209	fastq.gz	289.1 MB	Report
EGAF50000065228	fastq.gz	293.2 MB	Report
EGAF50000065240	fastq.gz	10.1 GB	Report
EGAF50000065245	fastq.gz	18.1 GB	Report
EGAF50000065246	fastq.gz	876.8 MB	Report
EGAF50000065247	fastq.gz	1.8 GB	Report
EGAF50000065248	fastq.gz	1.3 GB	Report
EGAF50000065249	fastq.gz	4.3 GB	Report
EGAF50000065250	fastq.gz	1.2 GB	Report
EGAF50000065251	fastq.gz	4.2 GB	Report
EGAF50000065252	fastq.gz	9.9 GB	Report
EGAF50000065253	fastq.gz	300.7 MB	Report
EGAF50000065254	fastq.gz	637.4 MB	Report
EGAF50000065255	fastq.gz	603.3 MB	Report
EGAF50000065256	fastq.gz	380.3 MB	Report
EGAF50000065257	fastq.gz	216.4 MB	Report
EGAF50000065258	fastq.gz	438.2 MB	Report
EGAF50000065259	fastq.gz	1.9 GB	Report
EGAF50000065260	fastq.gz	7.5 GB	Report
EGAF50000065276	fastq.gz	1.2 GB	Report
EGAF50000065277	fastq.gz	4.2 GB	Report
EGAF50000065278	fastq.gz	9.8 GB	Report
EGAF50000065279	fastq.gz	422.3 MB	Report
EGAF50000065280	fastq.gz	18.3 GB	Report
EGAF50000065281	fastq.gz	2.1 GB	Report
EGAF50000065288	fastq.gz	285.2 MB	Report
67 Files (145.4 GB)