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EED inhibition of organoid development

Transcriptomics and epigenomics after chemical inhibition of EED during early human brain organoid development. To investigate the role of H3K27me3 inhibition during neuroectoderm induction, we treated brain organoids with 3 concentrations of EED inhibitor (and control) during the transition of pluripotency to neuroepithelium. At the neuroepithelium stage, we profiled the organoids using scRNA-seq (transcriptome) and bulk Cut&Tag (H3K27me3, H3K27ac). Library preparation for scRNA-seq was carried out with the 10x genomics platform.

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Studies are experimental investigations of a particular phenomenon, e.g., case-control studies on a particular trait or cancer research projects reporting matching cancer normal genomes from patients.

Study ID Study Title Study Type
EGAS50000000155 Epigenetics

This table displays only public information pertaining to the files in the dataset. If you wish to access this dataset, please submit a request. If you already have access to these data files, please consult the download documentation.

ID File Type Size Located in
EGAF50000064865 fastq.gz 677.6 MB
EGAF50000064904 fastq.gz 444.4 MB
EGAF50000064905 fastq.gz 470.0 MB
EGAF50000064906 fastq.gz 361.2 MB
EGAF50000065115 fastq.gz 305.4 MB
EGAF50000065116 fastq.gz 324.7 MB
EGAF50000065117 fastq.gz 371.7 MB
EGAF50000065118 fastq.gz 750.6 MB
EGAF50000065119 fastq.gz 1.9 GB
EGAF50000065120 fastq.gz 2.1 GB
EGAF50000065121 fastq.gz 7.5 GB
EGAF50000065122 fastq.gz 288.6 MB
EGAF50000065123 fastq.gz 584.7 MB
EGAF50000065124 fastq.gz 290.6 MB
EGAF50000065125 fastq.gz 592.6 MB
EGAF50000065126 fastq.gz 214.7 MB
EGAF50000065127 fastq.gz 432.2 MB
EGAF50000065185 fastq.gz 676.3 MB
EGAF50000065186 fastq.gz 627.1 MB
EGAF50000065187 fastq.gz 975.7 MB
EGAF50000065188 fastq.gz 411.8 MB
EGAF50000065189 fastq.gz 409.8 MB
EGAF50000065190 fastq.gz 244.9 MB
EGAF50000065191 fastq.gz 258.1 MB
EGAF50000065192 fastq.gz 393.9 MB
EGAF50000065193 fastq.gz 424.9 MB
EGAF50000065194 fastq.gz 388.8 MB
EGAF50000065195 fastq.gz 416.2 MB
EGAF50000065196 fastq.gz 337.8 MB
EGAF50000065197 fastq.gz 353.9 MB
EGAF50000065198 fastq.gz 383.0 MB
EGAF50000065199 fastq.gz 1.1 GB
EGAF50000065200 fastq.gz 346.0 MB
EGAF50000065201 fastq.gz 908.4 MB
EGAF50000065202 fastq.gz 1.9 GB
EGAF50000065203 fastq.gz 1.3 GB
EGAF50000065204 fastq.gz 4.3 GB
EGAF50000065205 fastq.gz 10.0 GB
EGAF50000065206 fastq.gz 529.3 MB
EGAF50000065207 fastq.gz 276.4 MB
EGAF50000065208 fastq.gz 281.3 MB
EGAF50000065209 fastq.gz 289.1 MB
EGAF50000065228 fastq.gz 293.2 MB
EGAF50000065240 fastq.gz 10.1 GB
EGAF50000065245 fastq.gz 18.1 GB
EGAF50000065246 fastq.gz 876.8 MB
EGAF50000065247 fastq.gz 1.8 GB
EGAF50000065248 fastq.gz 1.3 GB
EGAF50000065249 fastq.gz 4.3 GB
EGAF50000065250 fastq.gz 1.2 GB
EGAF50000065251 fastq.gz 4.2 GB
EGAF50000065252 fastq.gz 9.9 GB
EGAF50000065253 fastq.gz 300.7 MB
EGAF50000065254 fastq.gz 637.4 MB
EGAF50000065255 fastq.gz 603.3 MB
EGAF50000065256 fastq.gz 380.3 MB
EGAF50000065257 fastq.gz 216.4 MB
EGAF50000065258 fastq.gz 438.2 MB
EGAF50000065259 fastq.gz 1.9 GB
EGAF50000065260 fastq.gz 7.5 GB
EGAF50000065276 fastq.gz 1.2 GB
EGAF50000065277 fastq.gz 4.2 GB
EGAF50000065278 fastq.gz 9.8 GB
EGAF50000065279 fastq.gz 422.3 MB
EGAF50000065280 fastq.gz 18.3 GB
EGAF50000065281 fastq.gz 2.1 GB
EGAF50000065288 fastq.gz 285.2 MB
67 Files (145.4 GB)