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snRNA-seq dataset and atlas from subcortical white matter MS lesions (CA & CI) and controls

Dataset including FASTQ files for all snRNA-seq samples from subcortical Multiple Sclerosis (MS) lesions and controls (n=15), together with the curated and annotated snRNA-seq atlas.

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DAC SubcorticalMS_ST_snRNAseq Data Access Policy

DATA ACCESS AGREEMENT These terms and conditions govern access to the managed access datasets (details of which are set out in Appendix I) to which the User Institution has requested access. The User Institution agrees to be bound by these terms and conditions. Definitions Authorized Personnel: The individuals at the User Institution to whom the DAC SubcorticalMS_ST_snRNAseq grants access to the Data. This includes the User, the individuals listed in Appendix II and any other individuals for whom the User Institution subsequently requests access to the Data. Details of the initial Authorized Personnel are set out in Appendix II. Data: The managed access datasets to which the User Institution has requested access. Data Producers: The DAC SubcorticalMS_ST_snRNAseq and the collaborators listed in Appendix I responsible for the development, organisation, and oversight of these Data. External Collaborator: A collaborator of the User, working for an institution other than the User Institution. Project: The project for which the User Institution has requested access to these Data. A description of the Project is set out in Appendix II. Publications: Includes, without limitation, articles published in print journals, electronic journals, reviews, books, posters and other written and verbal presentations of research. Research Participant: An individual whose data form part of these Data. Research Purposes: Shall mean research that is seeking to advance the understanding of genetics and genomics, including the treatment of disorders, and work on statistical methods that may be applied to such research. User: The principal investigator for the Project. User Institution(s): The Institution that has requested access to the Data. DAC SubcorticalMS_ST_snRNAseq: Data Access Committee, Laboratory of Lucas Schirmer, Medical Faculty Mannheim, Heidelberg University, Germany 1. The User Institution agrees to only use these Data for the purpose of the Project (described in Appendix II) and only for Research Purposes. The User Institution further agrees that it will only use these Data for Research Purposes which are within the limitations (if any) set out in Appendix I. 2. The User Institution agrees to preserve, at all times, the confidentiality of these Data. In particular, it undertakes not to use, or attempt to use these Data to compromise or otherwise infringe the confidentiality of information on Research Participants. Without prejudice to the generality of the foregoing, the User Institution agrees to use at least the measures set out in Appendix I to protect these Data. 3. The User Institution agrees to protect the confidentiality of Research Participants in any research papers or publications that they prepare by taking all reasonable care to limit the possibility of identification. 4. The User Institution agrees not to link or combine these Data to other information or archived data available in a way that could re-identify the Research Participants, even if access to that data has been formally granted to the User Institution or is freely available without restriction. 5. The User Institution agrees only to transfer or disclose these Data, in whole or part, or any material derived from these Data, to the Authorized Personnel. Should the User Institution wish to share these Data with an External Collaborator, the External Collaborator must complete a separate application for access to these Data. 6. The User Institution agrees that the Data Producers, and all other parties involved in the creation, funding or protection of these Data: a) make no warranty or representation, express or implied as to the accuracy, quality or comprehensiveness of these Data; b) exclude to the fullest extent permitted by law all liability for actions, claims, proceedings, demands, losses (including but not limited to loss of profit), costs, awards damages and payments made by the Recipient that may arise (whether directly or indirectly) in any way whatsoever from the Recipient’s use of these Data or from the unavailability of, or break in access to, these Data for whatever reason and; c) bear no responsibility for the further analysis or interpretation of these Data. 7. The User Institution agrees to follow the Fort Lauderdale Guidelines (http://www.wellcome.ac.uk/stellent/groups/corporatesite/@policy_communications/documents/web_document/wtd003207.pdf ) and the Toronto Statement (http://www.nature.com/nature/journal/v461/n7261/full/461168a.html). This includes but is not limited to recognizing the contribution of the Data Producers and including a proper acknowledgement in all reports or publications resulting from the use of these Data. 8. The User Institution agrees to follow the Publication Policy in Appendix III. This includes respecting the moratorium period for the Data Producers to publish the first peer-reviewed report describing and analysing these Data. 9. The User Institution agrees not to make intellectual property claims on these Data and not to use intellectual property protection in ways that would prevent or block access to, or use of, any element of these Data, or conclusion drawn directly from these Data. 10. The User Institution can elect to perform further research that would add intellectual and resource capital to these data and decide to obtain intellectual property rights on these downstream discoveries. In this case, the User Institution agrees to implement licensing policies that will not obstruct further research and to follow the U.S. National Institutes of Health Best Practices for the Licensing of Genomic Inventions (2005) (https://www.icgc.org/files/daco/NIH_BestPracticesLicensingGenomicInventions_2005_en.pdf ) in conformity with the Organisation for Economic Co-operation and Development Guidelines for the Licensing of the Genetic Inventions (2006) (http://www.oecd.org/science/biotech/36198812.pdf ). 11. The User Institution agrees to destroy/discard the Data held, once it is no longer used for the Project, unless obliged to retain the data for archival purposes in conformity with audit or legal requirements. 12. The User Institution will notify the DAC SubcorticalMS_ST_snRNAseq within 30 days of any changes or departures of Authorized Personnel. 13. The User Institution will notify the DAC SubcorticalMS_ST_snRNAseq prior to any significant changes to the protocol for the Project. 14. The User Institution will notify the DAC SubcorticalMS_ST_snRNAseq as soon as it becomes aware of a breach of the terms or conditions of this agreement. 15. The DAC SubcorticalMS_ST_snRNAseq may terminate this agreement by written notice to the User Institution. If this agreement terminates for any reason, the User Institution will be required to destroy any Data held, including copies and backup copies. This clause does not prevent the User Institution from retaining these data for archival purpose in conformity with audit or legal requirements. 16. The User Institution accepts that it may be necessary for the Data Producers to alter the terms of this agreement from time to time. As an example, this may include specific provisions relating to the Data required by Data Producers other than the DAC SubcorticalMS_ST_snRNAseq. In the event that changes are required, the Data Producers or their appointed agent will contact the User Institution to inform it of the changes and the User Institution may elect to accept the changes or terminate the agreement. 17. If requested, the User Institution will allow data security and management documentation to be inspected to verify that it is complying with the terms of this agreement. 18. The User Institution agrees to distribute a copy of these terms to the Authorized Personnel. The User Institution will procure that the Authorized Personnel comply with the terms of this agreement.

Studies are experimental investigations of a particular phenomenon, e.g., case-control studies on a particular trait or cancer research projects reporting matching cancer normal genomes from patients.

Study ID Study Title Study Type
EGAS50000000354 RNASeq
  • Changed title
  • Added information
  • Dataset Released

This table displays only public information pertaining to the files in the dataset. If you wish to access this dataset, please submit a request. If you already have access to these data files, please consult the download documentation.

ID File Type Size Located in
EGAF50000110503 fastq.gz 3.4 GB
EGAF50000110504 fastq.gz 32.8 GB
EGAF50000110505 fastq.gz 20.1 GB
EGAF50000110506 fastq.gz 2.1 GB
EGAF50000110507 fastq.gz 18.1 GB
EGAF50000110508 fastq.gz 2.1 GB
EGAF50000110509 fastq.gz 23.3 GB
EGAF50000110510 fastq.gz 38.4 GB
EGAF50000110511 fastq.gz 3.3 GB
EGAF50000110512 fastq.gz 46.2 GB
EGAF50000110517 fastq.gz 2.8 GB
EGAF50000110518 fastq.gz 2.8 GB
EGAF50000110519 fastq.gz 24.4 GB
EGAF50000110520 fastq.gz 30.8 GB
EGAF50000110521 fastq.gz 21.7 GB
EGAF50000110522 fastq.gz 27.4 GB
EGAF50000110523 fastq.gz 2.0 GB
EGAF50000110524 fastq.gz 19.4 GB
EGAF50000110525 fastq.gz 13.0 GB
EGAF50000110526 fastq.gz 1.8 GB
EGAF50000110527 fastq.gz 2.0 GB
EGAF50000110528 fastq.gz 1.2 GB
EGAF50000110529 fastq.gz 1.4 GB
EGAF50000110530 fastq.gz 12.7 GB
EGAF50000110531 fastq.gz 9.8 GB
EGAF50000110532 fastq.gz 3.0 GB
EGAF50000110533 fastq.gz 2.5 GB
EGAF50000110534 fastq.gz 23.6 GB
EGAF50000110535 fastq.gz 30.1 GB
EGAF50000110536 fastq.gz 2.7 GB
EGAF50000110537 fastq.gz 3.1 GB
EGAF50000110538 fastq.gz 31.6 GB
EGAF50000110539 fastq.gz 25.7 GB
EGAF50000110540 fastq.gz 1.7 GB
EGAF50000110541 fastq.gz 22.8 GB
EGAF50000110542 fastq.gz 17.9 GB
EGAF50000110543 fastq.gz 2.5 GB
EGAF50000110544 fastq.gz 32.6 GB
EGAF50000110545 fastq.gz 26.4 GB
EGAF50000110546 fastq.gz 2.7 GB
EGAF50000110547 fastq.gz 24.7 GB
EGAF50000110548 fastq.gz 18.8 GB
EGAF50000110549 fastq.gz 25.1 GB
EGAF50000110550 fastq.gz 20.9 GB
EGAF50000110551 fastq.gz 2.6 GB
EGAF50000110552 fastq.gz 2.1 GB
EGAF50000110553 fastq.gz 29.8 GB
EGAF50000110554 fastq.gz 24.4 GB
EGAF50000110555 fastq.gz 2.1 GB
EGAF50000110556 fastq.gz 29.2 GB
EGAF50000110557 fastq.gz 23.7 GB
EGAF50000110558 fastq.gz 1.3 GB
EGAF50000110559 fastq.gz 17.2 GB
EGAF50000110560 fastq.gz 13.9 GB
EGAF50000110587 h5ad 1.8 GB
55 Files (829.5 GB)