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snRNA-seq on patient tumours

snRNA-seq performed on patient tumours (n = 6 patients, one biopsy sample each sequenced) using the 10x technology. Single nuclei were acquired from six frozen mCRPC biopsies (4 lymph node, 2 liver metastases) obtained from consenting patients treated at the Royal Marsden Hospital between 2018 and 2023 under an institutional review board approved research protocol (Research Ethics Committee approval number: 04/Q0801/60). All six patients had previously received androgen-receptor signalling inhibitor(s) and five of six patients had previously received taxane(s).

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Patient snRNA-seq Data Sharing Policy

Cancer Biomarkers team at The Institute of Cancer Research Dataset Publishing Policy 1. Purpose The purpose of this policy is to establish guidelines for the public use of datasets generated by The Institute of Cancer Research (ICR). This policy aims to enhance transparency and support further research through access to high-quality data. 2. Scope This policy applies to all datasets produced, collected, or managed by ICR that are intended for public release. 3. Data Privacy and Confidentiality ICR is committed to protecting the privacy of individuals whose data is included in its datasets. All datasets will be reviewed and anonymized as necessary to ensure that no personally identifiable information (PII) is released. Data that cannot be sufficiently anonymized will not be made publicly available. 4. Legal and Ethical Considerations All datasets will be published in compliance with applicable laws and regulations, including data protection laws and intellectual property rights. ICR ensures that all data releases are ethically sound and do not infringe on the rights of individuals or third parties. 5. Data Quality and Accuracy The Cancer Biomarkers Team at ICR is dedicated to providing high-quality data. All datasets will undergo rigorous quality checks to ensure accuracy, completeness, and reliability prior to publication. However, ICR does not guarantee the absolute accuracy of the information provided. 6. Data Documentation and Metadata Each dataset will be accompanied by comprehensive metadata, including information on data sources, collection methods, and instruments. This documentation will help users understand and accurately interpret the data. 7. Terms of Use Users are free to access and use the data provided that ICR is credited as the source in any public presentation of the data and any findings based on it. The data may not be used for commercial purposes. 8. Liability Disclaimer The Cancer Biomarkers team a the ICR disclaims any liability for errors or omissions in the datasets or for any loss or damage incurred as a result of their use. Users are responsible for verifying the accuracy and suitability of the data for their intended purposes. 9. Data Access and Distribution Datasets will be available through the European Genome-Phenome Archive (EGA). 10. Contact Information For questions or concerns regarding this policy or the use of datasets, please contact the ICR Data Governance Team at information.governance@icr.ac.uk.

Studies are experimental investigations of a particular phenomenon, e.g., case-control studies on a particular trait or cancer research projects reporting matching cancer normal genomes from patients.

Study ID Study Title Study Type
EGAS50000000617 Transcriptome Sequencing

This table displays only public information pertaining to the files in the dataset. If you wish to access this dataset, please submit a request. If you already have access to these data files, please consult the download documentation.

ID File Type Size Located in
EGAF50000200703 fastq.gz 24.6 GB
EGAF50000200704 fastq.gz 18.2 GB
EGAF50000200705 fastq.gz 23.2 GB
EGAF50000200706 fastq.gz 18.0 GB
EGAF50000200707 fastq.gz 29.8 GB
EGAF50000200708 fastq.gz 22.3 GB
EGAF50000200709 fastq.gz 25.7 GB
EGAF50000200710 fastq.gz 19.5 GB
EGAF50000200711 fastq.gz 25.3 GB
EGAF50000200712 fastq.gz 19.0 GB
EGAF50000200713 fastq.gz 29.0 GB
EGAF50000200714 fastq.gz 22.0 GB
12 Files (276.5 GB)