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Single-cell RNA-sequencing data of human iPSC-derived (hiPSC-derived) astrocytes, both alone and in co-culture with neurons, to define the molecular response of astrocytes to misfolded alpha-synuclein.

Samples were derived from an human iPSC-derived astrocyte line, both alone and in co-culture with neurons +/- alpha-synuclein oligomer treatment.

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Francis Crick - Data Access Agreement - General Anon

[Note: This agreement is provided as an example of the terms we ask data users to adhere to. The final agreement we issue may vary from the terms specified below.] [Section 2] These terms and conditions govern access to the managed access datasets (set out in Section 3) to which the Data Recipient has requested access. The Data Recipient agrees to be bound by these terms and conditions. Definitions Authorised Personnel: The individuals at the Data Recipient to whom the Crick grants access to the Data, all of whom shall be employees of the Data Recipient or registered students at the Data Recipient. This includes the User, the initial individuals listed in Section 1 and any other individuals for whom the Data Recipient subsequently requests access to the Data. Crick: The Francis Crick Institute Limited, a registered charity in England and Wales (no. 1140062) and a company registered in England and Wales (no. 06885462), whose address is at 1 Midland Road, London, NW1 1AT, and who is making the Data available. Data: The managed access datasets to which the Data Recipient has requested access. Data Producers: The Crick and any collaborators listed in Section 3 responsible for the development, organisation, and oversight of these Data. External Collaborator: A collaborator of the Data Recipient, working for an institution other than the Data Recipient. Principal Investigator: The principal investigator for the Project as set out in Section 1. Project: The project for which the Data Recipient has requested access to these Data. A description of the Project is set out in Section 1. Publications: Includes, without limitation, articles published in print journals, electronic journals, reviews, books, posters and other written and verbal presentations of research. Research Participant: An individual whose data form part of these Data. Research Purposes: research that is seeking to advance the understanding of genetics and genomics, including the treatment of disorders, and work on statistical methods that may be applied to such research. Data Recipient(s): The institution that has requested access to the Data, as set out in Section 1. 1. The Data Recipient agrees to only use these Data: a) for the purpose and duration of the Project (described in Section 1); b) for Research Purposes; c) at the address in Section 1; d) in accordance with all applicable laws, regulations and ethical requirements, including without limitation applicable laws on data protection; and e) for Research Purposes which are within the limitations (if any) set out in Section 3. Any use of the Data for another research field or area will need to be approved under a new agreement. 2. The Data Recipient agrees to preserve, at all times, the confidentiality of these Data. It undertakes not to use, or attempt to use these Data to compromise or otherwise infringe the confidentiality of information on Research Participants. The Data Recipient agrees to use at least the measures set out in Section 3 to protect these Data. 3. The Data Recipient agrees to protect the confidentiality of Research Participants in any research papers or publications that they prepare by taking all reasonable care to limit the possibility of identification. 4. The Data Recipient agrees not to link or combine these Data to other information or archived data available, or analyse or make any use of any Data in a way that could, or has the potential to, re-identify the Research Participants, even if access to that data has been formally granted to the Data Recipient or is freely available without restriction. 5. The Data Recipient agrees only to transfer or disclose these Data, in whole or part, or any material derived from these Data, to the Authorised Personnel. If the employment/ affiliation of any Authorised Personnel with the Data Recipient ends, or the Authorised Personnel’s professional responsibilities no longer require access to the Data, or the scope of required access changes, the Data Recipient shall ensure that such Authorised Personnel Data access is revoked or changed appropriately. If such access is not changed in a timely manner, the Data Recipient shall notify the Crick immediately. 6. The Data Recipient agrees to distribute a copy of these terms to the Authorised Personnel. The Data Recipient will procure that the Authorised Personnel comply with the terms of this agreement and will remain fully responsible for the Authorised Personnel’s non-compliance with this Agreement and/or applicable laws. Authorised Personnel must work under the direct supervision of the Principal Investigator of the Data Recipient (as set out in Section 1). 7. Should the Data Recipient wish to share these Data with an External Collaborator, the External Collaborator must complete and send to the Crick a separate application for access to these Data. 8. The Data Recipient agrees that the Data Producers, and all other parties involved in the creation, funding or protection of these Data: a) make no warranty or representation, express or implied as to the accuracy, quality or comprehensiveness of these Data; b) exclude to the fullest extent permitted by law all liability for actions, claims, proceedings, demands, losses (including but not limited to loss of profit, indirect, consequential, or incidental damages or losses arising from use of the Data), costs, awards damages and payments made by the Data Recipient that may arise (whether directly or indirectly) in any way whatsoever from the Data Recipient’s use of these Data or from the unavailability of, or break in access to, these Data for whatever reason and; c) bear no responsibility for the further analysis or interpretation of these Data. 9. The Data Recipient agrees to follow the Publication Policy in Section 4. This includes respecting the moratorium period for the Data Producers to publish the first peer-reviewed report describing and analysing these Data. 10. Nothing in this Agreement shall operate to transfer to the Data Recipient any intellectual property rights to the Data. The Data Recipient agrees not to make intellectual property claims on these Data and not to use intellectual property protection in ways that would prevent or block access to, or use of, any element of these Data, or conclusion drawn directly from these Data. 11. The Data Recipient can elect to perform further research that would add intellectual and resource capital to these data and decide to obtain intellectual property rights on these downstream discoveries. In this case, the Data Recipient agrees to implement licensing policies that will not obstruct further research and to follow the applicable laws of the Data Producer. 12. The Data Recipient agrees to destroy/discard the Data held, once it is no longer used for the Project, and at the latest 2 years after it is first accessed. 13. The Data Recipient will notify the Crick within 30 days of any changes or departures of Authorised Personnel. 14. The Data Recipient will notify the Crick prior to any significant changes to the protocol for the Project. 15. The Data Recipient will notify the Crick as soon as it becomes aware of a breach of the terms or conditions of this agreement. 16. The Crick may terminate this agreement by written notice to the Data Recipient. If this agreement terminates for any reason, the Data Recipient will be required to destroy any Data held, including copies and backup copies. This clause does not prevent the Data Recipient from retaining these data for archival purpose in conformity with audit or legal requirements. 17. The Data Recipient accepts that it may be necessary for the Data Producers to alter the terms of this agreement from time to time. As an example, this may include specific provisions relating to the Data required by Data Producers other than the Crick. In the event that changes are required, the Data Producers or their appointed agent will contact the Data Recipient to inform it of the changes and the Data Recipient may elect to accept the changes or terminate the agreement. 18. If requested, the Data Recipient will allow data security and management documentation to be inspected to verify that it is complying with the terms of this agreement. 19. This agreement (and any dispute, controversy, proceedings or claim of whatever nature arising out of this agreement or its formation) shall be construed, interpreted and governed by the laws of England and Wales and shall be subject to the exclusive jurisdiction of the English courts. Section 3 File access: Data can be held in unencrypted files on an institutional computer system, with Unix user group read/write access for one or more appropriate groups but not Unix world read/write access behind a secure firewall. Laptops holding these data should have password protected logins and screenlocks (set to lock after 5 min of inactivity). If held on USB keys or other portable hard drives, the data must be encrypted. The Data Recipient shall store the Data only in the original encrypted form from EGA. The Data Recipient agrees and warrants that Data shall only be decrypted when necessary and only during the performance of the Project. At the end of the Project, the Data Recipient shall delete any decrypted files, including additional copies, any computer records or files containing Data that have been created by the Data Recipient’s automatic archiving and back-up procedures. The Data Recipient agrees and warrants that Data shall not be accessed: a) outside the Data Recipient’s network, including non-Data Recipient email systems; b) using unauthorized devices, including personal devices; c) via mobile and wireless devices, and devices on networks with wireless access points. Data shall not be stored on any portable device (laptop, smartphone, etc.) unless absolutely necessary and always strongly encrypted, and the portable devices shall always have password protected logins and screen locks, set to lock after maximum five (5) minutes of inactivity. Data written to removable storage media shall be automatically encrypted without the Data Recipient intervention. Section 4 – PUBLICATION POLICY 1. The Data Producers intend to publish the results of their analysis of this dataset and do not consider its deposition into public databases to be the equivalent of such publications. The Data Producers anticipate that the dataset could be useful to other qualified researchers for a variety of purposes. However, some areas of work are subject to a publication moratorium. 2. The publication moratorium covers any Publications (including oral communications) that describe the use of the dataset and the Data Producers retain the right of first publication of its Data (or any part of the Data). The Data Recipient shall delay any Publication until the earlier of: (i) the Data Producers’ primary publication and (ii) twelve (12) months from the time the Data were deposited, unless the Data Producers have provided written consent to earlier submission for publication. The Data Recipient acknowledges that prompt publication or public disclosure of the results of the Research Project is encouraged and agrees that by publishing its global analyses of the Data, it will not disclose any results generated from the Data. 3. The Data Recipient may only publish Data if: (a) the Publication comprises only parts of the Data and not all of the Data; (b) it is not possible to establish the identity of any Research Participant from, or using, the Data contained in the publication; and (c) the publication complies with paragraph 4. 4. The Data Recipient shall ensure that each work based in whole or part on the Data that is authored by an Authorised Personnel acknowledges the published paper from which the Data derives, the version of the Data, and the role of the Crick source project and its funders in its distribution in accordance with customary scientific and academic practice. Further, the Data Recipient shall ensure that any Publication which contains, in any way, any patentable intellectual property shall be submitted to the Crick for review at least sixty (60) days prior to the intended publication. The Crick shall have thirty (30) days following receipt of the proposed Publication to review such publication and determine, if in the Crick’s reasonable opinion, a delay of the publication is necessary in order to protect its intellectual property (such delay not to exceed a period of six (6) months from the date of the Crick’s notice to the Data Recipient pursuant to this clause). 5. Further, within any permitted Publication including these Data the contribution of the Crick and the Data Producers shall be acknowledged in a manner consistent with the usual conventions in the field of research involved. 6. In any publications based on these Data, please describe how the data can be accessed, including the name of the hosting database (e.g., The European Genome-phenome Archive at the European Bioinformatics Institute) and its accession numbers (e.g., EGAS00000000029), and acknowledge its use in a form agreed by the Data Recipient with the Crick.

Studies are experimental investigations of a particular phenomenon, e.g., case-control studies on a particular trait or cancer research projects reporting matching cancer normal genomes from patients.

Study ID Study Title Study Type
EGAS50000000751 RNASeq

This table displays only public information pertaining to the files in the dataset. If you wish to access this dataset, please submit a request. If you already have access to these data files, please consult the download documentation.

ID File Type Size Located in
EGAF00008557489 fastq.gz 197.0 MB
EGAF00008557491 fastq.gz 255.8 MB
EGAF00008557492 fastq.gz 190.0 MB
EGAF00008557494 fastq.gz 247.0 MB
EGAF00008557495 fastq.gz 189.3 MB
EGAF00008557496 fastq.gz 246.6 MB
EGAF00008557498 fastq.gz 63.2 MB
EGAF00008557500 fastq.gz 228.5 MB
EGAF00008557501 fastq.gz 65.7 MB
EGAF00008557503 fastq.gz 237.3 MB
EGAF00008557504 fastq.gz 63.1 MB
EGAF00008557506 fastq.gz 226.9 MB
EGAF00008557507 fastq.gz 65.4 MB
EGAF00008557509 fastq.gz 235.1 MB
EGAF00008557510 fastq.gz 63.3 MB
EGAF00008557512 fastq.gz 225.7 MB
EGAF00008557513 fastq.gz 64.5 MB
EGAF00008557515 fastq.gz 229.9 MB
EGAF00008557516 fastq.gz 61.8 MB
EGAF00008557518 fastq.gz 221.8 MB
EGAF00008557519 fastq.gz 62.3 MB
EGAF00008557520 fastq.gz 224.7 MB
EGAF00008557525 fastq.gz 1.5 GB
EGAF00008557527 fastq.gz 469.7 MB
EGAF00008557529 fastq.gz 1.9 GB
EGAF00008557530 fastq.gz 488.6 MB
EGAF00008557532 fastq.gz 1.4 GB
EGAF00008557534 fastq.gz 468.7 MB
EGAF00008557535 fastq.gz 1.8 GB
EGAF00008557537 fastq.gz 486.2 MB
EGAF00008557538 fastq.gz 1.7 GB
EGAF00008557541 fastq.gz 1.8 GB
EGAF00008557543 fastq.gz 479.8 MB
EGAF00008557544 fastq.gz 1.7 GB
EGAF00008557546 fastq.gz 460.6 MB
EGAF00008557547 fastq.gz 1.7 GB
EGAF00008557550 fastq.gz 135.7 MB
EGAF00008557551 fastq.gz 1.7 GB
EGAF00008557553 fastq.gz 463.2 MB
EGAF00008557554 fastq.gz 130.8 MB
EGAF00008557555 fastq.gz 130.3 MB
EGAF00008557556 fastq.gz 1.6 GB
EGAF00008557557 fastq.gz 474.7 MB
EGAF00008557559 fastq.gz 135.0 MB
EGAF00008557560 fastq.gz 454.0 MB
EGAF00008557561 fastq.gz 1.7 GB
EGAF00008557563 fastq.gz 457.9 MB
EGAF00008557564 fastq.gz 131.1 MB
EGAF00008557565 fastq.gz 469.1 MB
EGAF00008557567 fastq.gz 133.3 MB
EGAF00008557568 fastq.gz 451.6 MB
EGAF00008557570 fastq.gz 128.0 MB
EGAF00008557571 fastq.gz 459.8 MB
EGAF00008557573 fastq.gz 129.0 MB
EGAF00008557574 fastq.gz 444.4 MB
EGAF00008557576 fastq.gz 450.7 MB
EGAF00008557578 fastq.gz 408.9 MB
EGAF00008557579 fastq.gz 506.6 MB
EGAF00008557581 fastq.gz 394.1 MB
EGAF00008557582 fastq.gz 488.8 MB
EGAF00008557584 fastq.gz 390.9 MB
EGAF00008557585 fastq.gz 45.0 MB
EGAF00008557586 fastq.gz 58.1 MB
EGAF00008557587 fastq.gz 486.3 MB
EGAF00008557589 fastq.gz 43.1 MB
EGAF00008557590 fastq.gz 55.8 MB
EGAF00008557592 fastq.gz 42.9 MB
EGAF00008557593 fastq.gz 55.6 MB
EGAF00008557595 fastq.gz 14.4 MB
EGAF00008557596 fastq.gz 51.9 MB
EGAF00008557598 fastq.gz 14.9 MB
EGAF00008557599 fastq.gz 53.8 MB
EGAF00008557601 fastq.gz 14.3 MB
EGAF00008557602 fastq.gz 51.5 MB
EGAF00008557604 fastq.gz 14.9 MB
EGAF00008557605 fastq.gz 53.3 MB
EGAF00008557607 fastq.gz 14.4 MB
EGAF00008557608 fastq.gz 51.3 MB
EGAF00008557610 fastq.gz 14.7 MB
EGAF00008557611 fastq.gz 52.3 MB
EGAF00008557613 fastq.gz 14.1 MB
EGAF00008557614 fastq.gz 50.4 MB
EGAF00008557616 fastq.gz 14.2 MB
EGAF00008557617 fastq.gz 51.1 MB
EGAF00008557619 fastq.gz 55.8 MB
EGAF00008557621 fastq.gz 58.0 MB
EGAF00008557622 fastq.gz 208.1 MB
EGAF00008557624 fastq.gz 55.7 MB
EGAF00008557626 fastq.gz 199.0 MB
EGAF00008557627 fastq.gz 57.8 MB
EGAF00008557629 fastq.gz 206.0 MB
EGAF00008557630 fastq.gz 56.0 MB
EGAF00008557631 fastq.gz 198.0 MB
EGAF00008557633 fastq.gz 57.1 MB
EGAF00008557635 fastq.gz 202.0 MB
EGAF00008557636 fastq.gz 54.8 MB
EGAF00008557638 fastq.gz 195.1 MB
EGAF00008557639 fastq.gz 55.2 MB
EGAF00008557641 fastq.gz 197.7 MB
EGAF00008557642 fastq.gz 173.6 MB
EGAF00008557644 fastq.gz 221.7 MB
EGAF00008557645 fastq.gz 166.5 MB
EGAF00008557647 fastq.gz 212.9 MB
EGAF00008557648 fastq.gz 165.9 MB
EGAF00008557650 fastq.gz 212.6 MB
EGAF00008557651 fastq.gz 99.4 MB
EGAF00008557653 fastq.gz 349.4 MB
EGAF00008557654 fastq.gz 103.4 MB
EGAF00008557656 fastq.gz 363.1 MB
EGAF00008557657 fastq.gz 99.2 MB
EGAF00008557659 fastq.gz 347.1 MB
EGAF00008557660 fastq.gz 103.1 MB
EGAF00008557662 fastq.gz 359.4 MB
EGAF00008557663 fastq.gz 99.7 MB
EGAF00008557665 fastq.gz 344.9 MB
EGAF00008557666 fastq.gz 101.5 MB
EGAF00008557668 fastq.gz 351.6 MB
EGAF00008557669 fastq.gz 97.3 MB
EGAF00008557671 fastq.gz 339.1 MB
EGAF00008557672 fastq.gz 98.0 MB
EGAF00008557674 fastq.gz 343.2 MB
EGAF00008557676 fastq.gz 314.0 MB
EGAF00008557677 fastq.gz 390.4 MB
EGAF00008557678 fastq.gz 301.5 MB
EGAF00008557680 fastq.gz 375.3 MB
EGAF00008557681 fastq.gz 300.3 MB
EGAF00008557682 fastq.gz 374.9 MB
EGAF00008617781 fastq.gz 200.4 MB
EGAF00008632376 fastq.gz 1.7 GB
EGAF00008632377 fastq.gz 1.8 GB
130 Files (46.1 GB)