PASCAL-MID Targeted amplicon sequencing of CD34+ HSPCs (CGD)
High-throughput amplicon sequencing were performed on CD34+ hematopoietic stem and progenitor cells (HSPCs) derived from 4 healthy donors and one unaffected heterozygous carrier of a CYBB c.252G>A variant causing X-linked granulomatous disease. Targeted genome editing were performed in the HSPCs of CYBA and CYBB genes using CRISPR-Cas9 and recombinant AAV6. To assess gene editing outcomes in CD34+ HSPCs, the targeted loci were amplified from genomic DNA and sequenced on an Illumina iSeq100.
- 29/07/2025
- 127 samples
- DAC: EGAC50000000680
- Technology: Illumina iSeq 100
Data Access Policy for data controlled by the PASCAL-MID DAC
Access to sequencing data controlled by the PASCAL-MID research center is granted according to Danish National ethics regulation and will comply with Danish law and the General Data Protection Regulation (GDPR). Due to Danish law, for the authors to be allowed to share the data (pseudonymized) it will require prior approval from The Danish National Committee on Health Research Ethics (or similar) for the specific new research goal. The author (based in Denmark) has to submit the application for ethical approval, with the external researcher(s) as named collaborator(s). In addition to ethical approval, a Collaboration Agreement and a Data Processing Agreement is required, both of which must be approved by the legal office of the institution of the author (data owner) and the legal office of the institution of the external researcher (data processor) External researchers (academic or commercial) interested in analyzing sequencing datasets on patient stem cells will need to contact the PASCAL-MID Data Access Committee via: bjmoell@rm.dk giehm@biomed.au.dk
Studies are experimental investigations of a particular phenomenon, e.g., case-control studies on a particular trait or cancer research projects reporting matching cancer normal genomes from patients.
| Study ID | Study Title | Study Type |
|---|---|---|
| EGAS50000001155 | Synthetic Genomics |
This table displays only public information pertaining to the files in the dataset. If you wish to access this dataset, please submit a request. If you already have access to these data files, please consult the download documentation.
| ID | File Type | Size | Quality Report |
Located in
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|---|---|---|---|---|
| EGAF50000405528 | fastq.gz | 1.2 MB |
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| EGAF50000405529 | fastq.gz | 1.1 MB |
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| EGAF50000405530 | fastq.gz | 1.0 MB |
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| EGAF50000405531 | fastq.gz | 1.1 MB |
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| EGAF50000405532 | fastq.gz | 1.3 MB |
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| EGAF50000405533 | fastq.gz | 1.3 MB |
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| EGAF50000405534 | fastq.gz | 1.3 MB |
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| EGAF50000405535 | fastq.gz | 1.3 MB |
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| EGAF50000405536 | fastq.gz | 1.1 MB |
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| EGAF50000405537 | fastq.gz | 1.2 MB |
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| EGAF50000405538 | fastq.gz | 1.4 MB |
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| EGAF50000405539 | fastq.gz | 1.5 MB |
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| EGAF50000405540 | fastq.gz | 1.3 MB |
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| EGAF50000405541 | fastq.gz | 1.4 MB |
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| EGAF50000405542 | fastq.gz | 1.1 MB |
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| EGAF50000405543 | fastq.gz | 1.3 MB |
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| EGAF50000405544 | fastq.gz | 1.4 MB |
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| EGAF50000405545 | fastq.gz | 1.5 MB |
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| EGAF50000405546 | fastq.gz | 1.3 MB |
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| EGAF50000405547 | fastq.gz | 1.5 MB |
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| EGAF50000405548 | fastq.gz | 1.2 MB |
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| EGAF50000405549 | fastq.gz | 1.3 MB |
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| EGAF50000405550 | fastq.gz | 1.7 MB |
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| EGAF50000405551 | fastq.gz | 2.0 MB |
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| EGAF50000405552 | fastq.gz | 1.7 MB |
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| EGAF50000405553 | fastq.gz | 2.0 MB |
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| EGAF50000405554 | fastq.gz | 1.6 MB |
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| EGAF50000405555 | fastq.gz | 1.9 MB |
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| EGAF50000405556 | fastq.gz | 1.7 MB |
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| EGAF50000405557 | fastq.gz | 2.0 MB |
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| EGAF50000405558 | fastq.gz | 1.8 MB |
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| EGAF50000405559 | fastq.gz | 2.1 MB |
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| EGAF50000405560 | fastq.gz | 1.6 MB |
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| EGAF50000405561 | fastq.gz | 1.9 MB |
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| EGAF50000405562 | fastq.gz | 1.7 MB |
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| EGAF50000405563 | fastq.gz | 2.0 MB |
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| EGAF50000405564 | fastq.gz | 1.7 MB |
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| EGAF50000405565 | fastq.gz | 1.8 MB |
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| EGAF50000405566 | fastq.gz | 1.5 MB |
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| EGAF50000405567 | fastq.gz | 1.6 MB |
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| EGAF50000405568 | fastq.gz | 1.4 MB |
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| EGAF50000405569 | fastq.gz | 1.6 MB |
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| EGAF50000405570 | fastq.gz | 2.0 MB |
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| EGAF50000405571 | fastq.gz | 2.0 MB |
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| EGAF50000405572 | fastq.gz | 1.9 MB |
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| EGAF50000405573 | fastq.gz | 2.0 MB |
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| EGAF50000405574 | fastq.gz | 2.2 MB |
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| EGAF50000405575 | fastq.gz | 2.3 MB |
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| EGAF50000405576 | fastq.gz | 1.3 MB |
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| EGAF50000405577 | fastq.gz | 1.4 MB |
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| EGAF50000405578 | fastq.gz | 1.4 MB |
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| EGAF50000405579 | fastq.gz | 1.5 MB |
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| EGAF50000405580 | fastq.gz | 1.2 MB |
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| EGAF50000405581 | fastq.gz | 1.3 MB |
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| EGAF50000405582 | fastq.gz | 1.7 MB |
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| EGAF50000405583 | fastq.gz | 1.8 MB |
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| EGAF50000405584 | fastq.gz | 2.0 MB |
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| EGAF50000405585 | fastq.gz | 1.9 MB |
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| EGAF50000405586 | fastq.gz | 1.9 MB |
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| EGAF50000405587 | fastq.gz | 2.1 MB |
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| EGAF50000405588 | fastq.gz | 3.3 MB |
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| EGAF50000405589 | fastq.gz | 3.6 MB |
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| EGAF50000405590 | fastq.gz | 3.3 MB |
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| EGAF50000405591 | fastq.gz | 3.6 MB |
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| EGAF50000405592 | fastq.gz | 3.2 MB |
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| EGAF50000405593 | fastq.gz | 3.5 MB |
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| EGAF50000405594 | fastq.gz | 4.5 MB |
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| EGAF50000405595 | fastq.gz | 5.1 MB |
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| EGAF50000405596 | fastq.gz | 5.1 MB |
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| EGAF50000405597 | fastq.gz | 4.5 MB |
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| EGAF50000405598 | fastq.gz | 4.4 MB |
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| EGAF50000405599 | fastq.gz | 5.1 MB |
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| EGAF50000405600 | fastq.gz | 4.0 MB |
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| EGAF50000405601 | fastq.gz | 4.3 MB |
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| EGAF50000405602 | fastq.gz | 4.7 MB |
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| EGAF50000405603 | fastq.gz | 4.4 MB |
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| EGAF50000405604 | fastq.gz | 4.2 MB |
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| EGAF50000405605 | fastq.gz | 4.5 MB |
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| EGAF50000405606 | fastq.gz | 3.7 MB |
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| EGAF50000405607 | fastq.gz | 3.4 MB |
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| EGAF50000405608 | fastq.gz | 3.6 MB |
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| EGAF50000405609 | fastq.gz | 3.3 MB |
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| EGAF50000405610 | fastq.gz | 3.5 MB |
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| EGAF50000405611 | fastq.gz | 3.2 MB |
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| EGAF50000405612 | fastq.gz | 1.6 MB |
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| EGAF50000405613 | fastq.gz | 1.4 MB |
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| EGAF50000405614 | fastq.gz | 1.2 MB |
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| EGAF50000405615 | fastq.gz | 1.4 MB |
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| EGAF50000405616 | fastq.gz | 1.3 MB |
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| EGAF50000405617 | fastq.gz | 1.5 MB |
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| EGAF50000405618 | fastq.gz | 3.2 MB |
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| EGAF50000405619 | fastq.gz | 3.7 MB |
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| EGAF50000405620 | fastq.gz | 3.3 MB |
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| EGAF50000405621 | fastq.gz | 2.9 MB |
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| EGAF50000405622 | fastq.gz | 2.2 MB |
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| EGAF50000405623 | fastq.gz | 2.5 MB |
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| EGAF50000405624 | fastq.gz | 2.8 MB |
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| EGAF50000405625 | fastq.gz | 3.3 MB |
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| EGAF50000405626 | fastq.gz | 2.1 MB |
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| EGAF50000405627 | fastq.gz | 2.4 MB |
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| EGAF50000405628 | fastq.gz | 2.5 MB |
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| EGAF50000405629 | fastq.gz | 2.9 MB |
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| EGAF50000405630 | fastq.gz | 3.9 MB |
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| EGAF50000405631 | fastq.gz | 4.2 MB |
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| EGAF50000405632 | fastq.gz | 3.6 MB |
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| EGAF50000405633 | fastq.gz | 3.9 MB |
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| EGAF50000405634 | fastq.gz | 3.5 MB |
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| EGAF50000405635 | fastq.gz | 3.8 MB |
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| EGAF50000405636 | fastq.gz | 3.2 MB |
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| EGAF50000405637 | fastq.gz | 3.6 MB |
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| EGAF50000405638 | fastq.gz | 3.8 MB |
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| EGAF50000405639 | fastq.gz | 4.2 MB |
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| EGAF50000405640 | fastq.gz | 3.2 MB |
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| EGAF50000405641 | fastq.gz | 3.5 MB |
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| EGAF50000405642 | fastq.gz | 1.3 MB |
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| EGAF50000405643 | fastq.gz | 982.6 kB |
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| EGAF50000405644 | fastq.gz | 948.0 kB |
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| EGAF50000405645 | fastq.gz | 1.2 MB |
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| EGAF50000405646 | fastq.gz | 809.7 kB |
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| EGAF50000405647 | fastq.gz | 1.1 MB |
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| EGAF50000405648 | fastq.gz | 967.4 kB |
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| EGAF50000405649 | fastq.gz | 1.2 MB |
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| EGAF50000405650 | fastq.gz | 1.0 MB |
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| EGAF50000405651 | fastq.gz | 1.3 MB |
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| EGAF50000405652 | fastq.gz | 1.4 MB |
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| EGAF50000405653 | fastq.gz | 1.1 MB |
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| EGAF50000405654 | fastq.gz | 1.1 MB |
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| EGAF50000405655 | fastq.gz | 1.3 MB |
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| EGAF50000405656 | fastq.gz | 1.3 MB |
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| EGAF50000405657 | fastq.gz | 1.0 MB |
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| EGAF50000405658 | fastq.gz | 999.1 kB |
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| EGAF50000405659 | fastq.gz | 1.3 MB |
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| EGAF50000405660 | fastq.gz | 1.1 MB |
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| EGAF50000405661 | fastq.gz | 1.4 MB |
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| EGAF50000405662 | fastq.gz | 1.1 MB |
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| EGAF50000405663 | fastq.gz | 1.4 MB |
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| EGAF50000405664 | fastq.gz | 1.1 MB |
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| EGAF50000405665 | fastq.gz | 1.3 MB |
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| EGAF50000405666 | fastq.gz | 1.4 MB |
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| EGAF50000405667 | fastq.gz | 1.7 MB |
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| EGAF50000405668 | fastq.gz | 1.2 MB |
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| EGAF50000405669 | fastq.gz | 1.4 MB |
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| EGAF50000405670 | fastq.gz | 1.5 MB |
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| EGAF50000405671 | fastq.gz | 1.7 MB |
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| EGAF50000405672 | fastq.gz | 56.1 MB |
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| EGAF50000405673 | fastq.gz | 63.7 MB |
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| EGAF50000405674 | fastq.gz | 52.8 MB |
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| EGAF50000405675 | fastq.gz | 63.0 MB |
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| EGAF50000405676 | fastq.gz | 52.6 MB |
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| EGAF50000405677 | fastq.gz | 51.8 MB |
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| EGAF50000405678 | fastq.gz | 55.2 MB |
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| EGAF50000405679 | fastq.gz | 53.9 MB |
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| EGAF50000405680 | fastq.gz | 55.5 MB |
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| EGAF50000405681 | fastq.gz | 43.7 MB |
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| EGAF50000405682 | fastq.gz | 43.2 MB |
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| EGAF50000405683 | fastq.gz | 46.4 MB |
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| EGAF50000405684 | fastq.gz | 65.7 MB |
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| EGAF50000405685 | fastq.gz | 56.1 MB |
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| EGAF50000405686 | fastq.gz | 56.5 MB |
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| EGAF50000405687 | fastq.gz | 65.1 MB |
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| EGAF50000405688 | fastq.gz | 55.2 MB |
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| EGAF50000405689 | fastq.gz | 56.6 MB |
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| EGAF50000405690 | fastq.gz | 1.4 MB |
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| EGAF50000405691 | fastq.gz | 1.7 MB |
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| EGAF50000405692 | fastq.gz | 1.3 MB |
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| EGAF50000405693 | fastq.gz | 1.6 MB |
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| EGAF50000405694 | fastq.gz | 938.1 kB |
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| EGAF50000405695 | fastq.gz | 1.1 MB |
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| EGAF50000405696 | fastq.gz | 1.3 MB |
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| EGAF50000405697 | fastq.gz | 1.3 MB |
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| EGAF50000405698 | fastq.gz | 2.0 MB |
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| EGAF50000405699 | fastq.gz | 1.7 MB |
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| EGAF50000405700 | fastq.gz | 1.7 MB |
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| EGAF50000405701 | fastq.gz | 2.0 MB |
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| EGAF50000405702 | fastq.gz | 1.7 MB |
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| EGAF50000405703 | fastq.gz | 2.0 MB |
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| EGAF50000405704 | fastq.gz | 1.8 MB |
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| EGAF50000405705 | fastq.gz | 1.6 MB |
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| EGAF50000405706 | fastq.gz | 1.8 MB |
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| EGAF50000405707 | fastq.gz | 2.0 MB |
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| EGAF50000405708 | fastq.gz | 2.8 MB |
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| EGAF50000405709 | fastq.gz | 3.1 MB |
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| EGAF50000405710 | fastq.gz | 2.1 MB |
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| EGAF50000405711 | fastq.gz | 2.5 MB |
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| EGAF50000405712 | fastq.gz | 2.9 MB |
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| EGAF50000405713 | fastq.gz | 3.1 MB |
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| EGAF50000405714 | fastq.gz | 2.3 MB |
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| EGAF50000405715 | fastq.gz | 2.6 MB |
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| EGAF50000405716 | fastq.gz | 2.7 MB |
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| EGAF50000405717 | fastq.gz | 3.0 MB |
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| EGAF50000405718 | fastq.gz | 2.4 MB |
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| EGAF50000405719 | fastq.gz | 2.8 MB |
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| EGAF50000405720 | fastq.gz | 2.3 MB |
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| EGAF50000405721 | fastq.gz | 2.7 MB |
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| EGAF50000405722 | fastq.gz | 2.6 MB |
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| EGAF50000405723 | fastq.gz | 2.6 MB |
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| EGAF50000405724 | fastq.gz | 2.5 MB |
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| EGAF50000405725 | fastq.gz | 3.0 MB |
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| EGAF50000405726 | fastq.gz | 2.4 MB |
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| EGAF50000405727 | fastq.gz | 2.5 MB |
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| EGAF50000405728 | fastq.gz | 3.1 MB |
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| EGAF50000405729 | fastq.gz | 2.6 MB |
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| EGAF50000405730 | fastq.gz | 2.8 MB |
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| EGAF50000405731 | fastq.gz | 2.7 MB |
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| EGAF50000405732 | fastq.gz | 1.9 MB |
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| EGAF50000405733 | fastq.gz | 2.2 MB |
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| EGAF50000405734 | fastq.gz | 1.9 MB |
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| EGAF50000405735 | fastq.gz | 2.2 MB |
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| EGAF50000405736 | fastq.gz | 2.2 MB |
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| EGAF50000405737 | fastq.gz | 1.8 MB |
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| EGAF50000405738 | fastq.gz | 1.9 MB |
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| EGAF50000405739 | fastq.gz | 2.3 MB |
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| EGAF50000405740 | fastq.gz | 1.8 MB |
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| EGAF50000405741 | fastq.gz | 2.1 MB |
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| EGAF50000405742 | fastq.gz | 1.7 MB |
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| EGAF50000405743 | fastq.gz | 2.0 MB |
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| EGAF50000405744 | fastq.gz | 11.0 MB |
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| EGAF50000405745 | fastq.gz | 11.4 MB |
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| EGAF50000405746 | fastq.gz | 9.7 MB |
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| EGAF50000405747 | fastq.gz | 10.1 MB |
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| EGAF50000405748 | fastq.gz | 9.1 MB |
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| EGAF50000405749 | fastq.gz | 9.4 MB |
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| EGAF50000405750 | fastq.gz | 10.5 MB |
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| EGAF50000405751 | fastq.gz | 10.9 MB |
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| EGAF50000405752 | fastq.gz | 9.3 MB |
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| EGAF50000405753 | fastq.gz | 9.6 MB |
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| EGAF50000405754 | fastq.gz | 9.4 MB |
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| EGAF50000405755 | fastq.gz | 9.7 MB |
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| EGAF50000405756 | fastq.gz | 10.3 MB |
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| EGAF50000405757 | fastq.gz | 10.6 MB |
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| EGAF50000405758 | fastq.gz | 9.5 MB |
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| EGAF50000405759 | fastq.gz | 9.8 MB |
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| EGAF50000405760 | fastq.gz | 9.4 MB |
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| EGAF50000405761 | fastq.gz | 9.7 MB |
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| EGAF50000405762 | fastq.gz | 713.2 MB |
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| EGAF50000405763 | fastq.gz | 701.9 MB |
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| EGAF50000405764 | fastq.gz | 744.2 MB |
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| EGAF50000405765 | fastq.gz | 778.9 MB |
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| EGAF50000405766 | fastq.gz | 765.3 MB |
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| EGAF50000405767 | fastq.gz | 746.9 MB |
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| EGAF50000405768 | fastq.gz | 610.6 MB |
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| EGAF50000405769 | fastq.gz | 651.6 MB |
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| EGAF50000405770 | fastq.gz | 697.2 MB |
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| EGAF50000405771 | fastq.gz | 767.7 MB |
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| EGAF50000405772 | fastq.gz | 753.2 MB |
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| EGAF50000405773 | fastq.gz | 796.4 MB |
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| EGAF50000405774 | fastq.gz | 710.0 MB |
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| EGAF50000405775 | fastq.gz | 757.1 MB |
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| EGAF50000405776 | fastq.gz | 811.5 MB |
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| EGAF50000405777 | fastq.gz | 838.0 MB |
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| EGAF50000405778 | fastq.gz | 614.0 MB |
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| EGAF50000405779 | fastq.gz | 653.5 MB |
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| EGAF50000405780 | fastq.gz | 691.2 MB |
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| EGAF50000405781 | fastq.gz | 708.1 MB |
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| 254 Files (16.1 GB) | ||||