IGH repertoire sequencing of GZMB+ and GZMB− B cells

This dataset contains high-throughput sequencing data of immunoglobulin heavy chain (IGH) repertoires from sorted GZMB⁺ and GZMB⁻ B cell subsets. Samples were obtained from healthy donors (Healthy Volunteers, HVs) and drug-free tolerant kidney transplant recipients (TOLs). Libraries were generated from genomic DNA using targeted BIOMED-2 PCR amplification and sequenced on an Illumina MiSeq platform. The dataset enables comparative analysis of B cell clonality, diversity, and somatic hypermutation patterns.

13/04/2026
8 samples
DAC: EGAC50000000217
Technology: Illumina MiSeq

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Studies are experimental investigations of a particular phenomenon, e.g., case-control studies on a particular trait or cancer research projects reporting matching cancer normal genomes from patients.

Study ID	Study Title	Study Type
EGAS50000001707	Granzyme B-expressing regulatory B cells share the same origin as conventional blood B cells	Exome Sequencing

This table displays only public information pertaining to the files in the dataset. If you wish to access this dataset, please submit a request. If you already have access to these data files, please consult the download documentation.

ID	File Type	Size
EGAF50000707000	fastq.gz	31.6 MB
EGAF50000707001	fastq.gz	42.5 MB
EGAF50000707002	fastq.gz	71.0 MB
EGAF50000707003	fastq.gz	98.1 MB
EGAF50000707004	fastq.gz	50.6 MB
EGAF50000707005	fastq.gz	70.4 MB
EGAF50000707006	fastq.gz	41.3 MB
EGAF50000707007	fastq.gz	28.5 MB
EGAF50000707008	fastq.gz	42.3 MB
EGAF50000707009	fastq.gz	33.6 MB
EGAF50000707010	fastq.gz	58.5 MB
EGAF50000707011	fastq.gz	23.6 MB
EGAF50000707012	fastq.gz	73.7 MB
EGAF50000707013	fastq.gz	52.5 MB
EGAF50000707014	fastq.gz	48.9 MB
EGAF50000707015	fastq.gz	71.2 MB
16 Files (838.2 MB)