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Prefibrotic Bone Marrow Microenvironment is a Hallmark of Clonal Hematopoiesis

single-cell RNA-seq on BM (Niche and Hematopoeitic) from male (n=10) and female donors (n=5) aged 52-84 years undergoing elective hip replacement surgery.

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Access to data generated by UHN is made available by completing the data access agreement for review by the data access committee and will be granted to qualified investigators for appropriate use.

DATA ACCESS AGREEMENT These terms and conditions govern access to the managed access datasets (details of which are set out in Appendix I) to which the User Institution has requested access. The User Institution agrees to be bound by these terms and conditions. Definitions Authorised Personnel: The individuals at the User Institution to whom the Data Access Committee (DAC) grants access to the Data. This includes the User, the individuals listed in Appendix II and any other individuals for whom the User Institution subsequently requests access to the Data. Details of the initial Authorised Personnel are set out in Appendix II. Data: The managed access datasets to which the User Institution has requested access. Data Producers: The Principal Investigator and the collaborators listed in Appendix I responsible for the development, organisation, and oversight of these Data. External Collaborator: A collaborator of the User, working for an institution other than the User Institution. Project: The project for which the User Institution has requested access to these Data. A description of the Project is set out in Appendix II. Publications: Includes, without limitation, articles published in print journals, electronic journals, reviews, books, posters and other written and verbal presentations of research. Research Participant: An individual whose data form part of these Data. Research Purposes: Shall mean research that is seeking to advance the understanding of genetics and genomics, including the treatment of disorders, and work on statistical methods that may be applied to such research. User: The principal investigator for the Project. User Institution(s): The Institution that has requested access to the Data. University Health Network: The University Health Network (UHN) is the largest clinical and research hospital in Canada. UHN is affiliated with the University of Toronto and is a member of the Toronto Academic Health Science Network. 1. The User Institution agrees to only use these Data for the purpose of the Project (described in Appendix II) and only for Research Purposes. The User Institution further agrees that it will only use these Data for Research Purposes which are within the limitations (if any) set out in Appendix I. 2. The User Institution agrees to preserve, at all times, the confidentiality of these Data. In particular, it undertakes not to use, or attempt to use these Data to compromise or otherwise infringe the confidentiality of information on Research Participants. Without prejudice to the generality of the foregoing, the User Institution agrees to use at least the measures set out in Appendix I to protect these Data. 3. The User Institution agrees to protect the confidentiality of Research Participants in any research papers or publications that they prepare by taking all reasonable care to limit the possibility of identification. 4. The User Institution agrees not to link or combine these Data to other information or archived data available in a way that could re-identify the Research Participants, even if access to that data has been formally granted to the User Institution or is freely available without restriction. 5. The User Institution agrees only to transfer or disclose these Data, in whole or part, or any material derived from these Data, to the Authorised Personnel. Should the User Institution wish to share these Data with an External Collaborator, the External Collaborator must complete a separate application for access to these Data. 6. The User Institution agrees that the Data Producers, and all other parties involved in the creation, funding or protection of these Data: a) make no warranty or representation, express or implied as to the accuracy, quality or comprehensiveness of these Data; b) exclude to the fullest extent permitted by law all liability for actions, claims, proceedings, demands, losses (including but not limited to loss of profit), costs, awards damages and payments made by the Recipient that may arise (whether directly or indirectly) in any way whatsoever from the Recipient’s use of these Data or from the unavailability of, or break in access to, these Data for whatever reason and; c) bear no responsibility for the further analysis or interpretation of these Data. 7. The User Institution agrees to follow the Fort Lauderdale Guidelines (http://www.wellcome.ac.uk/stellent/groups/corporatesite/@policy_communications/documents/web_document/wtd003207.pdf ) and the Toronto Statement (http://www.nature.com/nature/journal/v461/n7261/full/461168a.html). This includes but is not limited to recognising the contribution of the Data Producers and including a proper acknowledgement in all reports or publications resulting from the use of these Data. 8. The User Institution agrees to follow the Publication Policy in Appendix III. This includes respecting the moratorium period for the Data Producers to publish the first peer-reviewed report describing and analysing these Data. 9. The User Institution agrees not to make intellectual property claims on these Data and not to use intellectual property protection in ways that would prevent or block access to, or use of, any element of these Data, or conclusion drawn directly from these Data. 10. The User Institution can elect to perform further research that would add intellectual and resource capital to these data and decide to obtain intellectual property rights on these downstream discoveries. In this case, the User Institution agrees to implement licensing policies that will not obstruct further research and to follow the U.S. National Institutes of Health Best Practices for the Licensing of Genomic Inventions (2005) (https://www.icgc.org/files/daco/NIH_BestPracticesLicensingGenomicInventions_2005_en.pdf ) in conformity with the Organisation for Economic Co-operation and Development Guidelines for the Licensing of the Genetic Inventions (2006) (http://www.oecd.org/science/biotech/36198812.pdf ). 11. The User Institution agrees to destroy/discard the Data held, once it is no longer used for the Project, unless obliged to retain the data for archival purposes in conformity with audit or legal requirements. 12. The User Institution will notify the DAC within 30 days of any changes or departures of Authorised Personnel. 13. The User Institution will notify the DAC prior to any significant changes to the protocol for the Project. 14. The User Institution will notify the DAC as soon as it becomes aware of a breach of the terms or conditions of this agreement. 15. The DAC may terminate this agreement by written notice to the User Institution. If this agreement terminates for any reason, the User Institution will be required to destroy any Data held, including copies and backup copies. This clause does not prevent the User Institution from retaining these data for archival purpose in conformity with audit or legal requirements. 16. The User Institution accepts that it may be necessary for the Data Producers to alter the terms of this agreement from time to time. In the event that changes are required, the Data Producers or their appointed agent will contact the User Institution to inform it of the changes and the User Institution may elect to accept the changes or terminate the agreement. 17. If requested, the User Institution will allow data security and management documentation to be inspected to verify that it is complying with the terms of this agreement. 18. The User Institution agrees to distribute a copy of these terms to the Authorised Personnel. The User Institution will procure that the Authorised Personnel comply with the terms of this agreement. 19. This agreement (and any dispute, controversy, proceedings or claim of whatever nature arising out of this agreement or its formation) shall be construed, interpreted and governed by the laws of the province of Ontario and PHIPA. Agreed for User Institution Signature: Name: Title: Date: Principal Investigator I confirm that I have read and understood this Agreement. Signature: Name: Title: Date: Agreed for The Data Access Committee Signature: Name: Title: Date: APPENDIX I – DATASET DETAILS APPENDIX II ––PROJECT DETAILS APPENDIX III –– PUBLICATION POLICY

Studies are experimental investigations of a particular phenomenon, e.g., case-control studies on a particular trait or cancer research projects reporting matching cancer normal genomes from patients.

Study ID Study Title Study Type
EGAS50000001774 Transcriptome Sequencing

This table displays only public information pertaining to the files in the dataset. If you wish to access this dataset, please submit a request. If you already have access to these data files, please consult the download documentation.

ID File Type Size Quality Report
Located in
EGAF50000807025 fastq.gz 4.8 GB
EGAF50000807026 fastq.gz 10.2 GB
EGAF50000807027 fastq.gz 5.0 GB
EGAF50000807028 fastq.gz 10.5 GB
EGAF50000807029 fastq.gz 4.9 GB
EGAF50000807030 fastq.gz 10.3 GB
EGAF50000807031 fastq.gz 4.8 GB
EGAF50000807032 fastq.gz 10.2 GB
EGAF50000807033 fastq.gz 575.4 MB
EGAF50000807034 fastq.gz 1.2 GB
EGAF50000807035 fastq.gz 567.5 MB
EGAF50000807036 fastq.gz 1.2 GB
EGAF50000807037 fastq.gz 558.0 MB
EGAF50000807038 fastq.gz 1.2 GB
EGAF50000807039 fastq.gz 546.4 MB
EGAF50000807040 fastq.gz 1.2 GB
EGAF50000807041 fastq.gz 559.6 MB
EGAF50000807042 fastq.gz 1.2 GB
EGAF50000807043 fastq.gz 572.5 MB
EGAF50000807044 fastq.gz 1.2 GB
EGAF50000807045 fastq.gz 1.2 GB
EGAF50000807046 fastq.gz 561.5 MB
EGAF50000807047 fastq.gz 560.3 MB
EGAF50000807048 fastq.gz 1.2 GB
EGAF50000807049 fastq.gz 568.4 MB
EGAF50000807050 fastq.gz 1.2 GB
EGAF50000807051 fastq.gz 566.4 MB
EGAF50000807052 fastq.gz 1.2 GB
EGAF50000807053 fastq.gz 553.1 MB
EGAF50000807054 fastq.gz 1.2 GB
EGAF50000807055 fastq.gz 538.0 MB
EGAF50000807056 fastq.gz 1.1 GB
EGAF50000807057 fastq.gz 554.2 MB
EGAF50000807058 fastq.gz 1.2 GB
EGAF50000807059 fastq.gz 564.9 MB
EGAF50000807060 fastq.gz 1.2 GB
EGAF50000807061 fastq.gz 554.3 MB
EGAF50000807062 fastq.gz 1.2 GB
EGAF50000807063 fastq.gz 549.8 MB
EGAF50000807064 fastq.gz 1.2 GB
EGAF50000807065 fastq.gz 1.6 GB
EGAF50000807066 fastq.gz 3.4 GB
EGAF50000807067 fastq.gz 1.6 GB
EGAF50000807068 fastq.gz 3.3 GB
EGAF50000807069 fastq.gz 1.9 GB
EGAF50000807070 fastq.gz 4.0 GB
EGAF50000807071 fastq.gz 1.9 GB
EGAF50000807072 fastq.gz 3.9 GB
EGAF50000807073 fastq.gz 1.9 GB
EGAF50000807074 fastq.gz 3.9 GB
EGAF50000807075 fastq.gz 1.9 GB
EGAF50000807076 fastq.gz 3.9 GB
EGAF50000807077 fastq.gz 1.8 GB
EGAF50000807078 fastq.gz 3.8 GB
EGAF50000807079 fastq.gz 726.4 MB
EGAF50000807080 fastq.gz 1.3 GB
EGAF50000807081 fastq.gz 722.0 MB
EGAF50000807082 fastq.gz 1.3 GB
EGAF50000807083 fastq.gz 708.3 MB
EGAF50000807084 fastq.gz 1.2 GB
EGAF50000807085 fastq.gz 4.1 GB
EGAF50000807086 fastq.gz 8.6 GB
EGAF50000807087 fastq.gz 4.1 GB
EGAF50000807088 fastq.gz 8.7 GB
EGAF50000807089 fastq.gz 4.1 GB
EGAF50000807090 fastq.gz 8.7 GB
EGAF50000807091 fastq.gz 4.2 GB
EGAF50000807092 fastq.gz 8.8 GB
EGAF50000807093 fastq.gz 3.8 GB
EGAF50000807094 fastq.gz 2.1 GB
EGAF50000807095 fastq.gz 2.0 GB
EGAF50000807096 fastq.gz 3.7 GB
EGAF50000807097 fastq.gz 2.0 GB
EGAF50000807098 fastq.gz 3.6 GB
EGAF50000807099 fastq.gz 1.9 GB
EGAF50000807100 fastq.gz 3.5 GB
EGAF50000807101 fastq.gz 4.0 GB
EGAF50000807102 fastq.gz 8.5 GB
EGAF50000807103 fastq.gz 4.0 GB
EGAF50000807104 fastq.gz 8.5 GB
EGAF50000807105 fastq.gz 8.6 GB
EGAF50000807106 fastq.gz 4.0 GB
EGAF50000807107 fastq.gz 4.0 GB
EGAF50000807108 fastq.gz 8.5 GB
EGAF50000807109 fastq.gz 3.9 GB
EGAF50000807110 fastq.gz 8.3 GB
EGAF50000807111 fastq.gz 737.6 MB
EGAF50000807112 fastq.gz 1.3 GB
EGAF50000807113 fastq.gz 729.4 MB
EGAF50000807114 fastq.gz 1.3 GB
EGAF50000807115 fastq.gz 835.5 MB
EGAF50000807116 fastq.gz 1.5 GB
EGAF50000807117 fastq.gz 1.4 GB
EGAF50000807118 fastq.gz 762.6 MB
EGAF50000807119 fastq.gz 715.7 MB
EGAF50000807120 fastq.gz 1.3 GB
EGAF50000807121 fastq.gz 2.6 GB
EGAF50000807122 fastq.gz 5.6 GB
EGAF50000807123 fastq.gz 2.5 GB
EGAF50000807124 fastq.gz 5.5 GB
EGAF50000807125 fastq.gz 2.6 GB
EGAF50000807126 fastq.gz 5.6 GB
EGAF50000807127 fastq.gz 2.7 GB
EGAF50000807128 fastq.gz 5.8 GB
EGAF50000807129 fastq.gz 5.7 GB
EGAF50000807130 fastq.gz 2.7 GB
EGAF50000807131 fastq.gz 2.6 GB
EGAF50000807132 fastq.gz 5.6 GB
EGAF50000807133 fastq.gz 5.7 GB
EGAF50000807134 fastq.gz 2.6 GB
EGAF50000807135 fastq.gz 5.6 GB
EGAF50000807136 fastq.gz 2.6 GB
EGAF50000807137 fastq.gz 448.0 MB
EGAF50000807138 fastq.gz 880.2 MB
EGAF50000807139 fastq.gz 461.8 MB
EGAF50000807140 fastq.gz 907.3 MB
EGAF50000807141 fastq.gz 858.9 MB
EGAF50000807142 fastq.gz 436.7 MB
EGAF50000807143 fastq.gz 403.2 MB
EGAF50000807144 fastq.gz 788.5 MB
EGAF50000807145 fastq.gz 416.6 MB
EGAF50000807146 fastq.gz 814.5 MB
EGAF50000807147 fastq.gz 461.0 MB
EGAF50000807148 fastq.gz 902.5 MB
EGAF50000807149 fastq.gz 429.4 MB
EGAF50000807150 fastq.gz 839.6 MB
EGAF50000807151 fastq.gz 437.5 MB
EGAF50000807152 fastq.gz 855.8 MB
EGAF50000807153 fastq.gz 1.6 GB
EGAF50000807154 fastq.gz 3.5 GB
EGAF50000807155 fastq.gz 1.6 GB
EGAF50000807156 fastq.gz 3.4 GB
EGAF50000807157 fastq.gz 1.9 GB
EGAF50000807158 fastq.gz 4.0 GB
EGAF50000807159 fastq.gz 4.0 GB
EGAF50000807160 fastq.gz 1.9 GB
EGAF50000807161 fastq.gz 2.0 GB
EGAF50000807162 fastq.gz 4.1 GB
EGAF50000807163 fastq.gz 1.9 GB
EGAF50000807164 fastq.gz 4.0 GB
EGAF50000807165 fastq.gz 1.9 GB
EGAF50000807166 fastq.gz 4.0 GB
EGAF50000807167 fastq.gz 518.5 MB
EGAF50000807168 fastq.gz 900.4 MB
EGAF50000807169 fastq.gz 515.8 MB
EGAF50000807170 fastq.gz 902.3 MB
EGAF50000807171 fastq.gz 885.7 MB
EGAF50000807172 fastq.gz 508.1 MB
EGAF50000807173 fastq.gz 5.0 GB
EGAF50000807174 fastq.gz 10.7 GB
EGAF50000807175 fastq.gz 10.9 GB
EGAF50000807176 fastq.gz 5.0 GB
EGAF50000807177 fastq.gz 5.1 GB
EGAF50000807178 fastq.gz 11.0 GB
EGAF50000807179 fastq.gz 5.2 GB
EGAF50000807180 fastq.gz 11.2 GB
EGAF50000807181 fastq.gz 1.8 GB
EGAF50000807182 fastq.gz 3.2 GB
EGAF50000807183 fastq.gz 3.1 GB
EGAF50000807184 fastq.gz 1.7 GB
EGAF50000807185 fastq.gz 3.0 GB
EGAF50000807186 fastq.gz 1.6 GB
EGAF50000807187 fastq.gz 1.6 GB
EGAF50000807188 fastq.gz 2.8 GB
EGAF50000807189 fastq.gz 3.9 GB
EGAF50000807190 fastq.gz 8.3 GB
EGAF50000807191 fastq.gz 8.4 GB
EGAF50000807192 fastq.gz 3.9 GB
EGAF50000807193 fastq.gz 3.8 GB
EGAF50000807194 fastq.gz 8.3 GB
EGAF50000807195 fastq.gz 8.3 GB
EGAF50000807196 fastq.gz 3.9 GB
EGAF50000807197 fastq.gz 3.8 GB
EGAF50000807198 fastq.gz 8.2 GB
EGAF50000807199 fastq.gz 1.5 GB
EGAF50000807200 fastq.gz 836.9 MB
EGAF50000807201 fastq.gz 825.7 MB
EGAF50000807202 fastq.gz 1.5 GB
EGAF50000807203 fastq.gz 942.0 MB
EGAF50000807204 fastq.gz 1.7 GB
EGAF50000807205 fastq.gz 865.4 MB
EGAF50000807206 fastq.gz 1.6 GB
EGAF50000807207 fastq.gz 817.2 MB
EGAF50000807208 fastq.gz 1.5 GB
EGAF50000807209 fastq.gz 2.7 GB
EGAF50000807210 fastq.gz 5.8 GB
EGAF50000807211 fastq.gz 2.7 GB
EGAF50000807212 fastq.gz 5.7 GB
EGAF50000807213 fastq.gz 2.8 GB
EGAF50000807214 fastq.gz 5.9 GB
EGAF50000807215 fastq.gz 2.9 GB
EGAF50000807216 fastq.gz 6.2 GB
EGAF50000807217 fastq.gz 6.0 GB
EGAF50000807218 fastq.gz 2.8 GB
EGAF50000807219 fastq.gz 2.7 GB
EGAF50000807220 fastq.gz 5.7 GB
EGAF50000807221 fastq.gz 2.8 GB
EGAF50000807222 fastq.gz 5.9 GB
EGAF50000807223 fastq.gz 5.9 GB
EGAF50000807224 fastq.gz 2.8 GB
EGAF50000807225 fastq.gz 589.9 MB
EGAF50000807226 fastq.gz 1.2 GB
EGAF50000807227 fastq.gz 610.0 MB
EGAF50000807228 fastq.gz 1.2 GB
EGAF50000807229 fastq.gz 576.3 MB
EGAF50000807230 fastq.gz 1.1 GB
EGAF50000807231 fastq.gz 528.9 MB
EGAF50000807232 fastq.gz 1.0 GB
EGAF50000807233 fastq.gz 1.1 GB
EGAF50000807234 fastq.gz 550.3 MB
EGAF50000807235 fastq.gz 607.7 MB
EGAF50000807236 fastq.gz 1.2 GB
EGAF50000807237 fastq.gz 569.4 MB
EGAF50000807238 fastq.gz 1.1 GB
EGAF50000807239 fastq.gz 574.7 MB
EGAF50000807240 fastq.gz 1.1 GB
EGAF50000807241 fastq.gz 1.6 GB
EGAF50000807242 fastq.gz 3.4 GB
EGAF50000807243 fastq.gz 1.6 GB
EGAF50000807244 fastq.gz 3.4 GB
EGAF50000807245 fastq.gz 1.6 GB
EGAF50000807246 fastq.gz 3.4 GB
EGAF50000807247 fastq.gz 1.6 GB
EGAF50000807248 fastq.gz 3.4 GB
EGAF50000807249 fastq.gz 1.6 GB
EGAF50000807250 fastq.gz 3.4 GB
EGAF50000807251 fastq.gz 1.6 GB
EGAF50000807252 fastq.gz 3.3 GB
EGAF50000807253 fastq.gz 1.6 GB
EGAF50000807254 fastq.gz 3.3 GB
EGAF50000807255 fastq.gz 3.4 GB
EGAF50000807256 fastq.gz 1.6 GB
EGAF50000807257 fastq.gz 2.4 GB
EGAF50000807258 fastq.gz 1.1 GB
EGAF50000807259 fastq.gz 1.1 GB
EGAF50000807260 fastq.gz 2.4 GB
EGAF50000807261 fastq.gz 1.1 GB
EGAF50000807262 fastq.gz 2.3 GB
EGAF50000807263 fastq.gz 1.1 GB
EGAF50000807264 fastq.gz 2.3 GB
EGAF50000807265 fastq.gz 1.1 GB
EGAF50000807266 fastq.gz 2.3 GB
EGAF50000807267 fastq.gz 1.1 GB
EGAF50000807268 fastq.gz 2.4 GB
EGAF50000807269 fastq.gz 1.1 GB
EGAF50000807270 fastq.gz 2.3 GB
EGAF50000807271 fastq.gz 1.1 GB
EGAF50000807272 fastq.gz 2.3 GB
EGAF50000807273 fastq.gz 3.8 GB
EGAF50000807274 fastq.gz 8.3 GB
EGAF50000807275 fastq.gz 3.8 GB
EGAF50000807276 fastq.gz 8.2 GB
EGAF50000807277 fastq.gz 3.8 GB
EGAF50000807278 fastq.gz 8.0 GB
EGAF50000807279 fastq.gz 3.7 GB
EGAF50000807280 fastq.gz 7.9 GB
EGAF50000807281 fastq.gz 3.8 GB
EGAF50000807282 fastq.gz 8.0 GB
EGAF50000807283 fastq.gz 3.9 GB
EGAF50000807284 fastq.gz 8.3 GB
EGAF50000807285 fastq.gz 2.5 GB
EGAF50000807286 fastq.gz 5.4 GB
EGAF50000807287 fastq.gz 2.5 GB
EGAF50000807288 fastq.gz 5.4 GB
EGAF50000807289 fastq.gz 2.5 GB
EGAF50000807290 fastq.gz 5.4 GB
EGAF50000807291 fastq.gz 2.5 GB
EGAF50000807292 fastq.gz 5.5 GB
EGAF50000807293 fastq.gz 2.1 GB
EGAF50000807294 fastq.gz 4.6 GB
EGAF50000807295 fastq.gz 4.4 GB
EGAF50000807296 fastq.gz 2.0 GB
EGAF50000807297 fastq.gz 2.1 GB
EGAF50000807298 fastq.gz 4.6 GB
EGAF50000807299 fastq.gz 2.1 GB
EGAF50000807300 fastq.gz 4.5 GB
EGAF50000807301 fastq.gz 1.1 GB
EGAF50000807302 fastq.gz 2.5 GB
EGAF50000807303 fastq.gz 1.2 GB
EGAF50000807304 fastq.gz 2.5 GB
EGAF50000807305 fastq.gz 1.2 GB
EGAF50000807306 fastq.gz 2.5 GB
EGAF50000807307 fastq.gz 2.4 GB
EGAF50000807308 fastq.gz 1.1 GB
EGAF50000807309 fastq.gz 2.5 GB
EGAF50000807310 fastq.gz 1.1 GB
EGAF50000807311 fastq.gz 1.1 GB
EGAF50000807312 fastq.gz 2.5 GB
EGAF50000807313 fastq.gz 1.2 GB
EGAF50000807314 fastq.gz 2.5 GB
EGAF50000807315 fastq.gz 1.2 GB
EGAF50000807316 fastq.gz 2.5 GB
EGAF50000807317 fastq.gz 2.7 GB
EGAF50000807318 fastq.gz 5.7 GB
EGAF50000807319 fastq.gz 2.6 GB
EGAF50000807320 fastq.gz 5.6 GB
EGAF50000807321 fastq.gz 2.5 GB
EGAF50000807322 fastq.gz 5.1 GB
EGAF50000807323 fastq.gz 2.5 GB
EGAF50000807324 fastq.gz 5.2 GB
EGAF50000807325 fastq.gz 3.0 GB
EGAF50000807326 fastq.gz 6.2 GB
EGAF50000807327 fastq.gz 3.0 GB
EGAF50000807328 fastq.gz 6.2 GB
EGAF50000807329 fastq.gz 2.9 GB
EGAF50000807330 fastq.gz 6.0 GB
EGAF50000807331 fastq.gz 4.4 GB
EGAF50000807332 fastq.gz 9.2 GB
EGAF50000807333 fastq.gz 3.0 GB
EGAF50000807334 fastq.gz 6.3 GB
EGAF50000807335 fastq.gz 2.4 GB
EGAF50000807336 fastq.gz 5.0 GB
EGAF50000807337 fastq.gz 2.5 GB
EGAF50000807338 fastq.gz 5.1 GB
EGAF50000807339 fastq.gz 2.4 GB
EGAF50000807340 fastq.gz 5.0 GB
EGAF50000807341 fastq.gz 2.4 GB
EGAF50000807342 fastq.gz 5.0 GB
318 Files (977.0 GB)