Search Results - EGA European Genome-Phenome Archive

Monotherapy Breast Cancer

These samples are from locally advanced breast cancers that have been treated with epirubicin monotherapy before surgery. We will sequence some samples from patients with good response to the therapy and some with poor response to the therapy.

Dataset EGAD00001000349

Transcriptome Sequencing of Cancer Cell Lines

In this study we will sequence the transcriptome of Verified Cancer Cell lines. This will be married up to whole exome and whole genome sequencing data to establish a full catalog of the variations and mutations found.

Dataset EGAD00001000359

Targeted gene fusion sequencing (Fus-seq) in mesothelioma

This is a small pilot data set to test the feasibility of cDNA exomes across 1200 cancer cell line panel. cDNA exomes or Fus-seq is further explained in this studies Abstract.

Dataset EGAD00001000361

Lung Plasma rearrangement screen

Genomic libraries (500 bps) will be generated from total genomic DNA derived from lung cancer patients and subjected to short paired end sequencing on the llumina platform. Paired reads will be mapped to build 37 of the human reference genome to facilitate the generation of genome wide copy number information, and the identification of novel rearranged cancer genes and gene fusions.

Dataset EGAD00001000367

A common single nucleotide variant in T is strongly associated with chordoma

Chordoma is a rare malignant bone tumor that expresses the transcription factor T. We conducted an association study of 40 patients with chordoma and 358 ancestry-matched, unaffected individuals with replication in an independent cohort. Whole-exome and Sanger sequencing of T exons reveals a strong risk association ( allelic odds ratio (OR) = 4.9, P = 3.3x10-11, CI= 2.9-8.1) with the common (minor allelic frequency >5%) non-synonymous SNP rs2305089 in chordoma, which is exceptional in cancer genetics.

Dataset EGAD00001000226

Testing the feasibility of genome scale sequencing in routinely collected FFPE cancer specimens versus matched fresh frozen samples

Dataset EGAD00001000255

OICR PANCREATIC CANCER DATASET

Dataset EGAD00001000262

ICGC Prostate Cancer Whole Genome Sequencing

A small subsample of EGAD00001000689. Please do not use.

Dataset EGAD00001000263

Genetic mechanisms of resistance to chemotherapy in breast cancer

Resistance towards chemotherapy is one of the main causes of treatment failure and deathamong breast cancer patients.The main objective of this project is toidentify genetic mechanisms causing some breast cancer patients not torespond to a particluar type of chemotherapy (epirubicin) while otherpatients respond very well to the same treatment. In the project wewill perform genome / exome sequencing of a selection of breast cancerpatients (n=30). These patients are drawn from a cohort where allpatients have recieved treatment with epirubicin monotherapy before surgical removal of alocally advanced breast tumour, and where all patients have beensubjected to objective evaluation of the response to thetherapy. Subsequent to sequencing, we will analyse the data andcompare with the clinical data for each patient (object response totherapy). The main aim being to identify mutations that are associatedwith resistance to epirubicin. Identification of mutations with strongpredictive value, may have a direct impact on cancer treatment sinceit opens the possibility for genetic testing of a tumour, and desicionon which drug is likely to work best, prior to treatment start.

Dataset EGAD00001000264

Genomic Alterations in Gingivo-buccal Cancer: ICGC-India Project_YR01

Dataset EGAD00001000272

Breast Cancer Exome Sequencing

Dataset EGAD00001000110

Mutational landscapes of primary triple negative breast cancers - Exomes

Dataset EGAD00001000113

Mutational landscapes of primary triple negative breast cancers - WGS

Dataset EGAD00001000115

Breast Cancer Whole Genome Sequencing

Dataset EGAD00001000121

HER2 positive Breast Cancer

Dataset EGAD00001000126

Breast Cancer Matched Pair Cell Line Whole Genomes

Dataset EGAD00001000130

Mutational landscapes of primary triple negative breast cancers - RNA seq

Dataset EGAD00001000132

The landscape of cancer genes and mutational processes in breast cancer

Dataset EGAD00001000133

Mutational processes moulding the genomes of 21 breast cancers

The expression data for this study can be found here: http://www.ebi.ac.uk/arrayexpress/experiments/E-MTAB-1088/and its SNP6 data can be found here:http://www.ebi.ac.uk/arrayexpress/experiments/E-MTAB-1087/

Dataset EGAD00001000138

Triple Negative Breast Cancer Whole Genomes

Dataset EGAD00001000141

Lung Cancer Whole Genomes

Dataset EGAD00001000144

Matched Pair Cancer Cell line Whole Genomes

Dataset EGAD00001000145

A Comprehensive Catalogue of Somatic Mutations from a Human Cancer Genome

Dataset EGAD00001000149

Massive genomic rearrangement acquired in a single catastrophic event during cancer development

Dataset EGAD00001000002

CLL cancer Sample Sequencing

Dataset EGAD00001000004

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