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• Results of single-cell sequencing of adipose-derived mesenchymal stromal cells and dermal fibroblasts.

  Adipose-derived mesenchymal stromal cells from subcutaneous (n=4) and visceral (n=4) tissue, along with dermal fibroblasts (n=3) were analyzed by single-cell RNA sequencing.

  Dataset EGAD00001009995

• Transcriptome analysis of CD8 T-cells from blood, fat, liver and skin

  CD8 Tcells were FACS sorted and processed with 10x Genomics Chromium Next GEM SingleCell V(D)J Reagents Kits v1.1 sequencing. In total 6 samples were processed. Fastq files are supplied.

  Dataset EGAD00001010007

• HGSOC organoid sequencing study

  sWGS dataset of 18 matched PDO and ascites samples, and scDNA sequencing of three of these PDOs.

  Dataset EGAD00001010297

• Paired diagnostic and relapse medulloblastoma sequencing

  Paired diagnostic and relapse medulloblastoma sequencing. Targetted panel sequencing (n=8 relapse, n=7 matched diagnostic). Whole exome sequencing (n=23 relapse, n=18 matched diagnostic). Capture using Agilent SureSelect.

  Dataset EGAD00001010321

• HiSeq Colorectal Cancer Dataset

  Set of 19 patients afflicted with colorectal cancer with matching preoperative and postoperative blood plasma, PBMC, and tumor biopsy sequencing data. Originally referenced by Genome-wide cell-free DNA mutational integration enables ultra-sensitive cancer monitoring. Nat Med. 2020, Zviran et. al.

  Dataset EGAD00001011186

• Low-Coverage Whole-Genome Sequencing Data (Tissue and Buffy coat Samples)

  This dataset contains low-coverage whole-genome sequencing (lcWGS) data based on genomic DNA from 8 fresh-frozen prostate cancer tissue samples and matched buffy coat samples from 8 prostate cancer patients.

  Dataset EGAD00001015652

• Methylated DNA Immunoprecipitation Sequencing Data (Tissue and Buffy coat Samples)

  This dataset contains methylated DNA immunoprecipitation sequencing (MeDIP-seq) data based on genomic DNA from 8 fresh-frozen prostate cancer tissue samples and matched buffy coat samples from 8 prostate cancer patients.

  Dataset EGAD00001015653

• an integrated molecular study of clear cell renal cell carcinoma (ccRCC) including whole-genome/exome and RNA sequencing as well as array-based gene expression/copy-number/methylation analyses

  an integrated molecular study of clear cell renal cell carcinoma (ccRCC) including whole-genome/exome and RNA sequencing as well as array-based gene expression/copy-number/methylation analyses

  Study EGAS00001000509

• Multiomic Dissection of Movement and Neurocognitive Toxicity Following BCMA-Targeting CAR T Therapy

  We report a case of parkinsonism following treatment with ciltacabtagene autoleucel. To investigate underlying mechanisms, we performed a multi-pronged longitudinal analysis using single-cell RNA/TCR-sequencing including both cerebrospinal fluid (CSF) and peripheral blood samples, spanning a time frame over 6 month after CAR T cell therapy.

  Study EGAS50000001634

• Transcriptome profiling of HNSCC treated with PD1/PDL1

  Immune checkpoint inhibitors have improved survival in several solid tumors, including head and neck squamous cell carcinoma (HNSCC). However, current use of PD-1/PD-L1 inhibitors relies on PD-L1 expression, which does not reliably predict patient response. Therefore, better predictive biomarkers are needed to identify which patients benefit from immunotherapy. Previous studies suggest that genomic and transcriptomic features may help predict treatment response. This study aims to integrate genomic, transcriptomic, and methylomic data from 31 patients with recurrent/metastatic HNSCC to identify new biomarkers of resistance to anti-PD-1/PD-L1 therapy.

  Dataset EGAD50000002506