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• FMI data

  This dataset contains somatic alteration calls summarized at the gene level for 715 patients profiled by FoundationOne (Foundation Medicine).

  Dataset EGAD00001006616

• Whole-exome sequencing data from head and neck cancer patients

  This dataset contains paired-end whole-exome sequencing data (2x50 bp) from the normal samples, the primary tumors and the recurrences/metastases of 8 head and neck cancer patients.

  Dataset EGAD00001011278

• Transcriptomic Profiles of Neoantigen-Reactive T Cells in Human Gastrointestinal Cancers

  This study explores the transcriptomic profiles of neoantigen-reactive tumor-infiltrating lymphocytes (TILs) from human bile duct and pancreatic cancer. The submitted data are bulk tumor RNA-Seq, tumor and germline whole-exome sequencing from 10 patients, and single cell RNA-Seq data from TIL of 5 of these patients.

  Study phs002765

• Characterization of Immune-Related Gene Expression in Lung Cancer

  We performed a comprehensive analysis of inter- and intratumor heterogeneity of immune gene expression in 160 lung cancer patients from the Environment And Genetics in Lung cancer Etiology (EAGLE) study. The transcriptome was profiled with RNA sequencing in 269 tumor samples and 110 normal tissue samples from 160 subjects.

  Study phs002346

• Dietary convergence induces individual responses in faecal microbiome composition

  This dietary intervention employed an ABA design where participants maintained their habitual diet during baseline and washout periods, while restricting intake to only oats, whole milk, and water during the intervention phase. The study deliberately imposed this severe dietary shift to maximize observable effects on gut microbiome composition and function.

  Study EGAS50000000948

• CXCR4 induces memory formation over exhaustion in CAR-T cells to achieve durable leukemia targeting

  This project focuses on acute myeloid leukemia and the development of chimeric antigen receptor (CAR) T cell therapy. We investigated how enforced expression of the chemokine receptor CXCR4 promotes memory acquisition and long-term persistence of CAR-T cells, thereby enhancing their therapeutic efficacy and durability against leukemia.

  Study JGAS000848

• T-cell receptor repertoire profiling (PBMC)

  This study assessed the TCR repertoire in peripheral blood from patients before, during and after neoadjuvant chemoimmunotherapy. TCR beta chain sequences in RNA from peripheral blood were amplified with the OncomineTM long read assay, templated and sequenced. TCR metrics such as clonality, evenness and diversity were assessed in relation with response metrics.

  Study EGAS50000001137

• T-cell receptor repertoire profiling (FFPE tissue)

  This study assessed the TCR repertoire in tumor tissue from NSCLC patients before, during and after neoadjuvant chemoimmunotherapy. TCR beta chain sequences in RNA from FFPE tissue were amplified with the OncomineTM short read assay, templated and sequenced. TCR metrics such as clonality, evenness and diversity were assessed in relation with response metrics.

  Study EGAS50000001138

• B Cell Receptor Study From Early Breast Cancer Tumour Samples

  B and T cells are key components of the adaptive immune system and play an important role in anti-cancer immunity. In this study, we performed an integrative analysis of the B cell and T cell repertoires across 25 serial breast tumour biopsies from 10 patients during neoadjuvant therapy.

  Study EGAS50000000241

• Analysis_of_resistance_to_PLX4032

  We have collected material from a patient who had BrafV600E mutant melanoma that wastreated with PLX4032. We have germline DNA from the patient and DNA and RNA fromdistinct lesions before and after treatment with PLX4032. We would like to exome sequencethese samples to gain a snap shot of the mechanisms of resistance that are operative.

  Study EGAS00001000415