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• A95632D

  Whole genome sequencing for single cells for library A95632D 644 samples; filetype=bam

  Dataset EGAD00001008222

• H014: HES5 mediates NOTCH signaling by interaction with AKT to drive liver carcinogenesis

  Notch signaling plays a pivotal role in liver development and aberrant Notch signaling may lead to hepatocellular (HCC) or cholangiocellular carcinoma (CCA) development. Using whole exome sequencing of 54 human HCC samples, we discovered 19 somatic missense mutations in 15 different Notch pathway genes affecting 24.6% (14 of 57) of patients. Prediction of functional impact of these Notch pathway mutations revealed HES5-R31G to have high relevance. We found HES5 to be strongly activated by Notch signaling. In vitro, HES5 reduced cell migration and clonogenicity and in vivo, HES5 inhibited MYC-dependent liver tumor formation. But together with AKT, HES5 increased liver tumor formation in a mouse model. HES5 directly binds to AKT and AKT expression leads to increase HES5 protein levels. Furthermore, HES5 exhibits a negative feed-back loop by inhibiting NOTCH1 and HES1 gene expression. In contrast, HES5-R31G appears to be non-functional possibly by loss of nuclear translocation

  Study EGAS00001003329

• Obesity and hyperinsulinemia drive adipocytes to activate a cell cycle program and senesce

  Study EGAS00001005770

• Data Access Commitee of the Kok group, NKI

  Dac EGAC00001003025

• Department of Pediatrics, The University of Tokyo Data Access Committee

  Dac EGAC00001000207

• DAC to control data accession to the Myeloproliferative Neoplasm transcriptome study

  Dac EGAC00001001134

• The University of Hong Kong Intestinal Metaplasia Organoids Study

  Dac EGAC00001003502

• Elucidating the molecular landscape of KRAS/BRAF mutant colorectal cancers

  Study EGAS00001007459

• The admixture histories of Cabo Verde

  Study EGAS00001006348

• Study of the microenvironment of angioimmunoblastic T-cell lymphoma

  Study EGAS00001006401

• Enhancer-gene rewiring in the pathogenesis of Quebec Platelet Disorder

  Study EGAS00001004315

• Genetic Effects on the Skin Methylome in Healthy Older Twins

  Study EGAS00001007816

• CeD_Italy

  Association results from the Italian cohort

  Dataset EGAD00010001771

• CeD_Ireland

  Association results from the Irish cohort

  Dataset EGAD00010001769

• CeD_Netherlands

  Association results from the Dutch cohort

  Dataset EGAD00010001764

• ChIP-seq in KMS11 and TKO cells

  Histone chIP-seq in t(4;14) Myeloma cell line KMS11 and KMS11 cells with knock-out of translocated NSD2 allele (KMS11 TKO).

  Study EGAS50000000077

• Acetalax and bisacodyl triple-negative breast cancer RNA-Seq

  Analysis of gene expression in triple negative breast cancer xenografts exhibiting good or bad response upon acetalax and bisacodyl treament.

  Study EGAS50000000618

• WES of Adenoid Cystic Carcinoma Treated with Axitinib and Avelumab

  To determine potential mutational biomarkers of response to combination axitinib and avelumab, whole exome sequencing was performed on 24 adenoid cystic carcinomas treated with combination axitinib and avelumab with paired normal samples.

  Dataset EGAD50000002467

• DNA methylation and transposable element landscapes in human regulatory and conventional Tcells

  Whole genome bisulfate sequencing using tagmentation of Tcells from skin and blood.The method improved TWGBS protocol (Weichenhan et al.), Methods Mol. Biol. 2018, vol. 1708 pp.105-122) was used

  Dataset EGAD50000001022

• RNA-seq data from iCAF (sorted) and myCAF cluster 0 (spread) CAF-S1 fibroblasts maintained in culture

  RNA-seq data from iCAF (sorted) and myCAF cluster 0 (spread) CAF-S1 fibroblasts maintained in culture

  Study EGAS00001004031

• Detection of human brain cancers using genomic and immune cell characterization of cerebrospinal fluid through CSF-BAM

  Detection of human brain cancers using genomic and immune cell characterization of cerebrospinal fluid through CSF-BAM

  Study EGAS00001008199

• mFAST-SeqS of plasma-DNA

  Sequence data from L1-amplicon libraries prepared from plasma-DNA from a set of 24 female controls and 18 male controls without malignant disease and samples from patients breast (n= 28) and prostate cancer patients (n=61).

  Dataset EGAD00001001314

• RNA-seq analysis of megakaryocytes and granulocytes in Quebec platelet disorder

  RNA-seq was performed on cultured megakaryocytes and peripheral-blood derived granulocytes from individuals with QPD and a unaffected controls. Each group consisted of n=3 biological replicates.

  Dataset EGAD00001006053

• 16 Year Life History and Genomic Evolution of an ER+ HER2- Breast Cancer

  Case report of an ER+ Her2- breast cancer patient. Whole exome and transcriptome sequencing at time of diagnosis and relapse, targeted DNA sequencing of a liver met

  Dataset EGAD00001006365

• Dataset of whole-exome sequencing of clonally related neuroblastoma and teratoma

  This dataset includes bam files of WES of clonally related neuroblastoma and teratoma as well as peripheral blood samples as a control. Neuroblastoma and teratoma samples were formalin-fixed paraffin embedded.

  Dataset EGAD00001007039