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• Comparison of 3 protocols for deriving pancreatic progenitors from hPSCs (RNA-seq)

  This dataset contains 26 mapped bam files. The samples were generated with 3 different protocols for deriving pancreatic progenitors from hPSC. Three parallel differentiations were performed, all done in a hPSC NKX6.1-GFP reporter line. For each protocol there are three cellular populations: total (presort), GFP+ and GFP- . In summary: 3 differentiations x 3 protocols x 3 cellular populations. We prepared Smart-Seq2 RNA-seq libraries for the 27 samples, 1 sample failed library preparation and is not therefore included in this dataset.

  Dataset EGAD00001004823

• Characterization of chromatin accessibility in metastatic prostate cancer

  The development of resistance to second-generation AR-signaling inhibitors (ARSIs) and progression to metastatic castrate-resistant prostate cancer (mCRPC) represents a huge obstacle to the improvement of patients’ clinical outcomes. Lineage plasticity is a common mechanism that drives the development of mCRPC by changing chromatin conformation at regulatory elements affecting downstream gene activity. ATAC-seq is a popular technique that measures accessible chromatin regions. To better understand of potential epigenomic mechanisms of ARSI resistance in prostate cancer, in this study, we performed ATAC-seq on 70 mCRPC tissue biopsies from the SU2C/PCF West Coast Dream Team (WCDT) cohort.

  Study EGAS00001006698

• HNO Team Data Access Committee

  Dac EGAC00001002801

• Cancer Team Data Access Committee

  Dac EGAC00001002762

• Predictive Oncology Team Data Access Committee

  Dac EGAC00001000995

• Probiotic Study Team Data Access Committee

  Dac EGAC00001001168

• Brain microbiome team data access committee

  Dac EGAC00001001787

• West Coast Dream Team DAC

  Dac EGAC00001002494

• Laboratory of Applied Cancer Genomics team

  Dac EGAC00001002508

• Laboratory of Applied Cancer Genomics team

  Dac EGAC00001002520