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• Constructing database of magnetic resonance imaging of the brain and the ancillary clinical information for multisite collaboration studies: a dataset from Bipolar disorder individuals

  Previously there was no neuroimaging database available for research community that incorporated a large Japanese sample of healthy people and patients with neuropsychiatric disorders. Establishing such a database will enable large-scale, neuroimaging-based investigations on pathophysiology of neuropsychiatric disorders by simply using the large data pool or by combining it with investigators' own data sets.

  Study JGAS000045

• Constructing database of magnetic resonance imaging of the brain and the ancillary clinical information for multisite collaboration studies: a dataset from Depression individuals

  Previously there was no neuroimaging database available for research community that incorporated a large Japanese sample of healthy people and patients with neuropsychiatric disorders. Establishing such a database will enable large-scale, neuroimaging-based investigations on pathophysiology of neuropsychiatric disorders by simply using the large data pool or by combining it with investigators' own data sets.

  Study JGAS000044

• GSA bigbatch raw data

  Unfiltered genotype data for a larger batch (Batch 2) of 8,697 DDD Study participants (and 1 "Blank" sample). Samples include 2,858 mothers, 2,857 fathers and 2,982 probands, and form 2,918 trios. Most of the probands have been previously genoyped on the llumina HumanCoreExome BeadChip (EGAD00010001598) or the Illumina InfiniumCoreExome Beadchip (EGAD00010001600). All samples were genotyped on the Illumina Global Screening Array.

  Dataset EGAD00010002569

• Subclonal evolution of four ER+ breast cancers determined by WGS and scRNA-Seq

  We analyzed the subclonal evolution of four ER+ breast cancers over 2-15 years using whole-genome sequencing (WGS) and single-cell RNA-Seq (scRNA-Seq). For each patient we analyzed 2-6 cancer samples, generally metastatic pleural effusions or ascites, by WGS, along with germline DNA. Two of the samples per patient were selected for single-cell RNA-Seq.

  Study EGAS00001002436

• Genome_Diversity_in_Africa_Project___GemCode_libraries_

  High depth whole genome sequencing from GemCode (10x Genomics) DNA libraries containing long range linkage information for one Baganda trio and one Baganda child (parent already sequenced at high depth). This data is part of a pre-publication release. For information on the proper use of pre-publication data shared by the Wellcome Trust Sanger Institute (including details of any publication moratoria), please see http://www.sanger.ac.uk/datasharing/

  Study EGAS00001001828

• Normal brain controls for ICGC PedBrain DNA methylation sequencing

  DNA methylation profiling of 8 control samples from adult (4) and fetal brain (4) used, for example, for the following studies: Mack, Witt, et al. Epigenomic alterations define lethal CIMP-positive ependymomas of infancy. Nature 506(7489):445-450, 2014 (see EGAS00001000443) Hovestadt, et al. Decoding the regulatory landscape of medulloblastoma using DNA methylation sequencing. 510(7506):537-541, 2014 (see EGAS00001000561)

  Study EGAS00001000909

• Mutation analysis of core biopsies from localized breast cancer patients

  Targeted next-generation sequencing (NGS) of 93 frequently mutated genes in breast cancer using the QIAseq Human Breast Cancer Targeted Panel (QIAGEN), which uses digital sequencing by incorporating unique molecular barcodes (UMI).

  Dataset EGAD00001008396

• Single-cell somatic copy number variants in brain using different amplification methods and reference genomes

  Low coverage paired end Illumina WGS from cells amplified with Picoplex, PTA, and droplet MDA. Two brains with Multiple System, Atrophy, one control, and non-brain controls (fibroblasts, NA12878)

  Study EGAS50000000020

• RNU2-2 splicing signature RNA-Seq

  This dataset is composed of RNA-Seq samples: 49 controls which are probands without snRNA rare variants and 19 affected probands with either monoallelic or biallelic variants in RNU2-2. RNA was extracted from short-term lymphocytes cultures. RNA-Seq libraries were obtained by hybrid capture of fragmented cDNA with RNA probes from exome v8 (Agilent)

  Dataset EGAD50000002045

• Targeting Heterochromatin Eliminates Malignant Stem Cells in Chronic Myelomonocytic Leukemia Through Reactivation of Retroelements and Innate Immune pathways

  RNA-sequencing, ATAC-sequencing, CUT&Tag-sequencing, data from CMML patient and aged-matched healthy donor CD34+ cells. RNA-sequencing data from patient CD34+ cells after treatment for 4 days with decitabine or UNC0638 inhibitors, alone or together, or left untreated

  Dataset EGAD50000000542