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Comparing sequencing of four proto-typical Burkitt lymphomas (BL) with IG-MYC translocation.
By whole-genome, exome, transcriptome and methylome sequencing of four proto-typical Burkitt lymphomas (BL) with IG-MYC translocation we identified seven recurrently mutated genes including ID3. In an extended cohort, 36/53 (68%) molecularly-defined BL carried potentially damaging mutations of ID3 which were enriched at somatic hypermutation motifs. Only 6/47 (13%) other IG-MYC-positive B-cell lymphomas carried ID3 mutations suggesting cooperation of ID3 inactivation and IG-MYC translocation to be a hallmark of Burkitt lymphomagenesis.
- Type: Whole Genome Sequencing
- Archiver: European Genome-phenome Archive (EGA)
Click on a Dataset ID in the table below to learn more, and to find out who to contact about access to these data
| Dataset ID | Description | Technology | Samples |
|---|---|---|---|
| EGAD00001000176 | Illumina Genome Analyzer IIx Illumina HiSeq 2000 | 8 | |
| EGAD00001000274 | Illumina HiSeq 2000 | 4 | |
| EGAD00001000355 | Illumina HiSeq 2000 | 46 | |
| EGAD00001000356 | Illumina HiSeq 2000 | 23 | |
| EGAD00010000427 | HumanMethylation450k Bead Chip - Genome Studio | 4 | |
| EGAD00010000429 | HumanMethylation450k Bead Chip - Genome Studio | 4 |
| Publications | Citations |
|---|---|
|
Integrative whole-genome sequence analysis reveals roles of regulatory mutations in BCL6 and BCL2 in follicular lymphoma.
Sci Rep 7: 2017 7040 |
20 |
|
Integrating whole genome sequencing, methylation, gene expression, topological associated domain information in regulatory mutation prediction: A study of follicular lymphoma.
Comput Struct Biotechnol J 20: 2022 1726-1742 |
6 |