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Genentech Small Cell Lung Cancer (SCLC) Screen

Exome capture, RNA-Seq, whole genome sequencing of set of Small Cell Lung Cancer samples.

Click on a Dataset ID in the table below to learn more, and to find out who to contact about access to these data

Dataset ID Description Technology Samples
EGAD00001000221 Illumina HiSeq 2000 4
EGAD00001000222 Illumina HiSeq 2000 103
EGAD00001000223 Illumina HiSeq 2000 79
EGAD00010000276 Illumina_2.5M 56
EGAD00010000278 Illumina_2.5M 51
Publications Citations
Comprehensive genomic analysis identifies SOX2 as a frequently amplified gene in small-cell lung cancer.
Nat Genet 44: 2012 1111-1116
DNA methylation in small cell lung cancer defines distinct disease subtypes and correlates with high expression of EZH2.
Oncogene 34: 2015 5869-5878
Automated identification of reference genes based on RNA-seq data.
Biomed Eng Online 16: 2017 65
Significantly mutated genes and regulatory pathways in SCLC-a meta-analysis.
Cancer Genet 216-217: 2017 20-28
Targeting CREB Pathway Suppresses Small Cell Lung Cancer.
Mol Cancer Res 16: 2018 825-832
MYC paralog-dependent apoptotic priming orchestrates a spectrum of vulnerabilities in small cell lung cancer.
Nat Commun 10: 2019 3485
Transposable element expression in tumors is associated with immune infiltration and increased antigenicity.
Nat Commun 10: 2019 5228
Biomarker potential of repetitive-element transcriptome in lung cancer.
PeerJ 7: 2019 e8277
ASCL1-regulated DARPP-32 and t-DARPP stimulate small cell lung cancer growth and neuroendocrine tumour cell proliferation.
Br J Cancer 123: 2020 819-832
Ferroptosis response segregates small cell lung cancer (SCLC) neuroendocrine subtypes.
Nat Commun 12: 2021 2048
Therapeutic targeting of ATR yields durable regressions in small cell lung cancers with high replication stress.
Cancer Cell 39: 2021 566-579.e7
A GPC2 antibody-drug conjugate is efficacious against neuroblastoma and small-cell lung cancer via binding a conformational epitope.
Cell Rep Med 2: 2021 100344
ISOTOPE: ISOform-guided prediction of epiTOPEs in cancer.
PLoS Comput Biol 17: 2021 e1009411
Identification of TAZ as the essential molecular switch in orchestrating SCLC phenotypic transition and metastasis.
Natl Sci Rev 9: 2022 nwab232
Expression of down-regulated ERV LTR elements associates with immune activation in human small-cell lung cancers.
Mob DNA 14: 2023 2
Immunogenomic Landscape of Neuroendocrine Prostate Cancer.
Clin Cancer Res 29: 2023 2933-2943