Genome-wide mutation analysis of germinal-center B-cell derived lymphomas within the ICGC MMML-Seq Consortium
Germinal-center B-cell derived lymphomas (GCB-lymphomas) are the most common B-cell lymphomas in children and adults, with Burkitt Lymphomas (BL) predominating in childhood and follicular lymphoma (FL) and diffuse large B-cell lymphomas (DLBCL) predominating in older age groups. The cell-of-origin in all these lymphomas is supposed to be a germinal center B-cell and transformation of FL in DLBCL or intermediate DLBCL/BL (intL) can occur. In the framework of the German ICGC MMML-Seq we are currently exploring sequencing data of GCB-lymphomas and paired normal controls as well as normal B-cell subsets separated by FACS. This includes whole genome, transcriptome, miRNAome and whole methylome datasets.
- Type: Other
- Archiver: EGA European Genome-Phenome Archive
Click on a Dataset ID in the table below to learn more, and to find out who to contact about access to these data
|EGAD00001000278||Illumina HiSeq 2000||12|
|EGAD00001000279||Illumina Genome Analyzer IIx||4|
|EGAD00001000281||Illumina HiSeq 2000||6|
|EGAD00001000355||Illumina HiSeq 2000||46|
|EGAD00001000356||Illumina HiSeq 2000||23|
|EGAD00010000377||HumanMethylation450k Bead Chip - Genome Studio||6|
|EGAD00010000379||HumanMethylation450k Bead Chip - Genome Studio||2|
Hypermutation of the inactive X chromosome is a frequent event in cancer.
Cell 155: 2013 567-581
Integrative whole-genome sequence analysis reveals roles of regulatory mutations in BCL6 and BCL2 in follicular lymphoma.
Sci Rep 7: 2017 7040
Integrating whole genome sequencing, methylation, gene expression, topological associated domain information in regulatory mutation prediction: A study of follicular lymphoma.
Comput Struct Biotechnol J 20: 2022 1726-1742