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Genome-wide mutation analysis of germinal-center B-cell derived lymphomas within the ICGC MMML-Seq Consortium

Germinal-center B-cell derived lymphomas (GCB-lymphomas) are the most common B-cell lymphomas in children and adults, with Burkitt Lymphomas (BL) predominating in childhood and follicular lymphoma (FL) and diffuse large B-cell lymphomas (DLBCL) predominating in older age groups. The cell-of-origin in all these lymphomas is supposed to be a germinal center B-cell and transformation of FL in DLBCL or intermediate DLBCL/BL (intL) can occur. In the framework of the German ICGC MMML-Seq we are currently exploring sequencing data of GCB-lymphomas and paired normal controls as well as normal B-cell subsets separated by FACS. This includes whole genome, transcriptome, miRNAome and whole methylome datasets.

Click on a Dataset ID in the table below to learn more, and to find out who to contact about access to these data

Dataset ID Description Technology Samples
EGAD00001000278 Illumina HiSeq 2000 12
EGAD00001000279 Illumina Genome Analyzer IIx 4
EGAD00001000281 Illumina HiSeq 2000 6
EGAD00001000355 Illumina HiSeq 2000 46
EGAD00001000356 Illumina HiSeq 2000 23
EGAD00001000645 42
EGAD00001000648 31
EGAD00001000650 52
EGAD00001001619 43
EGAD00010000377 HumanMethylation450k Bead Chip - Genome Studio 6
EGAD00010000379 HumanMethylation450k Bead Chip - Genome Studio 2
Publications Citations
Hypermutation of the inactive X chromosome is a frequent event in cancer.
Cell 155: 2013 567-581
44
Integrative whole-genome sequence analysis reveals roles of regulatory mutations in BCL6 and BCL2 in follicular lymphoma.
Sci Rep 7: 2017 7040
14
Integrating whole genome sequencing, methylation, gene expression, topological associated domain information in regulatory mutation prediction: A study of follicular lymphoma.
Comput Struct Biotechnol J 20: 2022 1726-1742
2