Study

The mission of the BIOS Consortium is to create a large-scale data infrastructure and to bring together BBMRI researchers focusing on integrative omics studies in Dutch Biobanks.

Study ID Alternative Stable ID Type
EGAS00001001077 Other

Study Description

The advent of the genome-wide association study (GWAS) led to the successful identification of thousands of variants that are robustly associated with complex disease phenotypes. Dutch biobanks played a substantial role in these discoveries. For most of these variants, however, the mechanisms through which they contribute to these phenotypes remain unknown. The BIOS Consortium applies a functional genomics approach that integrates genome-wide genetic data with data on the epigenome and transcriptome to elucidate these mechanisms. Over 4000 samples from BBMRI-NL biobanks with in-depth information on disease phenotypes and GWAS data are being enriched with RNA-sequencing and genome-wide DNA methylation data. The same is true for samples with whole-genome sequencing data from GoNL. This unique data infrastructure provides a powerful platform to evaluate key questions in integrative omics from establishing comprehensive eQTL and meQTL catalogues to linking molecular pathways across omics levels to phenotypic outcomes.

Study Datasets 12 datasets.

Click on a Dataset ID in the table below to learn more, and to find out who to contact about access to these data

Dataset ID Description Technology Samples
EGAD00001001622
BBMRI - BIOS project - Freeze 1 - Fastq files
Illumina HiSeq 2000 2199
EGAD00001001623
BBMRI - BIOS project - Freeze 1 - Bam files
2117
EGAD00001003757
BBMRI - BIOS project - Freeze 2 - Fastq files
Illumina HiSeq 2000 3686
EGAD00001003758
BBMRI - BIOS project - Freeze 2 - Bam files
Illumina HiSeq 2000 3686
EGAD00001003784
BBMRI - BIOS project - Freeze 2 - Bam files - unrelated samples
Illumina HiSeq 2000 3559
EGAD00001003785
BBMRI - BIOS project - Freeze 2 - Fastq files - unrelated samples
Illumina HiSeq 2000 3559
EGAD00001003786
BBMRI - BIOS project - Freeze 2 - Bam files - GoNL samples
Illumina HiSeq 2000 420
EGAD00001003787
BBMRI - BIOS project - Freeze 2 - Fastq files - GoNL samples
Illumina HiSeq 2000 420
EGAD00001003937
BBMRI - BIOS project - Freeze 2 - Bam files - Imprinting analysis
Illumina HiSeq 2000 131
EGAD00010000887
Freeze 1 of the RP3 project
Illumina Human Methylation 450k BeadChip 3898
EGAD00010001416
BBMRI - BIOS project - Freeze 2 - methylation
Illumina Human Methylation 450k BeadChip 4386
EGAD00010001420
Read counts determined using HTSeq-count for the BBMRI BIOS Freeze 2 RNAseq data
RNAseq 3560

Who archives the data?

Publications

Citations

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