Study
The mission of the BIOS Consortium is to create a large-scale data infrastructure and to bring together BBMRI researchers focusing on integrative omics studies in Dutch Biobanks.
| Study ID | Alternative Stable ID | Type |
|---|---|---|
| EGAS00001001077 | Other |
Study Description
The advent of the genome-wide association study (GWAS) led to the successful identification of thousands of variants that are robustly associated with complex disease phenotypes. Dutch biobanks played a substantial role in these discoveries. For most of these variants, however, the mechanisms through which they contribute to these phenotypes remain unknown. The BIOS Consortium applies a functional genomics approach that integrates genome-wide genetic data with data on the epigenome and transcriptome to elucidate these mechanisms. Over 4000 samples from BBMRI-NL biobanks with in-depth information on disease phenotypes and GWAS data are being enriched with RNA-sequencing and genome-wide DNA methylation data. The same is true for samples with whole-genome sequencing data from GoNL. This unique data infrastructure provides a powerful platform to evaluate key questions in integrative omics from establishing comprehensive eQTL and meQTL catalogues to linking molecular pathways across omics levels to phenotypic outcomes.
Study Datasets 12 datasets.
Click on a Dataset ID in the table below to learn more, and to find out who to contact about access to these data
| Dataset ID | Description | Technology | Samples |
|---|---|---|---|
| EGAD00001001622 |
BBMRI - BIOS project - Freeze 1 - Fastq files
|
Illumina HiSeq 2000 | 2199 |
| EGAD00001001623 |
BBMRI - BIOS project - Freeze 1 - Bam files
|
2117 | |
| EGAD00001003757 |
BBMRI - BIOS project - Freeze 2 - Fastq files
|
Illumina HiSeq 2000 | 3686 |
| EGAD00001003758 |
BBMRI - BIOS project - Freeze 2 - Bam files
|
Illumina HiSeq 2000 | 3686 |
| EGAD00001003784 |
BBMRI - BIOS project - Freeze 2 - Bam files - unrelated samples
|
Illumina HiSeq 2000 | 3559 |
| EGAD00001003785 |
BBMRI - BIOS project - Freeze 2 - Fastq files - unrelated samples
|
Illumina HiSeq 2000 | 3559 |
| EGAD00001003786 |
BBMRI - BIOS project - Freeze 2 - Bam files - GoNL samples
|
Illumina HiSeq 2000 | 420 |
| EGAD00001003787 |
BBMRI - BIOS project - Freeze 2 - Fastq files - GoNL samples
|
Illumina HiSeq 2000 | 420 |
| EGAD00001003937 |
BBMRI - BIOS project - Freeze 2 - Bam files - Imprinting analysis
|
Illumina HiSeq 2000 | 131 |
| EGAD00010000887 |
Freeze 1 of the RP3 project
|
Illumina Human Methylation 450k BeadChip | 3898 |
| EGAD00010001416 |
BBMRI - BIOS project - Freeze 2 - methylation
|
Illumina Human Methylation 450k BeadChip | 4386 |
| EGAD00010001420 |
Read counts determined using HTSeq-count for the BBMRI BIOS Freeze 2 RNAseq data
|
RNAseq | 3560 |
Who archives the data?
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