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Analysis of mutational signatures caused by exposure to known mutagens in human induced pluripotent stem (iPS) cells. A reference human iPS cell-line will be exposed to 100 chemicals known or proposed to be mutagenic. Following exposure to mutagen, cells will undergo a period of recovery before sub clones are generated and sequenced. The progenitor “parental” IPS cell-line will be used to generate reference sequence data, in order to determine the mutational signatures acquired as a result of exposure to different mutagens.

Click on a Dataset ID in the table below to learn more, and to find out who to contact about access to these data

Dataset ID Description Technology Samples
EGAD00001004583 HiSeq X Ten 324
EGAD00001005351 HiSeq X Ten 6
Publications Citations
A Compendium of Mutational Signatures of Environmental Agents.
Cell 177: 2019 821-836.e16
Mapping clustered mutations in cancer reveals APOBEC3 mutagenesis of ecDNA.
Nature 602: 2022 510-517