Analysis of mutational signatures caused by exposure to known mutagens in human induced pluripotent stem (iPS) cells. A reference human iPS cell-line will be exposed to 100 chemicals known or proposed to be mutagenic. Following exposure to mutagen, cells will undergo a period of recovery before sub clones are generated and sequenced. The progenitor “parental” IPS cell-line will be used to generate reference sequence data, in order to determine the mutational signatures acquired as a result of exposure to different mutagens.
- Type: Whole Genome Sequencing
- Archiver: EGA European Genome-Phenome Archive
Click on a Dataset ID in the table below to learn more, and to find out who to contact about access to these data
|EGAD00001004583||HiSeq X Ten||324|
|EGAD00001005351||HiSeq X Ten||6|
A Compendium of Mutational Signatures of Environmental Agents.
Cell 177: 2019 821-836.e16
Mapping clustered mutations in cancer reveals APOBEC3 mutagenesis of ecDNA.
Nature 602: 2022 510-517