We will use whole genome sequencing to examine normal appearing oesophageal epithelium and skin to determine the mutational burden. DNA will be extracted from epithelia of a defined size and we will overlay positional information from the epithelial pieces to give clone maps over a wide area. This will be done in both oesophageal epithelium and skin
- Type: Cancer Genomics
- Archiver: EGA European Genome-Phenome Archive
Click on a Dataset ID in the table below to learn more, and to find out who to contact about access to these data
|EGAD00001004159||HiSeq X Ten||25|
|EGAD00001006194||HiSeq X Ten Illumina HiSeq 2500 Illumina NovaSeq 6000||805|
Somatic mutant clones colonize the human esophagus with age.
Science 362: 2018 911-917
Measuring the distribution of fitness effects in somatic evolution by combining clonal dynamics with dN/dS ratios.
Elife 9: 2020 e48714
Selection of Oncogenic Mutant Clones in Normal Human Skin Varies with Body Site.
Cancer Discov 11: 2021 340-361