WGS Mutant clone mapping in normal oesohagus and skin
|Study ID||Alternative Stable ID||Type|
Study Datasets 1 dataset.
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The extent to which cells in normal tissues accumulate mutations during life is poorly understood. Some mutant cells expand into clones that can be detected by genome sequencing. We mapped mutant clones in normal esophageal epithelium from nine donors aged 20-75. Somatic mutations accumulate with age and are mainly caused by intrinsic mutational processes. We found strong Darwinian selection of clones carrying mutations in 14 cancer genes, with tens to hundreds of such clones per square ... (Show More)
|HiSeq X Ten||25|