Therapeutic Targeting of Ependymoma as Informed by Oncogenic Enhancer Profiling
Genomic sequencing has driven precision-based oncology therapy; however, genetic drivers remain unknown or non-targetable for many malignancies, demanding alternative approaches to identify therapeutic leads. Ependymomas are chemotherapy-resistant brain tumours, which, despite genomic sequencing, lack effective molecular targets. Here, we mapped active chromatin landscapes in 42 primary ependymomas in two non-overlapping primary ependymoma cohorts. Enhancer regions revealed novel oncogenes, molecular targets, and pathways, which when subjected to small molecule inhibitor or shRNA treatment, increased survival and slowed proliferation in mouse and neurosphere patient-derived models of ependymomas. This study represents one of the largest enhancer mapping study of any cancer type to date, and provides a framework for target and drug discovery for other cancers recalcitrant to therapeutic development because of their lack of known genetic drivers.
- Type: Other
- Archiver: EGA European Genome-Phenome Archive
Click on a Dataset ID in the table below to learn more, and to find out who to contact about access to these data
|EGAD00001003940||Illumina HiSeq 2000||48|
|EGAD00001003966||Illumina HiSeq 2000||24|
|EGAD00001003973||Illumina HiSeq 2000||-|
|EGAD00001003979||Illumina HiSeq 2000||-|
|EGAD00001008801||Illumina NovaSeq 6000||14|
|EGAD00001008805||Illumina HiSeq 2000||1|
|EGAD00001008806||Illumina HiSeq 2000||1|
Therapeutic targeting of ependymoma as informed by oncogenic enhancer profiling.
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