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Whole genome and whole transcriptome sequencing of patients diagnosed with angiosarcoma.

Angiosarcomas are rare, clinically-aggressive tumors with a predilection for the elderly and immunosuppressed, which has incited suspicion of an oncogenic virus. We studied the metagenomic landscape of angiosarcomas and identified reads mapping to human herpesvirus-7 (HHV-7). Overall, HHV-7 was present in two-thirds of angiosarcomas, particularly in cases with low tumor mutation burden and lacking signatures of ultraviolet-induced DNA damage. Transcriptomic profiling revealed the enrichment of tumor inflammation signatures in HHV7-positive angiosarcomas. In conclusion, we identified a distinct “inflammatory” subtype of angiosarcoma associated with HHV-7.

Click on a Dataset ID in the table below to learn more, and to find out who to contact about access to these data

Dataset ID Description Technology Samples
EGAD00001005366 HiSeq X Ten Illumina HiSeq 2000 31
EGAD00001005367 Illumina HiSeq 2500 18
Publications Citations
Multiomic analysis and immunoprofiling reveal distinct subtypes of human angiosarcoma.
J Clin Invest 130: 2020 5833-5846
36
Spatial transcriptomics reveal topological immune landscapes of Asian head and neck angiosarcoma.
Commun Biol 6: 2023 461
1