Study

Alternative lengthening of telomeres in childhood neuroblastoma from genome to proteome

Study ID Alternative Stable ID Type
EGAS00001004349 Other

Study Description

Telomere maintenance by telomerase activation or alternative lengthening of telomeres (ALT) is a major determinant of poor outcome in neuroblastoma. Here, we screen for ALT in primary and relapsed neuroblastomas and characterize its features using multi-omics profiling. We aim to deepen the knowledge about the biology and clinical features of ALT-positive neuroblastomas by enriching ALT tumors in the study cohort independent of ATRX mutation status. Using a combination of genomic, transcriptomic and proteomic profiling, we provide evidence that this subgroup is clinically and molecularly distinct.

Study Datasets 9 datasets.

Click on a Dataset ID in the table below to learn more, and to find out who to contact about access to these data

Dataset ID Description Technology Samples
EGAD00001006587
94 sample with multi-omics analysis of ALT-positive neuroblastoma tumors, rna sequencing
HiSeq X Ten,Illumina HiSeq 2000,Illumina HiSeq 2500,Illumina HiSeq 4000 715
EGAD00001006625
144 sample from individuals with ALT-positive neuroblastoma tumors, chip-seq sequencing
Illumina HiSeq 2000,Illumina HiSeq 2500 144
EGAD00001006626
238 samples from individuals with ALT-positive neuroblastoma tumors, high coverage whole genome sequencing
HiSeq X Ten,Illumina HiSeq 2000,Illumina HiSeq 2500 238
EGAD00001006637
89 samples of individuals with ALT-positive neuroblastoma tumors, exome sequencing
Illumina HiSeq 2500,Illumina HiSeq 4000 89
EGAD00001006638
97 samples of individuals with ALT-positive neuroblastoma tumors, low coverage whole genome sequencing
Illumina HiSeq 2500,Illumina HiSeq 4000 97
EGAD00001006639
63 samples of individuals with ALT-positive neuroblastoma tumors, high coverage whole genome sequencing
HiSeq X Ten 63
EGAD00001006737
Proteome data of neuroblastoma patients
34
EGAD00001006739
NA
HiSeq X Ten 17
EGAD00001006785
NA
Illumina HiSeq 4000 9

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