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Multi-region whole-exome sequencing of 10 neuroblastoma cases

To investigate intratumour heterogeneity and to better understand tumour evolution in neuroblastoma, we have performed a multi-region whole-exome sequencing on a total of 51 spatially separated tumor samples from 9 primary neuroblastomas (2 low-risk, 1 intermediate-risk and 6 high-risk) and 1 relapsed neuroblastoma. We also assessed the impact of chemotherapy on the clonal expansion by sequencing tumour regions from one medium risk and one high-risk tumour for which we had matched samples obtained at diagnosis and after chemotherapy.

Click on a Dataset ID in the table below to learn more, and to find out who to contact about access to these data

Dataset ID Description Technology Samples
EGAD00001008020 Illumina HiSeq 4000 61
EGAD00001008133 Illumina HiSeq 4000 50
EGAD00001008156 Illumina HiSeq 4000 141
EGAD00010002225 Cytoscan HD 3
Publications Citations
Spatial and temporal intratumour heterogeneity has potential consequences for single biopsy-based neuroblastoma treatment decisions.
Nat Commun 12: 2021 6804