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Whole genome sequencing data of paediatric ETV6::RUNX1 acute lymphoblastic leukemia

ETV6::RUNX1 (E::R) subgroup is the second most frequent form of B cell acute lymphoblastic leukemia (B-ALL) in childhood. This subgroup of ALL generally presents with low-risk features and responds well to chemotherapy with ensuing favorable prognosis. Some patients, however, have a slow response to induction treatment and carry increased risk for relapse.

Type: Whole Genome Sequencing
Archiver: European Genome-phenome Archive (EGA)

3 Datasets

Click on a Dataset ID in the table below to learn more, and to find out who to contact about access to these data

Dataset ID	Description	Technology	Samples
EGAD50000002285	The dataset includes FASTQ and BAM/CRAM files from diagnostic and matched remission (control) samples of five ETV6::RUNX1 ALL patients (ALLT-380, ALLK-114, ALLT-388, ALLT-392, ALLT-394). Sequencing libraries were made using PCR free-based WGS library preparation (PCR-), using NEBNext® Ultra™ II DNA Library Prep Kit (Cat No. E7645). Both diagnostic (90x) and remission (30x) samples were sequenced using Illumina NovaSeq 6000.	Illumina NovaSeq 6000	10
EGAD50000002286	The dataset includes FASTQ and CRAM files from second relapse and matched remission (control) samples of one ETV6::RUNX1 ALL patient (ALLK-104). Sequencing libraries were made using using NEBNext® Ultra™ II DNA Library Prep Kit (Cat No. E7645). Both second relapse (90x) and remission (30x) samples were sequenced using Illumina NovaSeq 6000.	Illumina NovaSeq 6000	2
EGAD50000002287	The dataset includes FASTQ and CRAM files from diagnostic and matched remission (control) samples of two ETV6::RUNX1 ALL patients (ALLT-397, ALLK-132). Sequencing libraries were made using PCR free-based WGS library preparation (PCR-), using Novogene NGS DNA Library Prep Set (Cat No. PT004). Both diagnostic (90x) and remission (30x) samples were sequenced using Illumina NovaSeqX Plus.	Illumina NovaSeq X Plus	4