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Frequency and prognostic significance of genetic abnormalities in a subgroup of intermediate risk neuroblastoma patients: A SIOPEN study

Intermediate risk neuroblastoma includes a rare subgroup of patients over the age of 18 months at diagnosis with unresectable, localised tumours with unfavourable histology without MYCN amplification. This group is treated differently around the world with some patients receiving upfront myeloablative therapy (MAT) in addition to standard treatment with chemotherapy, surgery, radiotherapy and 13 cis retinoic acid, but the overall 5-year patient survival with or without MAT is similar (75%). This study aimed to understand the neuroblastoma biology of this rare patient subgroup.

Type: Cancer Genomics
Archive: European Genome-phenome Archive (EGA)

2 Datasets

Click on a Dataset ID in the table below to learn more, and to find out who to contact about access to these data

Dataset ID	Description	Technology	Samples
EGAD50000002773	Targeted next-generation sequencing data for a SIOPEN intermediate-risk neuroblastoma subgroup (age >18 months, localised, unresectable, non-MYCN-amplified neuroblastoma with unfavourable histology), with a total of 31 cases analysed. All but one sample have been analysed using the same workflow, with the exception being NB32. VCF files for the analyses are included in this dataset.	NextSeq 550	31
EGAD50000002774	Whole exome sequencing (WES) data analysed for the SIOPEN intermediate-risk neuroblastoma subgroup (age >18 months, localised, unresectable, non-MYCN amplified neuroblastoma with unfavourable histology), data for a total of 30 cases available. Four samples were analysed as part of another relapse neuroblastoma study (NB02 to NB05), of which two have germline comparison available. The remaining 26 cases had a different analysis workflow, with all but one having germline comparison available. VCF files from WES analyses are included in this dataset.	NextSeq 550	57