Dataset
Germline and somatic variants in myelodysplastic syndrome and therapy-related myeloid neoplasms
| Dataset ID | Technology | Samples |
|---|---|---|
| EGAD00001004861 | Illumina HiSeq 2000,NextSeq 500 | 396 |
Dataset Description
Somatic mutation frequencies in patients with therapy-related myeloid neoplasms (129 patients, 181 samples including bone marrow, mesenchymal stromal cells and hair DNA) and primary myelodysplastic syndrome (108 patients, 215 samples including bone marrow, mesenchymal stromal cells and hair DNA) is assessed by deep sequencing of selected genes, using a Fluidigm Access Array, a Nimblegen capture panel and an Ion AmpliSeq panel. The dataset consists of paired fastq files obtained by either Hiseq (2x101bp) or Nextseq (2x150bp) Illumina sequencing. The mutational burden is found to be similar in both, however the distribution of variants is different. Correlation of the mutational spectrum with prognosis is also observed.
Data Use Conditions
HMB US PS
See further information on Data Use Conditions
| Label | Code | Version | Modifier |
|---|---|---|---|
| health or medical or biomedical research | DUO:0000006 | 2019-01-07 | |
| user specific restriction | DUO:0000026 | 2019-01-07 | |
| project specific restriction | DUO:0000027 | 2019-01-07 |
