Panel-based NGS data for ADME genes in human liver samples
Panel-based next-generation sequencing data of 150 human surgical liver samples from Caucasian donors. The panel was designed for 340 ADME (absorption, distribution, metabolism and excretion) and ADME-related genes. NGS was carried out on the Illumina HiSeq2500 system (Illumina Inc., San Diego, CA, United States) at high depth with 2 × 100 bps paired-end reads. Variants were called using samtools and varscan (2.3.5). Data on n=15,727 filtered variants for the 150 patients are comprised in one vcf file.
- 150 samples
- DAC: EGAC00001001214
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The IKP-LIVER-NGS Study Group anticipates that data generated from the project will be used by others, such as required in understanding liver pathophysiology, or in guiding selection of markers to map candidate genes involved in disease susceptibility, progression and therapeutic response. Authors who use data from the project must acknowledge the IKP-LIVER-NGS Study Group using the following wording "This study makes use of data generated by the IKP-LIVER-NGS Study Group. Funding for the project was provided in part by the Robert Bosch Stiftung, Stuttgart, Germany" and cite the relevant primary IKP-LIVER-NGS Study Group publication: Klein K, Tremmel R, Winter S, Fehr S, Battke F, Scheurenbrand T, Schaeffeler E, Biskup S, Schwab M, Zanger UM: A New Panel-Based Next-Generation Sequencing Method for ADME Genes Reveals Novel Associations of Common and Rare Variants With Expression in a Human Liver Cohort. Front Genet. 2019;10:7. doi: 10.3389/fgene.2019.00007. 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Studies are experimental investigations of a particular phenomenon, e.g., case-control studies on a particular trait or cancer research projects reporting matching cancer normal genomes from patients.
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