13384 results for ""60+mice"+"6+weeks"+diet+study+2014+2017+DOI"

in 38.27 milliseconds.

• Dac for "MediMer: A versatile do-it-yourself peptide-receptive MHC class I multimer platform for tumor neoantigen-specific T cell detection"

  Dac for the Study "MediMer: A versatile do-it-yourself peptide-receptive MHC class I multimer platform for tumor neoantigen-specific T cell detection" registered for Frank Momburg, f.momburg@dkfz-heidelberg.de Marten Meyer, marten.meyer@dkfz-heidelberg.de

  Dac EGAC50000000064

• Progressive multifocal leukoencephalopathy (PML)

  We generated RNAseq, ATACseq, Multiomics and CITEseq for patients with Progressive multifocal leukoencephalopathy (PML) to profile the chromatin accessibility, transcriptional profiles and surface proteins at single-cell level.

  Study EGAS50000000139

• Genomic analyses (WES, RNAseq, scRNAseq and scTCRseq) of triple negative breast cancer evolution

  This study explores the evolution of tumor and blood immune microenvironment and related mechanisms that shape breast cancer progression.

  Dataset EGAD50000000117

• Netherlands Cancer Institute (NKI-AVL) general DAC

  Data is available under reasonable request. All data requests will be reviewed by the NKI IRB and must be supported by the Principal Investigator of the study. The researcher will need to sign a data access agreement with the NKI after approval. Go to https://ega.nki.nl to fill out the form to request access.

  Dac EGAC50000000055

• The life-saving benefit of dexamethasone in severe COVID-19 is linked to a reversal of monocyte dysregulation

  Assessment of dexamethasone response in human lung through scRNA-seq analysis of bronchoalveolar lavage (BAL) samples from patients with severe COVID-19.

  Study EGAS50000000203

• INVADE cohort

  Cohort of bulk RNAseq data from DCIS, invasive and microinvasive breast cancer at diagnosis. This dataset covers 18 DCIS cases, 17 microinvasive and 20 primary invasive breast cancer.

  Study EGAS50000000219

• Genome Wide Association Studies in Alopecia Areata

  1054 unrelated alopecia areata patients were genotyped with the Illumina HumanHap550v3.0 genotyping chip. Allele frequencies were compared to publically available data from three population cohorts of controls.

  Study phs000586

• Antibody Repertoires in CVID

  The data consist of the DNA sequences of antibody gene rearrangements from peripheral blood human B cells of subjects with Common Variable Immune Deficiency (CVID) and healthy controls subjects.

  Study phs000934

• Treatment of genetic screening of hypertriglyceridemia type I, III, and V - HTG Amsterdam

  This is a cohort of patients with extreme hypertriglyceridemia. Patients have been screened for loss of function mutations in LPL, GPIHBP1, APOC2, APOA5 and LMF1.

  Study phs000511

• Human PI3Kγ Deficiency with Immunodeficiency and Tissue Immunopathology

  Whole exome sequencing of a trio (parents and offspring) reveals PIK3CG mutations that result in loss of protein in the child with immunodeficiency and immunopathology.

  Study phs001848

• TCRseq

  T cell receptor sequencing of tumor samples. Briefly, DNAse I treated tumor RNA samples were subjected to library preparation using AmpliSeq Immune Repertoire Panel (Illumina) and sequenced using NextSeq500.

  Study EGAS50000000258

• cfRRBS data plasma healthy donors

  This is cfRRBS data produced from the cfDNA in plasma isolated from healthy, adult donors. Used as a reference for background signal in diseased (onclolytic) plasma cfDNA.

  Study EGAS50000000376

• WES analysis of tumor samples

  Whole exome sequencing was performed on paired tumor (N=8) from ER+ advanced breast cancer, obtained prior to combined CDK4/6i and endocrine therapy and at disease progression.

  Study EGAS50000000430

• Whole Exome Sequencing of Multiple Myeloma Patients

  We used whole exome sequencing (WES) data from 35 MM patients to evaluate possible mutational signatures and driver mutations associated with the patient’s clinical and cytogenetic characteristics.

  Study EGAS50000000394

• Transcriptional Reference Map of Human Natural Killler Cells

  Here we performed single-cell RNA sequencing of both bulk NK and sorted NK subsets to establish a transcriptional reference map of human natural killer cells.

  Study EGAS50000000014

• Inherited defects of piRNA biogenesis cause transposon de-repression, impaired spermatogenesis, and human male infertility

  Effect of biallelic variants in genes of the piRNA pathway on biogenesis of pachytene piRNAs. RNA isolated from snap frozen testicular tissue

  Study EGAS50000000397

• Metabolic and molecular consequences of the TBC1D4 p.Arg684Ter variant in human skeletal muscle

  Skeletal muscle of Inuit homozygous carriers of the common Greenlandic TBC1D4 p.Arg684Ter variant is severely insulin resistant but have normal metabolic responses during exercise,

  Study EGAS50000000040

• Shallow Whole Genome Sequencing (sWGS) from REPEAT trial

  Samples associated to: "A phase Ib/II study of regorafenib and paclitaxel in patients with beyond first-line advanced esophagogastric carcinoma (REPEAT)". sWGS from 97 Esophagogastric Carcinoma samples. sWGS was done to carry out Copy Number Analysis. Dataset includes: .fastq, .bam and .bai files.

  Dataset EGAD50000001161

• Whole Exome Sequences from Eivissan and Menorcan Individuals

  We analyzed Exome sequences of present day Eivissan and Menorcan individuals in order to expand on the knowledge about their demographic history and its functional consequences.

  Study EGAS50000000428

• McQuillin_Global_London_SCZ_Bipolar_WES

  "McQuillin_Global_London_SCZ_Bipolar_WES. This research project was a collaboration between University College London, UK and the Stanley Center at the Broad Institute. In this project we sequenced and analyzed the whole exomes of 1,623 Schizophrenia and Bipolar case/control samples from collaborators in UK. Genomic DNA from each sample was sequenced to a mean depth of 20x. For EGA Study ID: 1128"

  Dac EGAC50000000311

• snRNA splicing signature RNA-Seq

  This dataset has RNA-Seq fastq files which were generated as part of the snRNA splicing signature study. Analysis can be performed to regenerate splicing signatures found for RNU4-2, RNU5B-1 and RNU5A-1 by comparing cases versus controls.

  Dataset EGAD50000001299

• Single-cell RNAseq of hematological toxicity following CAR-T cells injection

  Bone marrow aspirations obtained from patients treated with CAR-T cells were analyzed using single cell RNA sequencing (CD3+, CAR T+, CD34+ sorted populations).

  Study EGAS50000000776

• PRPH2-Related Retinal Dystrophies: Mutational Spectrum in 103 Families from a Spanish Cohort

  Various NGS experiments from patients affected by genomic variants at gene PRPH2, one of the most frequently inherited retinal dystrophy (IRD)-causing genes.

  Study EGAS50000000847

• Stanford Acute Myeloid Leukemia Single-Cell DNA Sequencing

  These are single-cell DNA sequencing data from acute myeloid leukemia samples from Stanford University. They were used in multiple publications to understand clonal evolution in AML.

  Study phs003853

• Melanoma transcriptomic data from patients undergoing immunotherapy

  This dataset contains raw RNA sequencing data from melanoma patient tumor samples collected before and during immunotherapy. The data support investigation of treatment-related changes in tumor cell populations. Samples were analyzed as part of a study exploring cellular responses to immune-based therapies.

  Dataset EGAD50000001569

• LongVar low-coverage data

  This dataset includes sequencing data from participants of the LongVar study. Specifically, it comprises low-coverage whole genome sequencing (WGS) data which was derived from cell-free DNA from blood samples. These data were generated to compare imputation accuracy. 133 individuals agreed to share their data, and are healthy volunteers.

  Dataset EGAD50000001607

• Exploring Genomic Mutations in Gastric Cancer among Japanese Populations

  We conducted a comprehensive analysis of whole-genome and RNA sequences obtained from biopsy samples of 65 patients with advanced gastric cancer prior to chemotherapy treatment.

  Study JGAS000754

• Integrated diagnosis based on transcriptome analysis in suspected pediatric sarcomas

  We performed RNA-sequencing in 47 patients with suspected pediatric sarcomas, to evaluate the potential utility of RNA-seq in the diagnostic process of pediatric sarcoma.

  Study JGAS000284

• Whole-genome-sequencing, Whole-exome-sequencing and RNA-sequencing in Sporadic ALS

  To identify the genetic cause and modifiers of Sporadic ALS, we performed Whole-genome-sequencing, Whole-exome-sequencing and RNA-sequencing of Sporadic ALS patients.

  Study JGAS000393

• p200503_fn1

  RNA-Sequencing data of tumor spheroids (HT-29) incubated with medium conditioned by Fusobacterium nucleatum treated CAFs (patient derived CAF20 and CAF32 as well as the CAF05 cell line).

  Study EGAS50000001120

• Olink Target Protein Expression

  Olink Target 96 Inflammation panels were applied to nasal secretions (DC, CRSsNP, CRSwNP, N-ERD, n=20 each). Across both panels, 184 assays (180 unique proteins) were determined, of which 4 appeared in both panels and were measured twice (CCL11, IL10, IL5, IL-6)

  Dataset EGAD50000001328

• DNA sequencing of sgRNAs enriched from the CRISPR-Cas9 screened HCC organoids

  There are 12 samples. The project aims to find enriched or depleted sgRNAs to identify functional genes in HCC progression and lenvatinib resistance

  Study EGAS50000001130

• cfDNA sWGS BAM — NSCLC stage I–III

  Plasma cfDNA sWGS for NSCLC patients (stage I–III), blood drawn pre-operatively, CHU Montpellier/LUNGDOC study. Libraries: DSP as recorded. Sequencing provider IntegraGen (2022–2024). Alignment to GRCh38 (hg38 canonical), BWA-MEM; BAMs sorted/indexed; only primary mapped reads retained (analysis pages list -F/MAPQ). Controlled access.

  Dataset EGAD50000001878

• Human colorectal cancer single-cell RNA sequencing

  The aim was to investigate changes in transcriptomics following irradiation. This was studied in colorectal cancer-patient derived organoids. Analysis was performed with scRNA-seq.

  Study EGAS50000001348

• Pediatric B-cell precursor acute lymphoblastic leukemia Micro-C sequencing

  This dataset included 35 childhood B-cell precursor (BCP) acute lymphoblastic leukemia Micro-C samples. All samples were subjected to Illumina pair-end sequencing.

  Study EGAS50000000764

• ctDNA detectability and representativeness in seven body liquids from female patients with metastatic breast cancer - lpWGS

  low-pass Whole Genome Sequencing (lpWGS) to assess the representativeness of seven body liquids from female patients with metastatic breast cancer.

  Study EGAS50000001302

• ctDNA detectability and representativeness in seven body liquids from female patients with metastatic breast cancer - WES

  Whole Exome Sequencing (WES) to explore the mutational status of seven body liquids from female patients with metastatic breast cancer.

  Study EGAS50000001303

• Bulk RNAseq dataset for "Longitudinal Multi-Omics Study Reveals Molecular Drivers and Tumor Microenvironment in Extramedullary Multiple Myeloma"

  This dataset contains 84 paired fastq files of Bulk RNAseq collected from 14 patients with Extramedullary multiple myeloma, 14 patients with newly diagnosed multiple myeloma and 14 patients with Relapsed/refractory multiple myeloma

  Dataset EGAD50000000051

• WGS analysis of a glioma initiating cell line

  We here obtained whole-genome sequencing data to analyze transcription factor binding sequences and somatic mutations found in our RNA-seq analysis of glioma initiating cells.

  Study JGAS000096

• Elucidation of molecular mechanism of NAFLD-HCC

  We analysed the somatic mutation profile of 69 genes with recurrent genetic alterations reported in HCC using surgically-resected tumor tissues of non-viral HCC patients.

  Study JGAS000523

• Targeted sequencing of cell free DNA samples from oligometastatic colorectal cancer patients

  In order to discover specific mutations that correlate with prognosis, target sequencing was performed using cell-free DNA samples from oligometastatic colorectal cancer patients.

  Study JGAS000196

• Target sequencing of refractory adult Ph-negative B-ALL 1 patient

  We performed target sequensing of the bone marrow samples to gain a better understanding of refractoriness in a case of adult Ph-negative B-ALL

  Study JGAS000483

• Metabolome analysis of persons with type 2 diabetes with or without diabetic complications

  We profiled serum metabolites of persons with T2D with or without diabetic complications using a comprehensive non-targeted metabolomics approach with mass spectrometry.

  Study JGAS000572

• Whole exome sequencing, RNA sequencing and single-cell RNA sequencing of 4 melanoma patients

  We perfomed whole exome sequencing and RNA sequencing of 4 melanoma patients to assess the detailed biological mechanisms of resistance to immune checkpoint inhibitors.

  Study JGAS000285

• Elucidation of male-specific genetic regulation through multi-layered omics analysis

  We performed single-cell RNA-sequencing of peripheral blood mononuclear cells from asthma patients and single-cell multiome (RNA+ATAC) profiling from COVID-19 patients.

  Study JGAS000862

• Single-cell transcriptomic data of 9 DHG-H3G34 patient tumors.

  We applied single-cell/single-nucleus RNA-sequencing to a patient cohort of 9 fresh and frozen untreated diffuse hemispheric gliomas, H3G34-mutant (DHG-H3G34).

  Study EGAS50000000534

• Epigenomic dataset of Human Hepatocellular Carcinoma for EpiHK

  This dataset is generated for EpiHK. It contains Histone PTM ChIP-seq, WGBS, RNA-seq of Human Hepatocellular Carcinoma and tumor adjacent normal tissue sample.

  Study EGAS50000000039

• Flexible and rapid validation of structural variants using adaptive sampling

  This is the DAC that oversees the application and approval process for access to the Oxford Nanopore fastq files associated with the study, "Flexible and rapid validation of structural variants using adaptive sampling". The DAC members include Dr. Stephen W. Scherer (swscherer@sickkids.ca) and Dr. Lars Feuk (lars.feuk@igp.uu.se).

  Dac EGAC50000000748

• Circulating immune cell landscape in colorectal cancer patients

  To understand the circulating immune cells in colorectal cancer patients, we performed single-cell RNA sequencing for 14 PBMC samples from 14 colorectal cancer patients.

  Study EGAS50000000590

• WGS of all Patients Listed within this Study

  This dataset contains WGS from whole blood of patients II.2, II.3, III.1-4 and WGS from fibroblasts of patients III.2 and III.3. All WGS was performed on an Illumina NextSeq2000 to a minimum depth of 250 million read pairs (2x150nts).

  Dataset EGAD50000002362