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• African Demographic History Study Based on WGS Data

  These data were used as part of a study to characterize genomic diversity in Africa, population substructure, and evolutionary history.

  Study phs003096

• Multimodal single-cell analyses of peripheral blood mononuclear cells in COVID-19 patients

  10x scRNA and 10X scVDJ analyses were performed using PBMCs collected from COVID-19 patients in Japan.

  Study JGAS000546

• Analysis of Multiparametric MR imaging and tumor tissue sampling to identify response and acquired resistance to HIF-2 inhibition in patients with advanced clear cell renal cell carcinoma enrolled in a phase 1, multiple-dose, dose-escalation trial of PT2385, a HIF-2alpha inhibitor

  Study EGAS00001003506

• Human non-malignant plasma cfRNA study - raw data

  mRNA capture sequencing on plasma sample from 88 patients with a non-malignant disease and from 37 healthy donors.

  Study EGAS50000001264

• RNA-seq in LCLs derived from constitutional MLH1 epimutation carriers and non-carrier relatives

  RNA-seq in LCLs derived from constitutional MLH1 epimutation carriers and non-carrier relatives to investigate alterations in gene expression associated with MLH1 epimutation

  Dataset EGAD50000000712

• scRNA and spatial-seq of human skin wound healing

  Human skin acute wound healing contains 12 samples of scRNA-seq and 16 samples of spatial transcriptomics, Human skin chronic wound data contains 9 samples scRNA-seq.

  Dataset EGAD50000000813

• Biological and Therapeutic Implications of a Unique Subtype of NPM1 Mutated AML (RNAseq Data)

  This dataset contains 91 RNAseq paired reads, in fastq format. Samples were collected from fresh bone marrow and peripheral blood sample from AML patients.

  Dataset EGAD00001006669

• Exome_sequencing_of_short_SGA_children_with_IGF_I_and_insulin_resistance

  Exome sequencing of short SGA children with IGF-I and insulin resistance. Collaboration with Professor David Dunger, University of Cambridge. Funded by NIHR.

  Study EGAS00001001086

• Colorectal_organoids_and_tumoroids___pulldown

  Targeted capture of cancer gene panel bait set in single cell derived organoids from colon tissue and colorectal cancer from 1 patient.

  Study EGAS00001000869

• GWAS in a dengue Thai cohort

  Around 700,000 SNPs were genotyped in 290 controls, 252 dengue fever patients and 159 dengue shock syndrome patients from Thailand.

  Study EGAS00001002756

• HCA_Thymus_Paediatric_CZI_Spatial

  Spatial transcriptome analysis of thymic cells from children with syndromic diseases such as Trisomy 21 and inflammatory/autoimmune diseases such as myasthenia gravis.

  Study EGAS00001006156

• 1_RNAseq_sALS_Ctrl

  iPSC-derived motor neurons form sporadic ALS and Controls. 4 sALS iPSC lines and 4 Ctrl iPSC lines.

  Dataset EGAD00001008424

• 18 plasma samples and their paired 18 urinary cfDNA samples without cancer

  18 plasma samples and their paired 18 urinary cfDNA samples without cancer

  Dataset EGAD00001009839

• Human primary and metastatic colorectal cancer (CRC) samples

  Bank of human both primary and metastastic colorectal cancer sample RNAseq

  Dataset EGAD00001009712

• Whole exome and RNA sequencing of 5 samples of patient-derived xenograft (PDX).

  Whole exome and RNA sequencing of 5 samples of patient-derived xenograft (PDX). Available files are raw sequencing fastq files.

  Dataset EGAD00001010102

• Whole exome sequencing of breast cancer samples pre- and post-neoadjuvant chemotherapy (NAC)

  Fastq files resulting from whole exome sequencing of trios of samples from 6 breast cancer patients: normal breast, pre-NAC biopsy and post-NAC surgical resection.

  Dataset EGAD00001004984

• RNA Sequencing of mCRC xenografts under cetuximab treatment.

  RNA sequencing on cetuximab treated, untreated and release samples of one metastatic colorectal xenograft. 3 cetuximab treated samples, 3 placebo and 3 release - paired fastq.

  Dataset EGAD00001005185

• Targeted sequencing data of breast tumors with germline BRCA1/2 mutations

  This dataset contains targeted sequencing of breast tumors with germline BRCA1/2 mutations (n = 30) and those without. Breast cancer related genes (n = 115) have been captured and sequenced.

  Dataset EGAD00001005802

• Sequencing of uveal melanoma metastases

  Whole genome, exome and RNA sequencing of uveal melanoma metastases, primary tumors and matched normal DNA.

  Dataset EGAD00001006031

• TREM2+ Cells in Human Basal Cell Carcinomas

  To explore the tumor immune microenvironment heterogeneity in sporadic human basal cell carcinoma tumors, we profiled two individual patient tumors by scRNA-Seq. We identified a population of TREM2+ macrophages, which have been implicated in promoting an immunosuppressive tumor microenvironment. We identify that TREM2+ can promote tumor epithelial proliferation in an immunosuppressive independent manner.

  Study phs003242

• NABUCCO cohort 1 (NCT03387761) - Neo-Adjuvant Bladder Urothelial Carcinoma COmbination-immunotherapy

  NABUCCO cohort 1 sequencing data. The dataset includes: * Whole exome DNAseq pre-treatment on tumor samples (n=24) matched with blood samples (n=24) * RNAseq pre-treatment on tumor samples (n=18) * RNAseq post-treatment on tumor samples (n=18). Not all pre-treatment samples are linked with pre-treatment samples * High coverage Whole exome DNAseq on pre-treatment tumor samples (n=3) matched with post-treatment metastasized lymph nodes isolated with laser microdissection (n=3) * All samples are labelled with the response phenotype (Complete Responder or Non-Complete Responder)

  Dataset EGAD00001006250

• Exome sequencing samples from the Acute Care Flagship.

  Exome sequencing samples from the Acute Care Flagship, Illumina sequencing.

  Dataset EGAD00001008105

• VCF dataset of Colorectal Cancer Synthetic genomes

  This dataset contains genomic variants data from VCF files of four patients synthetically generated in the EOSC4Cancer project

  Dataset EGAD50000000314

• cfRRBS data plasma healthy donor

  cfRRBS data produced from the cfDNA in plasma isolated from healthy, adult donors.

  Dataset EGAD50000000553

• VCF file, post sample QC

  This VCF contains the full sequence data post QC. This consists of 41,911 individuals. All polymorphic sites are present in this VCF.

  Dataset EGAD00001000623

• 46 VCF files of glioma patient 2021

  the source data in VCF format of 46 patients primary malignant glioma cohort in Chinese population

  Dataset EGAD00001008115

• Bulk RNA-seq osteosarcoma

  We profiled 23 patient osteosarcoma tumor samples by bulk RNA-seq. The raw fastqs are provided.

  Dataset EGAD00001011371

• The Ashkenazi Genome Consortium: Phase I

  Whole genome, high coverage, sequencing of 128 Ashkenazi Jewish controls

  Dataset EGAD00001000781

• Cloning of the breakpoint of a novel translocation associated with T-acute lymphoblastic leukaemia

  Single case of T-ALL carrying t(4;6), a novel translocation.

  Dataset EGAD00001002193

• Whole exome sequence in EGFR-TKI resistant non-small cell lung cancer

  Whole exome analysis to clear molecular basis and mutation spectrum in EGFR-TKI resistant non-small cell lung cancer

  Study JGAS000102

• RNAseq of idelalisib treated CLL patients

  RNAseq of paired samples of CLL patients from before and during idelalisib therapy in vivo (n=18 samples from 9 patients).

  Study EGAS50000000620

• RNAseq of ibrutinib treated CLL patients

  RNAseq of paired samples of CLL patients from before and during ibrutinib therapy in vivo (n=22 samples from 11 patients).

  Study EGAS50000000621

• WGBS of patients from six tumor types

  This dataset contains healthy and tumor samples from patients covering breast adenocarcinoma, colon adenocarcinoma, kidney renal clear cell carcinoma, hepatocellular carcinoma, lung adenocarcinoma and pancreas adenocarcinoma.

  Dataset EGAD50000001318

• T-ALL and Thymus 10x genomics immune profiling

  10x Genomics immune profiling including sequenced libraries of: 5'-end mRNA transcriptomics Beta and alpha chain VDJ transcripts Cell surface expression by 204 DNA barcoded antibodies

  Dataset EGAD50000000533

• cfDNA methylation profiling on longitudinally collected blood plasma of patients with esophageal adenocarcinoma

  cell-free Reduced Representation Bisulfite Sequencing (cfRRBS) data from blood plasma and FFPE tissue samples from patients with esophageal adenocarcinoma, and blood plasma of healthy donors.

  Dataset EGAD50000000734

• ATAC-seq in LCLs derived from constitutional MLH1 epimutation carriers and non-carrier relatives

  ATAC-seq performed in LCLs derived from constitutional MLH1 epimutation carriers and non-carrier relatives to profile alterations in chromatin accessibility associated with constitutional MLH1 epimutation.

  Dataset EGAD50000000714

• H3K27ac ChIP-seq and RNA-seq of lung neuroendocrine tumors

  H3K27ac ChIP-seq and RNA-seq of lung neuroendocrine tumors

  Dataset EGAD50000000083

• Cancer Genome Scanning in Plasma: Detection of Tumor-Associated Copy Number Aberrations, Single-Nucleotide Variants, and Tumoral Heterogeneity by Massively Parallel Sequencing

  Cancer Genome Scanning in Plasma: Detection of Tumor-Associated Copy Number Aberrations, Single-Nucleotide Variants, and Tumoral Heterogeneity by Massively Parallel Sequencing

  Dataset EGAD00001000290

• Cancer Genome Scanning in Plasma: Detection of Tumor-Associated Copy Number Aberrations, Single-Nucleotide Variants, and Tumoral Heterogeneity by Massively Parallel Sequencing

  Cancer Genome Scanning in Plasma: Detection of Tumor-Associated Copy Number Aberrations, Single-Nucleotide Variants, and Tumoral Heterogeneity by Massively Parallel Sequencing

  Dataset EGAD00001000284

• Biological and Therapeutic Implications of a Unique Subtype of NPM1 Mutated AML (ATACseq Data)

  This dataset contains 18 ATACseq reads, in fastq format. Samples were collected from fresh bone marrow and peripheral blood sample from AML patients.

  Dataset EGAD00001006670

• Whole exome sequencing of peripheral T-cell lymphoma (PTCL)

  Somatic mutations in 3 AITL and 3 PTCL, not otherwise specified (PTCL-NOS) specimens were explored using whole-exome sequencing.

  Study EGAS00001000557

• Breast_cancer_topographs

  Breast cancer topography will be explored using a combination of multi-region whole geome sequencing and in-situ RNA sequencing of fixed tissue specimens.

  Study EGAS00001003698

• anti-SARS-CoV-2 IgG and Fostamatinib treated human primary IL10-M2 macrophages

  RNA sequencing data of anti-SARS-CoV-2 spike IgG (monoclonal or patient serum), poly(I:C) and Fostamatinib treated human primary IL10-M2 macrophages

  Dataset EGAD00001007512

• Clinical data

  Clinical data from this cohort of patients, including hormone sensitive or castration resistant prostate cancer, overall survival, NMF subtypes, tumor TMB, prior treatment status, PD-L1 IC and TC scores from SP142 and SP263 as well as percentage of CD8 IHC at tumor center.

  Dataset EGAD00001008761

• Medulloblastoma Nanopore whole genome sequencing 3 samples

  ONT (PromethION) sequencing of chromothriptic medulloblastoma. Three samples: blood, primary tumor, and relapse tumor. Includes a fourth low-coverage run that multiplexes blood and primary tumor.

  Dataset EGAD00001009411

• Microhaplotype amplicon sequencing of cervical samples and controls

  Microhaplotype amplicon sequencing of cervical samples (n=10), parental DNA (n=20), cfDNA (n=10) and control experiments using HapMap DNA in different spike-in percentages.

  Dataset EGAD00001010120

• patient-derived head and neck cancer organoids

  patient-derived head and neck cancer organoids

  Dataset EGAD00001010134

• scTCR analysis of CD8 T-cells from blood, fat, liver and skin

  CD8 Tcells were FACS sorted and processed with 10x Genomics Chromium Next GEM SingleCell V(D)J Reagents Kits v1.1 sequencing. In total 6 samples were processed. Fastq files are supplied.

  Dataset EGAD00001010005

• Single-cell multidimensional profiling of tumor cell heterogeneity in supratentorial ependymomas

  55 Supratentorial Ependymomas patient samples were sequenced scRNA-sequencing using Smart-Seq2 and 10x protocol (51 samples) and 10x Genomics protocol (4 samples) on a NextSeq 550 sequencer (Illumina).

  Dataset EGAD50000002186

• Next Generation Children Project

  Whole genome sequencing of sick children in neonatal and paediatric intensive care units. Datasets EGAD00001007780 (GRCh37) and EGAD00001007868 (GRCh38) are extentions of this dataset.

  Dataset EGAD00001004357