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• An ancient DNA perspective on the Russian Conquest of Yakutia

  Yakut communities from northeastern Siberia inhabit some of the coldest environments on Earth preserving an extraordinary archaeological record. Their history was profoundly reshaped by the Russian conquest, which introduced cereals, pathogens and Christianity from 1632 CE. However, the biological impact of these transformations remains unknown. Here, we generated extensive ancient DNA data to elucidate contemporary changes in Yakut genomic diversity and oral microbiomes. We found Yakut origins tracing back to local populations that admixed with trans-Baikal groups migrating as the Great Mongol Empire spread. Despite the Russian conquest, the Yakut gene pool and oral microbiomes appeared largely stable, though smallpox strains distinct from those documented in Europe by ~1650 CE circulated. Marital practices generally maintained low consanguinity, with the exception of one female bearing the latest markers of traditional shamanism, who was the daughter of second-degree relatives.

  Study EGAS50000001329

• Genetic Mechanisms of Disease Lab DAC

  Data access for raw and processed H3K27ac ChIP-seq and ATAC-seq data from "Effect of ETS2 modulation on chromatin accessibility and enhancer activity in human macrophages".

  Dac EGAC50000000087

• Small RNA sequencing dataset from human prefrontal cortex tissue - ALS vs CTR

  For mature miRNAs and hairpins, BAM and FASTq files

  Dataset EGAD50000000468

• TOAPR-B patient cell-free DNA WGS and WES

  Sequencing files for TOPARP-B patients as described in manuscript

  Dataset EGAD50000000407

• Genentech_cell_line_SNP

  SNP array data for 668 cancer cell lines

  Dataset EGAD00010000951

• DATA FILES FOR SJHYPO

  Hypodiploid acute lymphoblastic leukemia whole genome sequencing

  Dataset EGAD00001000260

• Reference epigenome DB31_N_Alpha_WGBS data generated from KEP study

  A DB31_N_Alpha_WGBS paired end data for alpha cells(PSA-NCAM(-), pancreas)

  Dataset EGAD00001003472

• Reference epigenome ADMSC01_ChIP-Seq(H3K27me3) data generated from KEP study

  A ADMSC01_ChIP-Seq(H3K27me3) paired end data for adipose-derived mesenchymal stroaml cells

  Dataset EGAD00001003854

• Reference epigenome ADMSC02_ChIP-Seq(H3K27me3) data generated from KEP study

  A ADMSC02_ChIP-Seq(H3K27me3) paired end data for adipose-derived mesenchymal stroaml cells

  Dataset EGAD00001003855

• Reference epigenome ADMSC03_ChIP-Seq(H3K27me3) data generated from KEP study

  A ADMSC03_ChIP-Seq(H3K27me3) paired end data for adipose-derived mesenchymal stroaml cells

  Dataset EGAD00001003856