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• Tagomics Ltd

  The Tagomics Ltd Data Access Committee manages controlled access to datasets generated by Tagomics Ltd. The DAC evaluates applications to ensure that proposed research complies with participant consent, ethical approvals, and institutional policies.

  Dac EGAC50000000727

• Reconstruction of the microbial genomes from the Japanese gut metagenome

  We performed a metagenome shotgun sequencing to identify the microbial features of Japanese.

  Study JGAS000531

• Single cell RNAseq of PDAC organoids

  To study the role of WNT7B, three organoid lines were sequenced using SORT-Seq

  Study EGAS50000001544

• Large scale familial CRC exome sequencing study

  The burden of rare disruptive mutations to the heritable risk of colorectal cancer

  Study EGAS00001001666

• Hearing_loss_in_adults_from_South_Carolina_

  DNA from ten individuals from South Carolina with progressive hearing loss will be subjected to exome sequencing

  Study EGAS00001000157

• MSI_Cancer_Models___RNAseq

  The study will use RNAseq to aid in define determinants of WRN dependency in MSI Cell lines.

  Study EGAS00001004180

• CMF RNA sequencing

  RNA sequencing will be undertaken to reconstruct rearrangements at level of transcription to determine pathogenomic genomic events in chondromyxoid fibroma.

  Dataset EGAD00001000824

• RNA-seq of iPSC-derived oligodendrocytes of individuals with and without t(1;11) translocation

  This dataset contains high-throughput RNA-sequencing of 14 samples, each sample comprising oligodendrocytes derived from human induced pluripotent stem cells, from individuals with and without a balanced t(1;11) translocation which substantially increases risk of major mental illness. 5 samples derive from 2 control individuals, and 9 samples from 3 individuals carrying the translocation. Libraries were prepared from each total-RNA sample using the TruSeq Stranded Total RNA with Ribo-Zero kit. Libraries were then sequenced using the NextSeq 500/550 High-Output v2 (150 cycle) Kit on the NextSeq 550 platform. Raw paired-end sequencing data is stored in two FASTQ files per sample.

  Dataset EGAD00001006341

• sWGS on cfDNA and matching tumor DNA in pediatric cancer

  This dataset contains shallow whole genome sequencing data from paired cfDNA - tumor DNA samples of various pediatric cancer entities (total 215 samples). Files are provided in fastq format. Samples were sequenced on an Ion Proton sequencer (Thermo Fisher Scientific) or a Hiseq3000 (Illumina). Data analysis is available at https://github.com/rmvpaeme/sWGS_pediatric_cancer.

  Dataset EGAD00001007508

• Therapy-Induced APOBEC3A Drives Evolution of Resistance to Targeted Therapies in Non-Small Cell Lung Cancer

  The purpose of this study was to identify mechanisms of resistance and associated mutational signatures in non-small cell lung cancers (NSCLCs) treated with targeted therapies. Whole genome sequencing (WGS) and whole exome sequencing (WES) were performed on tumor tissue or cell lines derived from oncogene-driven NSCLCs before and after treatments with tyrosine kinase inhibitors. Somatic mutations were called and mutational signature analysis was performed, revealing enrichment of APOBEC mutational signatures mutational signatures in post-treatment tumors after the development to resistance to targeted therapies. The cohort includes WGS and WES data of tumor and normal tissues from patients with oncogene-driven NSCLCs harboring EGFR mutations, ALK fusions or NTRK1 fusions, who were treated with molecularly targeted therapies that target these oncogenes.

  Study phs003256