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• Targeted de novo phasing and long-range assembly by template mutagenesis

  Study EGAS00001005899

• Sequencing Data of HGSC patient-derived cell lines and organoids

  Study EGAS00001006557

• Whole Exome and RNA sequencing of synchronous female bilateral breast cancers

  Study EGAS00001006910

• Whole genome, RNA-seq and single-cell Multiome profile of multiple myeloma

  Study EGAS00001007014

• DNA methylation

  CASE AND CONTROL SAMPLES USING Infinium MethylationEPIC

  Dataset EGAD00010001805

• Analysis scripts

  Analysis scripts and output

  Dataset EGAD00001003282

• anonymized_capTCRseq

  TCR-beta sequences, frequencies, and VDJ usage.

  Dataset EGAD00001008791

• single cell RNA-seq and ATAC-seq of human fetal forebrain tissue

  Oligodendrogenesis in the human central nervous system has been mainly observed at the second trimester of gestation, a much later developmental stage compared to mouse. Here we characterize the transcriptomic neural diversity in the human forebrain at post conceptual weeks (PCW) 8 to 10, using single-cell RNA-Seq. We find evidence of the emergence of a first wave of oligodendrocyte lineage cells as early as PCW 8, which we also confirm at the epigenomic level with single-cell ATAC-Seq. Using regulatory network inference, we predict key transcriptional events leading to the specification of oligodendrocyte precursor cells (OPCs). Moreover, by profiling the spatial expression of fifty key genes using In Situ Sequencing (ISS), we identify regions in the human ventral fetal forebrain where oligodendrogenesis first occurs. Our results indicate evolutionary conservation of the first wave of oligodendrogenesis between mouse and human and describe regulatory mechanisms involved in human OPC specification.

  Study EGAS00001006136

• Department of Pathology and Tumor Biology, Kyoto University Data Access Committee

  Dac EGAC00001000273

• small RNA-Seq and RNA-Seq of cortical tubers from sufferers of tuberous sclerosis complex

  Dac EGAC00001000672

• RNA sequencing data of 66 matched primary and recurrent high grade serous ovarian cancer

  Dac EGAC00001000741

• Naive B-cell receptor heavy chain repertoire of celiac patients and healthy controls - DAC

  Dac EGAC00001001072

• Human T-bet governs innate and innate-like adaptive IFN-g immunity against mycobacteria

  Dac EGAC00001001822

• PELICAN45 and GP21 prostate cancer studies Data Access Committee

  Dac EGAC00001001309

• Stability of gut microbiome after COVID-19 vaccination in healthy and immuno-compromised individuals

  Dac EGAC50000000123

• Volkov Data Access Committee

  Sequencing and analysis data supporting published work of Hadas Volkov

  Dac EGAC50000000907

• Platelets sequester extracellular DNA, capturing tumour-derived and free fetal DNA

  Study EGAS00001006854

• Single-cell sequencing of adipose-derived mesenchymal stromal cells and dermal fibroblasts

  Study EGAS00001006954

• Whole-genome and transcriptome sequencing of blastic plasmacytoid dendritic cell neoplasm

  Study EGAS00001003660

• scATAC-seq and combined scRNA-seq of the human first trimester neurodevelopment

  Study EGAS00001007472

• Integrative pan-cancer genomic and transcriptomic analyses of refractory metastatic cancer

  Study EGAS00001006648

• Epigenome-wide association study of asthma remission in whole blood and nasal epithelium

  Study EGAS00001004766

• Detailed molecular and immune marker profiling of archival prostate cancer samples

  Study EGAS00001004396

• Sensitive and reproducible cell-free methylome quantification with synthetic spike-in controls

  Study EGAS00001005069

• Methylation clocks - individual colon, small intestine and endometrial crypts

  Study EGAS00001005514