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• Single-cell multi-omics of human clonal hematopoiesis reveals that DNMT3A R882 mutations perturb early progenitor states through selective hypomethylation.

  We profiled CD34+ enriched cells from GCSF mobilized bone marrow samples (n = 4) using single-cell RNA sequencing (10X) with targeted genotyping, and single-cell DNA methylation (RRBS) with single-cell RNA sequencing (Smart-Seq2) and targeted genotyping. A 5th CH bone marrow aspirate sample was obtained to validate observed results.

  Dataset EGAD00001008985

• Reference alignment files (BAM) and gene count files of 10 tumor samples from nanopore sequencing

  Reads were aligned to 1000 Genomes assembly reference (hs37d5) using minimap2 2.22. SAM-to-BAM conversion, BAM sorting and indexing were performed with SAMtools 1.13. Read summarization was performed with featureCounts (from Subread 2.0.3) over exon features based on GENCODE Version 19 gene models. Strand specific counting was used.

  Dataset EGAD00001009690

• RNA-seq of PDAC patient-derived xenograft tumors

  This dataset contains single cell RNA-seq data of stromal cells derived from two PDX models (N = 2 in total) and bulk RNA-seq data of two PDX models treated with gemcitabine and our novel antibody-drug conjugate, C6-EBET (N = 59 in total). Bulk RNA-seq experiments were performed with Agilent SureSelect Strand Specific RNA Library Prep Kit (Agilent). Single cell RNA-seq experiments were performed with Chromium Single Cell 3' Reagent Kits v2 Chemistry (10x Genomics).

  Dataset EGAD00001010130

• Differential Presence of Exons in Cell-Free DNA Reveals Different Patterns in Colorectal Cancer Between Metastatic and Non-Metastatic Patients

  Dac EGAC00001000749

• Multi-focal genomic dissection of synchronous primary and metastatic tissue from de novo metastatic prostate cancer - Data Access Committee

  Dac EGAC00001002905

• INCLIVA-CC-WES DAC

  Localised colon cancer WES study contaning WBCs, tissue and plasma samples at different time points

  Dac EGAC50000000156

• Genetic drivers define transcriptomic characteristics and clonal hierarchy within intratumoral heterogeneity in adult T-cell leukemia-lymphoma

  Study JGAS000301

• Two monogenic disorders masquerading as one: Severe congenital neutropenia with monocytosis and non-syndromic sensorineural hearing loss

  Study EGAS00001004176

• Spatiotemporal single cell transcriptomic analysis of human gut macrophages reveals multiple functional and niche-specific subsets

  Study EGAS00001005377

• Case Report: early contribution of germline and nevi genetic alterations to a rapidly-progressing Cutaneous Melanoma Patient

  Study EGAS00001006459

• Pleural_mesothelioma

  EPIC methylation data of pleural mesothelioma samples and healthy pleura samples

  Dataset EGAD00010002657

• Healthy_pleura

  EPIC methylation data of pleural mesothelioma samples and healthy pleura samples

  Dataset EGAD00010002656

• USA-Immuno

  USA Multiple Sclerosis cases and controls

  Dataset EGAD00010002043

• yemcha-U-2

  Yemen and Chad Genotyping

  Dataset EGAD00010001867

• REL-2017-07-2013

  HipSci - Bleeding and Platelet Disorders - Genotyping Array - July 2017

  Dataset EGAD00010001360

• MacTel_cohort_Omni5_genotypes

  MacTel Projet consortium case and control genotypes from Ilumina Omni5 chip

  Dataset EGAD00010001204

• Clinical and genetic analysis of a rare syndrome associated with neoteny

  Dataset EGAD00001003593

• Whole-exome and low-coverage whole genome sequencing data

  Dataset EGAD00001001391

• Whole-Genome Bisulfite Sequencing of a paired initial and recurrent glioma

  Dataset EGAD00001001616

• DONSON exome data

  Exome data from patients and parents with DONSON mutations

  Dataset EGAD00001003160

• 20210708_EGA_Melanoma_mk2 WGS 570 donors

  Illumina platform whole genome sequencing data for matched tumour-normal DNA samples from 570 melanoma patients

  Dataset EGAD00001008798

• Data Access Commitee - Monocyte and macrophage lipid accumulation results in downregulated type-I interferon responses - FH monocytes RNA sequencing data

  Dac EGAC00001002495

• Time series analysis of neoadjuvant chemotherapy and bevacizumab treated breast carcinomas reveals a systemic shift in genomic aberrations

  Study EGAS00001003287

• IMPRESS: Improved Methylation Profiling using Restriction Enzymes and smMIP Sequencing, Combined with New Biomarker Panel, Creating Multi-Cancer Detection Assay

  Study EGAS00001007559

• DNA polymerase and mismatch repair deficient cancers exert distinct genome-wide microsatellite signatures 2

  Study EGAS00001004816

• Single cell characterization of arrested B-lymphoid differentiation and leukemic cell states in ETV6-RUNX1-positive pediatric leukemia

  Study EGAS00001004374

• Longitudinal monitoring of disease burden and response using ctDNA from dried blood spots in xenograft models

  Study EGAS00001006134

• Complex patterns of genomic heterogeneity identified in 42 tumor samples and ctDNA of a pulmonary atypical carcinoid patient

  Study EGAS00001006530

• Patient-derived organoids identify tailored therapeutic options and determinants of plasticity in sarcomatoid urothelial bladder cancer

  Study EGAS00001007430

• Panamanian genotype data

  84 Indigenous and admixed individuals from Panama genotyped with Axiom Human Origins (Affymetrix)

  Dataset EGAD00010002473

• HomoCulturGen

  86 samples from four human populations: two from Central Asia and two from Southeast Asia

  Dataset EGAD00010002663

• Germany-Immuno

  Germany Multiple Sclerosis cases and normal controls

  Dataset EGAD00010002044

• Belgium-Immuno

  Belgium Multiple Sclerosis cases and normal controls

  Dataset EGAD00010002045

• France-Immuno

  France Multiple Sclerosis cases and normal controls

  Dataset EGAD00010002046

• AUSNZ-Immuno

  Australia and New Zealand Multiple Sclerosis case

  Dataset EGAD00010002047

• OGVP_HC24_Controls

  Healthy adult volunteers and newborns recruited in various countries across Oceania.

  Dataset EGAD00010000953

• BCC exomes and transcriptomes

  Dataset EGAD00001001857

• Summary data from case control analysis

  Summary data from GWAS analysis on 856 cases and 2836 control

  Dataset EGAD00000000115

• EGAD00000000059

  Aggregate results from 43 Carbamazepine-induced hypersensitivity syndrome patients and 1296 1958 British Birth Cohort control samples

  Dataset EGAD00000000059

• Chair of Experimental Medicine and Therapy Research Regensburg DAC

  Dac EGAC00001001699

• DupiAERD DAC

  DAC to regulate access to RNA sequencing data of NERD patients with dupilumab treatment before and after aspirin provocation.

  Dac EGAC50000000273

• RNA sequencing of in vitro generated suppressive myeloid cells using parental and Sialidase expressing A549 cancer cell lines

  Study EGAS00001007618

• RNA-seq on neuroblastoma PDX model COG-N-519 treated with control miR-1283 and test miR-99b-5p mimics

  Study EGAS00001005368

• transcriptome analysis of NK cells sorted from PBMCs at baseline and after addition of a T cell dependent bispecific antibody (TDB)

  Study EGAS00001006914

• SNParray_CASCADE

  Tumor and matched normal DNA profiling by SNP array

  Dataset EGAD00010002398

• SNParray_MOCOG

  Tumor and matched normal DNA profiling by SNP array

  Dataset EGAD00010002359

• NSAID-LIV

  1000G Phase 3 Imputed cases and controls from NSAID-induced PUD study

  Dataset EGAD00010001422

• 1506_Methylation_M.vd.Berge

  DNA methylation in bronchial biopsies of asthmatics, asthma in remission and healthy subjects

  Dataset EGAD00010001731

• Thai Cases

  252 dengue fever patients and 159 dengue shock syndrome patients

  Dataset EGAD00010001487

• OCAC OncoArray data

  Germline genotype data on 56,479 ovarian cancer cases and controls

  Dataset EGAD00010001192