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• Total RNAseq in the sporadic ALS and healthy control motor cortex

  Dac EGAC00001001515

• Raw sequencing data of PERMED-01 trial

  Targeted sequencing (t-NGS) of frozen advanced cancers tissue was established with three panels covering 395 to 560 candidate cancer genes. Sequencing was done using the 2x150-bp paired-end technology on the Illumina MiSeq and NextSeq500 platforms. The DNA libraries of all coding exons were done with the HaloPlex Target Enrichment System (Agilent, Santa Clara, CA, USA).

  Dataset EGAD00001006289

• WGS of cfDNA in PDAC Breast Cancer and Matched Controls

  This dataset contains WGS data derived from plasma cfDNA. The cohort includes PDAC and breast cancer patients alongside matched controls. These data are intended to support research into ctDNA and genomic fragmentation patterns.

  Dataset EGAD50000002323

• Targeted sequencing of intestinal metaplasia

  We perform targeted DNA sequencing of intestinal metaplasia of 463 IM and paired germline samples. An additional 48 IM and paired germline samples were included as validation cohort. The dataset contains cram files from 1022 IM and paired normal samples.

  Dataset EGAD50000001540

• Single-cell somatic copy number variants in brain using different amplification methods and reference genomes

  This dataset contains 224 paired fastq files (112 single cells) from the following samples: brains from two Multiple System Atrophy patients and one control, and non-brain controls (fibroblasts, NA12878)

  Dataset EGAD50000000030

• WGS of HSPCs and MSCs

  Whole genome sequencing data of organoid cultures derived from human bone marrow-derived and cord blood-derived hematopoietic stem and multipotent progenitor cells to study the mutation accumulation.

  Dataset EGAD00001004451

• Matched FF and FFPE WGS from a metastatic prostate tumor

  This dataset contains three bam files. One normal blood sample and two matched FF and FFPE samples from the same metastatic prostate tumor.

  Dataset EGAD00001006180

• Molecular Characterization of Germ Cell Tumors

  We performed comprehensive molecular profiling of germ cell tumors, including whole exome sequencing and transcriptome sequencing, derived from patient samples. This project additionally explores mechanisms of chemosensivity in these patients, as well as mechanisms of tumor evolution in the context of treatment.

  Study phs000923

• Effects of KSP inhibitor filanesib in aggressive hepatoblastoma PDX cells

  Aim of this RNA sequencing dataset has been to asses effects caused by the KSP inhibitor filanesib in aggressive hepatoblastoma PDX cells. Two cell lines (HB-279 and HB-284) were utilised. DMSO-treated cells were used as controls.

  Study EGAS50000000899

• WES data from primary CRCs tissues in ctDNA positive patients

  Whole exome data from primary colorectal cancer tissue samples were analysed in patients where mutations where found in circulating tumour DNA. DNA was extracted from FFPE blocks and exome libraries were prepared using the KAPA HyperPlus Kit (Roche diagnostics)

  Study EGAS50000000650