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• Novel genome editing strategies to uncover genotype-phenotype correlations in Polycystic Kidney Disease: a proof-of-concept

  Bulk RNA-seq of genome-edited HEK293T cell lines engineered to model specific PKD1 variants. This dataset enables the exploration of genotype-phenotype correlations in Polycystic Kidney Disease (PKD)

  Study EGAS50000001188

• Longitudinal RNA-seq (whole blood) in a twin cohort

  The dataset consists of 232 RNA-seq samples (whole blood) obtained from healthy female from the TwinsUK adult registry cohort. The samples were obtained at two time points separated on average by 22 months.

  Study EGAS00001001763

• A single-cell atlas of meningioma

  To explore meningioma intra-tumoral heterogeneity at scale, we generated the largest cohort profiled to date with single-nuclear RNA sequencing (snRNAseq, n = 102 samples and 580,185 high-quality nuclei) as well as high-resolution spatial transcriptomics (Visium HD, n = 43 samples and 7,146,538 115 segmented cells).

  Dataset EGAD50000002272

• Whole genome sequencing of patient derived cancer and normal organoids

  The dataset includes whole genome sequencing data generated from regional patient derived colorectal cancer (CRC) and adjacent normal tissue organoids. The dataset contains samples from a total of 10 different early CRC biobank patients from 2 different sequencing runs.

  Dataset EGAD50000002204

• M116 Whole Genome Bisulphite Sequencing

  DNA fragmentation from M116 blood sample (350 bp), library preparation, bisulfite conversion, and paired-end-150 whole genome bisulfite sequencing was conducted by Novogene®. Sequencing was carried out with a 10X coverage (approximately 60 Gb and 200 million reads per sample) using the NovaSeq X Plus platform (Illumina). Files types included in this dataset are raw Fastq files.

  Dataset EGAD50000001285

• Purified vs unpurified stem cell-islets

  A scRNAseq dataset consisting of stem cell-derived islets treated with gradient separation (HUES8_Pure_Islets) and unpurified control (HUES8_control_islets). scRNAseq was done on cryopreserved stage 7 stem cell (HUES8 cell line)-derived islets. Details about stem cell differentiation and sequencing can be found on the publication by Rajaei et al. (2025, Science Translational Medicine). This dataset correspond to Fig 4 of the publication.

  Dataset EGAD50000001396

• HiChIP for 2 samples

  This dataset contains H3K27ac HiChIP data from ta primary sample and a patient derived model (PDX) of the novel FOXF1/FENDRR ALL subtype. All the 2 samples are in bam file type.

  Dataset EGAD50000001787

• Patient-derived organoids cohort raw FASTQ from SGMedical

  Raw FASTQ files for a glioblastoma multiforme organoid study, including exome sequencing and RNA-seq. 29 runs (paired-end), 58 FASTQ.c4gh files (R1/R2). Short-read Illumina; library strategies include exome capture and stranded total RNA-seq (see Experiment records for kit/instrument details). No processed results are included; access is controlled under the selected Policy.

  Dataset EGAD50000001741

• Whole genome sequencing of circulating cell-free DNA on Illumina and Ultima platforms

  The dataset includes Illumina (n=1) and Ultima (n=92) sequencing of circulating cell-free DNA. The dataset was generated through standard whole genome sequencing (Illumina n=1 & Ultima n = 15) and using a duplex unique molecular identifier whole genome sequencing workflow (Ultima, n=77). This dataset includes cancer samples and cancer-free control samples.

  Dataset EGAD50000001234

• A non-canonical lymphoblast in refractory childhood T-cell leukaemia

  Single cell mRNAseq of T-ALL samples including presentation samples for 13 with refractory disease and 8 with responsive disease, and Day 28 samples for 8 patients with refractory disease. Also includes bulk mRNA sequencing on 6 of the patients with responsive disease.

  Dataset EGAD50000001128