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• Small‑scale mutations are infrequent as mechanisms of resistance in post‑PARP inhibitor tumour samples in high grade serous ovarian cancer

  These are 28 targeted exome sequencing fastq files (tumour and germline) generated from ovarian cancer samples which had been exposed to PARP inhibitors, for the described project.

  Dataset EGAD50000000206

• LCM isolated buccal epithelial cell WGS of chimeric twins

  Buccal epithelial cells of chimeric twins were isolated using laser-capture microdissection. Cells were pooled (13-60 cells) per batch to create a genomic DNA library using an NEB low-input kit.

  Dataset EGAD50000000131

• Sensitive circulating tumor DNA based residual disease detection in epithelial ovarian cancer

  We analyzed 264 plasma samples collected between June 2016 and September 2021 from 63 epithelial ovarian cancer patients using tumor-guided plasma cell-free DNA analysis to detect residual disease after treatment.

  Dataset EGAD50000000360

• COLONOMICS Whole Exome Sequencing

  This dataset consists of Illumina HiSeq 2000 Whole Exome Sequencing of 84 colorectal samples: 42 Tumor tissue samples and 42 Normal tissue samples (adjacent to tumor sites). 2x75bp paired-end sequencing reads: 2 fastq files per sample

  Dataset EGAD00001004826

• Clean sequence of LUAD in young never-smoker

  we conducted whole genome sequencing (WGS) to characterize the genomic alterations of 36 never-smoker Chinese patients with lung adenocarcinomas (LUADs). This dataset is containing clean fastq files of 36 never-smoker Chinese patients with lung adenocarcinomas (LUADs)

  Dataset EGAD00001003890

• Signatures of mismatch repair deficiency in cancer genomes

  DNA replication errors occurring in mismatch repair (MMR) deficient cells persist as mismatch mutations and predispose to a range of tumors. Here, we sequenced the first whole-genomes from MMR-deficient endometrial tumors.

  Dataset EGAD00001000641

• scRNAseq of T-cells from two responders to high-dose ipilimumab

  ScRNAseq of CD3 T-cells isolated from post-treatment bladder tissue from 2 samples from the NABUCCO 1 trial. Paired-end RNAsequencing was used on the Illumina NovaSeq 6000 sequencing platform.

  Dataset EGAD50000002557

• Identification of drug resistance genes in melanoma by Exome Sequencing

  The cell lines in this study are a combination of internally sequenced (cosmic) and externally sequenced cell lines known to be “double-wild-type” (lacking BRAF and NRAS somatic mutations). These sequences were realigned in this data set for consistency.

  Dataset EGAD00001003260

• low-pass WGS and 48 cancer gene exon sequencing of COCOS growth

  55 single read fastq files of low-pass WGS sequencing used to determine copy number aberrations and 34 paired read fastq files of 48 cancer gene exon sequencing

  Dataset EGAD00001004427

• WGS of HSPCs and MSCs

  Whole genome sequencing data of organoid cultures derived from human bone marrow-derived and cord blood-derived hematopoietic stem and multipotent progenitor cells to study the mutation accumulation.

  Dataset EGAD00001004451