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• GoNL release 5 haplotype panel

  The samples in this panel come from 250 families: 248 parents-child trios and 2 parent-child duos. As the children do not provide additional haplotypes or population information, they were excluded from the panel. The samples present in the release are composed of 248 couples, 2 single individuals and 1 sample composed from the 2 haplotypes from the duo's children transmitted by their missing parent. The composed sample is named gonl-220c_223c.The files contain a total of 18.9M SNVs and 1.1M INDELs in autosomal chromosomes. They were generated by phasing/imputing the SNVs (a) and INDELs (b) using MVNCall. Only sites passing filters are reported. Sites filtered as part of the GoNL inaccessible genome were kept (but flagged as filtered) and still may contain true positive calls but should be used with care as they are located in parts of the genome that are less well captured (systematic under or over-covered or low-mapping quality)

  Dataset EGAD00001000744

• Single-Cell Analysis of CD19-Specific CAR T Cell Treatment of Relapsed/Refractory CD19+ Acute Lymphoblastic Leukemia

  By leveraging single-cell transcriptome and T cell receptor (TCR) sequencing, we aimed to track the transcriptional signatures of chimeric antigen receptor (CAR) T cell clonotypes throughout the course of treatment and furthermore identify molecular patterns leading to potent CAR T cell cytotoxicity. The data presented in this study encompass blood and bone marrow samples from patients ≤ 21 years of age with relapsed or refractory B-cell acute lymphoblastic leukemia (B-ALL) participating in the SJCAR19 phase I/II clinical trial (NCT03573700). In brief, patients enrolled in the clinical trial received either 1 x 10^6 (dose level 1) or 3 x 10^6 (dose level 2) per kilogram of body weight following successful generation of autologous CAR T cell products and lymphodepleting chemotherapy. Peripheral blood was drawn from each participant every week until week 4 post-infusion, at week 6 or 8, and month 3 or 6 if feasible. At week 4 post-infusion, blood marrow was also collected from participants. Total T cells (CD3+) were sorted from each post-infusion sample, as well as the pre-infusion CAR T cell products, and processed through 10x Genomics’ single-cell gene expression and V(D)J sequencing platform using the standard protocol. We identified a unique and unexpected transcriptional signature in a subset of pre-infusion CAR T cells that shared TCRs with post-infusion cytotoxic effector CAR T cells. Functional validation of cells with even a subset of these pre-effector markers demonstrated their immediate cytotoxic potential and resistance to exhaustion. The data deposited into dbGaP include all raw single-cell expression and V(D)J sequencing generated from samples obtained from 16 study participants.

  Study phs002966

• CD3 bispecific antibody-induced cytokine release is dispensable for cytotoxic T cell activity

  Study EGAS00001003734

• Data Access Committee for the UCSF Chordoid Glioma of the Third Ventricle Genome Project Dataset

  Dac EGAC00001000776

• Data access committee handling data access requests for biomarker data from the clinical trial IMmotion150.

  Dac EGAC00001000946

• Data access policy for PDTX Breast Cancer RNA-seq data from Ros et al (2020)

  Dac EGAC00001001620

• DAC for "Detection of Gene Fusions using Targeted Next-Generation Sequencing – a Comparative Evaluation"

  Dac EGAC00001001905

• Data Access Committee for study Genetics of Preeclampsia at High Altitudes

  Dac EGAC00001002097

• EGAD00000000027

  eQTL data for European newborns

  Dataset EGAD00000000027

• EGAD00010000052

  Monozygotic twins that are discordant for schizophrenia (Genotyping)

  Dataset EGAD00010000052

• HC_genotyping

  HC genotyping data for lead SNPs using Illuminia Global Array V2.0

  Dataset EGAD00010002475

• DAC for YCC Sarcoma

  Access can be granted by contacting Hyo Song Kim (hyosong77@yuhs.ac).

  Dac EGAC50000000046

• DAC Endoresist

  Data access committee for the Endoresist project of panel sequencing: Professor Johan Hartman

  Dac EGAC50000000174

• Circulating tumor cells for comprehensive and multiregional non-invasive genetic characterization of multiple myeloma

  Study EGAS00001004288

• A method for multiplexed full-length single-molecule sequencing of the human mitochondrial genome

  Study EGAS00001006280

• CReATe Fertility Centre DAC

  DAC for the management of dataset own by CReATe Fertility Centre.

  Dac EGAC50000000646

• Human glioblastoma single cell DAC (Linnarsson)

  DAC for human glioblastoma single cell sequencing samples

  Dac EGAC50000000575

• Human developing meninges single cell DAC (Linnarsson)

  DAC for human developing meninges single cell sequencing

  Dac EGAC50000000576

• Asan Medical Center Data Access Committee

  Asan Medical Center Data Access Committee for BRISK study.

  Dac EGAC50000000733

• Hepatocellular Carcinoma Spatial transcriptomics Data Access Committee

  This is the DAC for study ST HCC

  Dac EGAC50000000635

• Pan Prostate Cancer Group Data Access Control Committee

  DACC for the PanProstate Cancer Group projects

  Dac EGAC50000000602

• GenomeWideData_for_Present_Day_Peruvian_individuals_living_in_urban_areas

  Genome-wide data for 432 Admixed individuals from Peru

  Dataset EGAD00010002795

• DAC SysMed

  Data access control for datasets submitted by SysMed

  Dac EGAC50000000089

• MOSAIC Window DAC

  Data Access Committee for the MOSAIC Window initiative.

  Dac EGAC50000000398

• DAC for Genetic and Microenvironmental Analysis of PTCL at Department of Hematology, University of Tsukuba

  Dac EGAC50000000600