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Genetic landscape of pediatric Adrenocortical Tumor

Paediatric adrenocortical carcinoma is a rare malignancy with poor prognosis. Here we analyse 37 adrenocortical tumours (ACTs) by whole-genome, whole-exome and/or transcriptome sequencing. Collectively, these findings demonstrate the nature, timing and potential prognostic significance of key genetic alterations in paediatric ACT and outline a hypothetical model of paediatric adrenocortical tumorigenesis.

Click on a Dataset ID in the table below to learn more, and to find out who to contact about access to these data

Dataset ID Description Technology Samples
EGAD00001000160 Illumina HiSeq 2000 16
EGAD00001001432 Illumina HiSeq 2000 1337
EGAD00001001433 Illumina HiSeq 2000 906
EGAD00001001874 Illumina HiSeq 2000 16
EGAD00001002679 Illumina HiSeq 2000 38
EGAD00001002680 Illumina HiSeq 2000 26
Publications Citations
Assessing telomeric DNA content in pediatric cancers using whole-genome sequencing data.
Genome Biol 13: 2012 R113
The Childhood Solid Tumor Network: A new resource for the developmental biology and oncology research communities.
Dev Biol 411: 2016 287-293
XAF1 as a modifier of p53 function and cancer susceptibility.
Sci Adv 6: 2020 eaba3231
The landscape of coding RNA editing events in pediatric cancer.
BMC Cancer 21: 2021 1233
Germline TP53 mutations undergo copy number gain years prior to tumor diagnosis.
Nat Commun 14: 2023 77
Comprehensive analysis of mutational signatures reveals distinct patterns and molecular processes across 27 pediatric cancers.
Nat Cancer 4: 2023 276-289