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Longitudinal bulk B- and T-cell receptor repertoire sequencing from the DNG2002 dengue virus 3 human challenge study

Longitudinal bulk B- and T-cell receptor repertoire sequencing data generated from participants enrolled in the DNG2002 dengue virus 3 human challenge study. The dataset comprises UMI-based AIRR-seq libraries generated from longitudinal whole-blood samples collected before and after controlled DENV-3 infection. It includes raw sequencing reads and processed immune-repertoire data for immunoglobulin heavy-chain and T-cell receptor libraries. The data support analyses of repertoire composition, clonal dynamics, molecular complexity, sequencing depth, and host adaptive immune responses over the course of infection. The dataset is intended to support both methodological studies of AIRR-seq and biological analyses of the longitudinal immune response to controlled DENV-3 infection.

Type: Transcriptome Sequencing
Archive: European Genome-phenome Archive (EGA)

3 Datasets

Click on a Dataset ID in the table below to learn more, and to find out who to contact about access to these data

Dataset ID	Description	Technology	Samples
EGAD50000003144	This dataset contains raw paired-end FASTQ files of bulk BCR/TCR adaptive immune receptor repertoire sequencing data from longitudinal whole-blood RNA samples collected during a controlled primary DENV3 human challenge study.	Element AVITI	138
EGAD50000003145	This dataset contains assembled bulk TCR adaptive immune receptor repertoires from longitudinal whole-blood RNA samples collected during a controlled primary DENV3 human challenge study. The data support analysis of TCR clonal expansion, and convergent receptor responses after dengue infection.	Element AVITI	138
EGAD50000003146	This dataset contains assembled bulk BCR/IGH adaptive immune receptor repertoires from longitudinal whole-blood RNA samples collected during a controlled primary DENV3 human challenge study. The data support analysis of BCR clonal expansion, isotype usage, somatic hypermutation, and convergent antibody responses after dengue infection.	Element AVITI	138