14476 results for "PLOS+ONE+Pennsylvania+German+ACS+language+code+pdc+open+access+study"

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• VIB CCB Translational Genetics Data Access Committee

  Dac EGAC00001003415

• IRIBHM computational biology data access committee

  Dac EGAC00001003436

• Data Access Committee for data from EGAS00001007708

  Dac EGAC00001003486

• Singapore Gastric Cancer Consortium Data Access Committee

  Dac EGAC00001002251

• DAC_ICARUS_BREAST01

  Data access committee for ICARUS BREAST 01

  Dac EGAC50000000344

• Genome Asia 100K Consortium

  Dac EGAC00001001439

• Department of Gastroenterology and Hepatology Data Access Committee

  Dac EGAC00001003021

• HaikaLab Immuno-Oncology research group Data Access Committee

  Dac EGAC50000000387

• Data Access Committee for data from EGAS00001007484

  Dac EGAC00001003459

• Walter and Eliza Hall Institute Research Data Access Committee

  Dac EGAC00001003583

• WES of adult intellectual disabilities with co-morbid psychiatric disorders (2019-08-07)

  ost adults with intellectual disabilities (ID) do not undergo genetic diagnostic investigation as part of their clinical care and have 'missed the boat' with regard to the WES and WGS genetic testing that is now being provided for children with ID. There is a dramatically increased risk of psychistric disorders in adults with ID, e.g. the risk of psychoses is 10X higher than in the general population. It remains an open question as to how much of adult ID is genetic in origin and how similar the genetic forms of adult ID are to those being diagnosed in children, in part due to survivor bias. There is also the opportunity to identify adults with treatable forms of ID, of which over 80 have been described, thus improving their clinical management. Furthermore, analysis of medical records of adults with genetic forms of ID can help to characterise the 'natural history' of individual disorders, resulting in more accurate prognoses for diagnosed children and identifying opportunities for improved management and possibly therapeutic intervention (e.g. optimal anti-epileptic therapy). Here we propose to exome sequence (to ~50X coverage) 200 adults with ID and co-morbid psychiatric disorders. This cohort has previously been assayed with chromosomal microarrays (Wolfe et al 2017 EJHG, 25, 66-72) identifying a diagnostic yield of ~11% which is comparable to the CNV diagnostic yield in various child ID cohorts (10-15%). The authors observed no substantive biases in diagnostic yield between different psychiatric diagnostic classes. The WES data will be analysed using the diagnostic workflows developed in the DDD study to ensure comparability between child and adult ID datasets. This study is intended as a pilot study to demonstrate the value of WES in adults with ID. This data is part of a pre-publication release. For information on the proper use of pre-publication data shared by the Wellcome Trust Sanger Institute (including details of any publication moratoria), please see http://www.sanger.ac.uk/datasharing/ . This dataset contains all the data available for this study on 2019-08-07.

  Dataset EGAD00001005236

• RNA-seq of granulosa cells from 8 IVF patients in two age groups

  This dataset contains raw sequencing data of mRNA from granulosa cell samples from 8 human patients undergoing in vitro fertilization. All patients were normal responders referred for male infertility and were grouped into two age groups (younger than 31 or older than 38 years old). Each sample contains all granulosa cells collected from one patient on one collection date. Raw sequencing fastq files are available in this dataset, count tables are available in ArrayExpress (E-MTAB-13496).

  Dataset EGAD50000001210

• 10X single cell sequencing of HNT34 cocultured with Tcells with or without antibody targeting SLAMF6

  This dataset contains fastq-files from single cell 5' RNA sequencing of the AML cell line HNT34 and normal T cells following co-culture with and without an antibody blocking SLAMF6 (TNC-1). The libraries were prepared using 10X GEM-X Universal 5' Gene Expression v3 Reagent Kit. In total, the dataset contains sequenced gene expression libraries from four samples (HNT34 co-cultured with T cells from two different donors; for both donors there is one sample with and one sample without the blocking antibody).

  Dataset EGAD50000001573

• TK-EPN862 - Patient-derived xenograft model of Posterior Fossa A Ependymoma - RNAseq

  In Vivo Loss of Tumorigenicity in a Patient-Derived Orthotopic Xenograft Mouse Model of Ependymoma. Whitehouse et al. 2023 Frontiers in Oncology. We describe the establishment of a patient-derived orthotopic xenograft (PDOX) model of posterior fossa A (PFA) EPN, derived from a metastatic cranial lesion. Patient and PDOX tumors were analyzed using RNA sequencing. RNAseq data (paired end) provided here correspond to Primary tumour, two metastatic lesions (one spinal, one cranial), and a patient-derived xenograft derived from the patient.

  Dataset EGAD00001009870

• LUD2015-005 Trial Data Access Committee

  Dac EGAC00001002863

• THE NOWAC BLOOD-BREAST CANCER COMMITEE DATA ACCESS AGREEMENT

  Dac EGAC00001000743

• Board considering access to van Hijfte snRNA-seq GBM dataset

  Dac EGAC00001003044

• Genomics of MPNST (GeM) Consortium Data Access Committee

  Dac EGAC00001002563

• Thirant et al Nature Communications 2023 Data Access Commitee

  Dac EGAC00001003192

• European Network of Genomic and Genetic Epidemiology Data Access Committee

  Dac EGAC00000000008

• "Data Access Center Cancer Genomics Group"

  Dac EGAC00001000030

• Cancer Genome Database Data Access Committee (CGDB_DAC)

  Dac EGAC00001000033

• Signal Transduction Team ICR (2011) Data Access Committee

  Dac EGAC00001000040

• UPF - Evolutionary Population Genetics lab Data Access Committee

  Dac EGAC00001000244

• MS-Twin Data Access Committee

  Dac EGAC00001000331