Search Results - EGA European Genome-Phenome Archive

cfDNA analysis reveals relation of POLR1D amplification to bevacizumab resistance in colorectal cancer patients

Bevacizumab is an approved anti-angiogenic drug for patients with metastasized colorectal cancer (mCRC) targeting VEGF. The survival benefit of anti-VEGF therapy in mCRC patients is limited to a few months and acquired resistance mechanisms are greatly unknown. Using plasma DNA, we studied the evolution of tumor genomes in a cohort of patients with mCRC (n=150) and observed a recurrent focal amplification (8.7% of cases) on chromosome 13q12.2. Analysis of TCGA data (n=619) suggested an association with later stages, which we confirmed by longitudinal plasma analyses. We defined the minimally amplified region and studied the mechanistic consequences of copy number gain of the involved genes. The amplification of one gene, POLR1D, impacted cell proliferation, resulting in upregulation of VEGFA, an important regulator of angiogenesis which has been implicated in the resistance to bevacizumab. In several patients, we observed the emergence of this 13q12.2 amplicon under bevacizumab treatment, which was invariably associated with evolution of therapy resistance. Hence, we describe a novel resistance mechanism against a widely applied treatment in mCRC patients which will impact clinical management .

Dataset EGAD00001005761

7825 results for "canc*"

in 39.44 milliseconds.

cfDNA analysis reveals relation of POLR1D amplification to bevacizumab resistance in colorectal cancer patients

Genome and transcriptome sequence data from a pancreatic cancer patient

Genome and transcriptome sequence data from a metastatic pancreatic neuroendocrine tumor patient

Exome and Transcriptome for gastric cancer gene-drug analysis

Genome and transcriptome sequence data from a pancreatic ductal adenocarcinoma patient

Genome and transcriptome sequence data from a pancreatic cancer patient

Genome and transcriptome sequence data from a cervical adenocarcinoma patient

Genome and transcriptome sequence data from a sex-cord stromal tumor patient

Genome and transcriptome sequence data from a pancreatic adenocarcinoma patient

Genome and transcriptome sequence data from an endometrioid ovary carcinoma patient

Genome and transcriptome sequence data from a metastatic breast cancer patient

Genome and transcriptome sequence data from a pancreatic cancer patient

Genome and transcriptome sequence data from a pancreatic cancer patient

Genome and transcriptome sequence data from a pancreatic cancer patient

Genome and transcriptome sequence data from a pancreatic cancer patient

Genome and transcriptome sequence data from a tongue squamous cell carcinoma (h&n) patient

Genome and transcriptome sequence data from a neuroendocrine tumor (gic) patient

Genome and transcriptome sequence data from a pancreatic cancer patient

Genome and transcriptome sequence data from a pancreatic cancer patient

Genome and transcriptome sequence data from a transformed diffuse large B cell lymphoma patient

Genome and transcriptome sequence data from an osteosarcoma patient

Genome and transcriptome sequence data from a chordoma patient

Genome and transcriptome sequence data from a cervical squamous cell carcinoma patient

Genome and transcriptome sequence data from a colorectal cancer patient

Genome and transcriptome sequence data from a metastatic breast cancer patient

7825 results for "canc*"

in 39.44 milliseconds.

cfDNA analysis reveals relation of POLR1D amplification to bevacizumab resistance in colorectal cancer patients

Genome and transcriptome sequence data from a pancreatic cancer patient

Genome and transcriptome sequence data from a metastatic pancreatic neuroendocrine tumor patient

Exome and Transcriptome for gastric cancer gene-drug analysis

Genome and transcriptome sequence data from a pancreatic ductal adenocarcinoma patient

Genome and transcriptome sequence data from a pancreatic cancer patient

Genome and transcriptome sequence data from a cervical adenocarcinoma patient

Genome and transcriptome sequence data from a sex-cord stromal tumor patient

Genome and transcriptome sequence data from a pancreatic adenocarcinoma patient

Genome and transcriptome sequence data from an endometrioid ovary carcinoma patient

Genome and transcriptome sequence data from a metastatic breast cancer patient

Genome and transcriptome sequence data from a pancreatic cancer patient

Genome and transcriptome sequence data from a pancreatic cancer patient

Genome and transcriptome sequence data from a pancreatic cancer patient

Genome and transcriptome sequence data from a pancreatic cancer patient

Genome and transcriptome sequence data from a tongue squamous cell carcinoma (h&amp;n) patient

Genome and transcriptome sequence data from a neuroendocrine tumor (gic) patient

Genome and transcriptome sequence data from a pancreatic cancer patient

Genome and transcriptome sequence data from a pancreatic cancer patient

Genome and transcriptome sequence data from a transformed diffuse large B cell lymphoma patient

Genome and transcriptome sequence data from an osteosarcoma patient

Genome and transcriptome sequence data from a chordoma patient

Genome and transcriptome sequence data from a cervical squamous cell carcinoma patient

Genome and transcriptome sequence data from a colorectal cancer patient

Genome and transcriptome sequence data from a metastatic breast cancer patient

Genome and transcriptome sequence data from a tongue squamous cell carcinoma (h&n) patient