8215 results for "canc*"

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• MethylScan data from plasma

  Raw data (fastq files) from 1061 plasma samples profiled with the MethylScan assay, a highly cost-effective approach for cfDNA methylome sequencing. MethylScan is a cost-efficient cfDNA methylome sequencing method that enriches methylation-informative fragments while actively depleting abundant background DNA derived from blood cells. By reducing this background noise, it improves the detection sensitivity for disease-associated cfDNA, such as tumor-derived DNA.The plasma samples (n = 1,061) were from 460 cancer patients (covering 4 major cancers: liver, lung, ovarian, and stomach cancer) and 601 noncancer individuals. The noncancer individuals (n = 601) can be further categorized into three groups: noncancer patients at high-risk of liver cancer who have chronic liver diseases (n = 157), noncancer patients at high-risk of lung cancer who have benign lung nodules (n = 43), and general noncancer hospital visitors (n = 401).

  Dataset EGAD00001015686

• Genomic and Functional Profiling of Acral Melanoma from the admixed Brazilian Population Reveals Disease Drivers and Targetable Vulnerabilities

  Acral melanoma, a subtype of melanoma characterized by its occurrence on palms, soles, and beneath the nails, presents unique challenges in diagnosis and treatment due to its distinct genetic and environmental factors. Despite recent advancements in targeted therapies for melanoma, the efficacy of treatments in acral melanoma remains limited, emphasizing the urgent need for a deeper understanding of its genetic landscape. CRISPR-based functional genomics screening has emerged as a powerful tool for uncovering genetic dependencies and potential therapeutic targets in various cancers. In this project, we present the results of CRISPR screening performed on acral melanoma cell lines to identify genes essential for cell survival and proliferation collectively termed “fitness". Through this screening approach, we aim to elucidate the molecular mechanisms underlying the pathogenesis of acral melanoma and identify novel therapeutic vulnerabilities. Our findings reveal key genetic drivers and pathways implicated in acral melanoma progression, offering potential targets for the development of precision therapies tailored to this aggressive subtype of melanoma

  Dataset EGAD00001015690

• Dataset for "CutNRun" sequencing of 12 samples of patients with colorectal cancer

  This dataset contains 12 "CutNRun" sequencing samples of patients with colorectal cancer. The sequencing was performed on Illumina NextSeq 550 using Cell Signaling TechnologyDNA Library Prep _Kit for Illumina Systems. The sequencing was always paired.

  Dataset EGAD00001015694

• Aneuploidy in Pancreatic Cancer

  WGS of pancreatic lesions

  Dataset EGAD00001015734

• Genome and transcriptome sequence data from a metastatic colon cancer patient

  Genome and transcriptome sequence data from a metastatic colon cancer patient,generated as part of the BC Cancer Agency's Personalized OncoGenomics (POG) study

  Dataset EGAD00001015976

• Genome and transcriptome sequence data from a metastatic neuroendocrine carcinoma of unknown primary patient

  Genome and transcriptome sequence data from a metastatic neuroendocrine carcinoma of unknown primary patient,generated as part of the BC Cancer Agency's Personalized OncoGenomics (POG) study

  Dataset EGAD00001015977

• Genome and transcriptome sequence data from a radiation induced sarcoma patient

  Genome and transcriptome sequence data from a radiation induced sarcoma patient,generated as part of the BC Cancer Agency's Personalized OncoGenomics (POG) study

  Dataset EGAD00001015978

• Genome and transcriptome sequence data from a dedifferentiated uterine leiomyosarcoma patient

  Genome and transcriptome sequence data from a dedifferentiated uterine leiomyosarcoma patient,generated as part of the BC Cancer Agency's Personalized OncoGenomics (POG) study

  Dataset EGAD00001015979

• Genome and transcriptome sequence data from a poorly differentiated lung adenocarcinoma patient

  Genome and transcriptome sequence data from a poorly differentiated lung adenocarcinoma patient,generated as part of the BC Cancer Agency's Personalized OncoGenomics (POG) study

  Dataset EGAD00001015980

• Genome and transcriptome sequence data from a colon cancer patient

  Genome and transcriptome sequence data from a colon cancer patient,generated as part of the BC Cancer Agency's Personalized OncoGenomics (POG) study

  Dataset EGAD00001015981