DNA from patients with otosclerosis will be subjected to exome sequencing
Whole Exome Sequencing of Permanent Neonatal Diabetes Patients
Single case of T-ALL carrying t(4;6), a novel translocation.
Sequencing data of human SHH medulloblastoma samples
Total RNAseq data from 47 patients with NMIBC.
scRNA-seq samples from healthy and asthma donors part 1.
SOMAscan plasma proteome datasets generated from participants consuming the fiber blend snack prototype (study 2)
SOMAscan plasma proteome datasets generated from participants consuming the pea fibre snack prototype (study 1)
This is the affymetrix gene expression data of the metastatic tumours related to this study.
ATAC-seq data from multiple colorectal cancer cell lines
Whole-Exome-Sequencing of 5 pooled patients for SNP-based demultiplexing
new 70 germline WGS data of prostate cancer patients
Next Generation Sequencing data from Biliary Tract cancers
Construction of the KIR variant imputation panel in the Japanese population
Stage-1 meta-analysis with GC correction
Matrix of gene x sample RNAseq read count data.
SNP array data of 31 Matched cancer/PNE samples
High-resolution analysis for urinary DNA jagged ends
The Long Life Family Study (LLFS) is an international collaborative study of the genetics and familial components of exceptional survival, longevity, and healthy aging. Families were recruited through elderly probands (generally in their 90s) who self-reported on the survival history of their parents and siblings, and on the basis of this information, families which showed clustering of exceptional survival were recruited. [Specifically, a Family Longevity Selection Score (FLOSS) ≥7 was required. The FLOSS measures the average excess Observed lifespan over that Expected based upon lifetables, while adding a bonus term for still-living individuals. Thus FLOSS is a useful tool for scoring and selecting families for inclusion in a research study of exceptional survival (Sebastiani et al., 2009, PMID: 19910380)]. Probands resided in the catchment areas of four Field Centers (Boston University, Columbia University, University of Pittsburgh, and University of Southern Denmark). Recruited family members were phenotyped through extensive in-home visits by teams of technicians who traveled all over the USA and Denmark. Blood assays were centrally processed at a Laboratory Core (University of Minnesota) and protocols were standardized, monitored and coordinated through a Data Management Coordinating Center (Washington University). We examined and extensively phenotyped in all major domains of healthy aging, 4,953 individuals in 539 families through comprehensive in-home visits. Of these, 4,815 gave dbGaP sharing permission and had sufficient quantity/quality of DNA for GWAS genotyping. This large collection of families, selected on the basis of clustering for exceptional survival, is a unique resource for the study of human longevity and healthy aging. We estimate that less than 1% of the Framingham Heart Study (FHS) families (a roughly random population family sample) would meet the minimal entrance criteria for exceptional survival required in the LLFS (Sebastiani et al., 2009, PMID: 19910380). Thus, the least exceptional LLFS families show more clustering for exceptional longevity than 99% of the FHS families. Although the LLFS pedigrees were selected on the basis of longevity per se in the upper generation (and the generation above that), the children's generation have significantly lower rates of many major diseases and have better healthy aging profiles for many disease phenotypes (Newman et al., 2011, PMID: 21258136). The participants had their first in-person visit between 2006 and 2009. After that visit, they were contacted annually by telephone to update vital status, medical history, and general health. Between 2014 and 2017, willing participants completed a second in-person visit. The second visit followed the same protocols and centralized training as the first visit. During the second visit, a portable carotid ultrasound exam was added. Again, participants were continuously contacted annually for telephone follow-up during the period of the second in-person visit and after that. Annual telephone follow-ups currently ongoing, and plans for a third in-person visit are in progress.
