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• DAC Dr. PORTEU – Gustave Roussy

  Targeting Heterochromatin Eliminates Malignant Stem Cells in Chronic Myelomonocytic Leukemia Through Reactivation of Retroelements and Innate Immune pathways Data Access Committee Members (Name, Email, Job Title): Principal Investigator PORTEU Françoise (FRANCOISE.PORTEU@gustaveroussy.fr) Head of Bioinformatics platform DELOGER Marc (Marc.DELOGER@gustaveroussy.fr) Data Protection Officer BECHET Clara (Clara.BECHET@gustaveroussy.fr)

  Dac EGAC50000000252

• WGS data of 100 Breast Cancer patients from SV Based ctDNA Detection study

  Whole Genome Sequencing data of 100 Breast Cancer patients from "Ultrasensitive Detection and Monitoring of Circulating Tumor DNA using Structural Variants in Early-Stage Breast Cancer" study.

  Dataset EGAD50000001175

• Methylome and transcriptome of memory B cells - Autoproliferation

  Methylome and the corresponding transcriptome of autoproliferating/Dim B cells and resting/hi B cells in Multiple sclerosis patients

  Dataset EGAD50000001236

• Short-read RNA-seq of doxycycline-inducible DUX4 human myoblast cell lines

  The dataset includes the short-read RNA sequencing data of DUX4i myoblasts (Clone-5 and Clone-7) with and without 16-hour DOX-treatment (n=1 in each condition).

  Dataset EGAD50000000719

• Tumor mutational landscape in individuals with CMMRD

  Whole exome sequencing data from the tumors (n=16) of individuals with constitutional mismatch repair deficiency. Data was aligned to GRCh38.

  Study EGAS50000000081

• bulk RNAseq from metastatic uveal melanoma tumour biopsies

  Tumour biopsies were obtained from uveal melanoma patients (n = 35) pre and 16 days post treatment with tebentafusp. Biopsies, which were either snap frozen or put in RNA later, were analysed by bulk RNA sequencing (50 million reads per sample) using the Illumina NovaSeq system.

  Dac EGAC50000000519

• RNA-seq in endometrial healthy and tumor tissues

  RNA has been extracted by Rneasy mini kit from around 30mg of flash frozen tissue derived from 3 healthy and 3 tumor endometrial tissues of post-menopausal patients. Raw paired-end fastq.gz files are provided.

  Dataset EGAD50000000200

• Whole genome sequencing data of cfDNA and WBC from 5 patients with mUC

  Whole genome Illunima sequencing of cfDNA of 5 metastatic urothelial carcinoma patients. White blood cell (WBC) samples are used as patient matched germline samples (n=5). All files are in paired-end fastq format.

  Dataset EGAD50000001570

• DNA methylation and transposable element landscapes in human regulatory and conventional Tcells

  Whole genome bisulfate sequencing using tagmentation of Tcells from skin and blood.The method improved TWGBS protocol (Weichenhan et al.), Methods Mol. Biol. 2018, vol. 1708 pp.105-122) was used

  Dataset EGAD50000001022

• Whole-exome-sequencing in Motor neuron disease (MND)

  To identify the genetic cause and modifiers of Motor neuron disease (MND), we performed Whole-exome-sequencing of Motor neuron disease (MND) patients.

  Study JGAS000422

• Whole-genome-sequencing and Whole-exome-sequencing in Myopathy

  To identify the genetic cause and modifiers of Myopathy, we performed Whole-genome-sequencing and Whole-exome-sequencing of Myopathy patients.

  Study JGAS000365

• Whole-exome-sequencing in Charcot-Marie-Tooth disease (CMT)

  To identify the genetic cause and modifiers of Charcot-Marie-Tooth disease (CMT), we performed Whole-exome-sequencing of CMT patients.

  Study JGAS000337

• Multi-modal spatial characterization of tumor-immune microenvironments identifies targetable inflammatory niches in diffuse large B-cell lymphoma

  This dataset includes NGS data of large B-cell lymphoma, including bulk RNAseq data of 71 biopsies and germline WES data of 70 biopsies.

  Dataset EGAD50000001641

• Microarray CDX or EDX from primary tumor and metastasis

  expression analysis of FACS sorted human cells from primary tumors and distant organs micrometastases in xenografts. Patient Derived xenografts were generated transplanting tumor cells from metastatic breast cancer patients into mammary fat pad of immunocompromised mice

  Dataset EGAD00010002711

• Two scRNA-seq datasets from control and irradiated organoids.

  Dataset includes two scRNA-seq samples from control and irradiated organoids. Files included in the dataset are Fastq files. Sample libraries produced with Chromium X were sequenced on an Illumina NovaSeq 6000 sequencer.

  Dataset EGAD50000001933

• CFTR Gene Variant Detection in Moroccan Individuals via Nanopore Long-Read Sequencing

  This study consists of sequencing the whole CFTR gene (coding and non-coding regions) using Oxford Nanopore on Moroccan CF patients

  Study EGAS50000001423

• WES sequencing of metastatic colorectal cancer patient-derived xenografts with known response to irinotecan

  Whole exome sequencing of patient-derived xenograft (PDX) models from NOD/SCID mice without treatment. These PDX are obtained from tumors from patients with metastatic colorectal cancer after serial passaging in mice.

  Dataset EGAD50000002137

• Single-cell multidimensional profiling of tumor cell heterogeneity in supratentorial ependymomas

  55 Supratentorial Ependymomas patient samples were sequenced scRNA-sequencing using Smart-Seq2 and 10x protocol (51 samples) and 10x Genomics protocol (4 samples) on a NextSeq 550 sequencer (Illumina).

  Dataset EGAD50000002186

• Multi-omics characterisation of the response to stimulation in Long Covid patients

  We stimulated immune cells of 15 patients (5 timepoints) with Long Covid with RPMI or P. Aeruginosa strains (4h stimulations).

  Study EGAS50000000143

• WGS of cfDNA in PDAC Breast Cancer and Matched Controls

  This dataset contains WGS data derived from plasma cfDNA. The cohort includes PDAC and breast cancer patients alongside matched controls. These data are intended to support research into ctDNA and genomic fragmentation patterns.

  Dataset EGAD50000002323

• Fungal infection in neural tissue from Amyotrophic Lateral Sclerosis

  The study shows that fungus infection, isolated from neural tissue, can be a risk factor to develop Amyothophic lateral sclerosis (ALS).

  Study EGAS00001002473

• Phased melanoma whole genomes

  We have sequenced whole genomes of 10 melanoma samples (1 cell line; A375 and 9 patient derived short term cultures). Libraries were prepared with 10X linked reads technology in order to obtain phase information and subsequently sequenced on Illumina NovaSeq6000.

  Dataset EGAD00001005773

• Landscape and significance of multiple mutations in oncogenes.

  This study is a comprehensive pan-cancer study of oncogenic multiple mutations (MMs) which includes long-read whole-genome sequencing data (n = 3).

  Study EGAS00001003763

• WES of multi-regional CRC samples

  BAM files of Whole Exome Sequencing (WES) experiment on multi-regional colorectal cancer (CRC) samples. 32 tumour and 16 normal samples corresponding to 16 patients were sequenced, which makes 32 tumour BAMs and 16 normal BAMs (48 BAMs in total).

  Dataset EGAD00001006165

• DKFZ-St.Jude Medulloblastoma - 3 XI046 SF controls, WGS data

  3 control whole genomes, SF cohort, sequenced on Illumina machines from the paper "Germline Elongator mutations in Sonic Hedgehog medulloblastoma" (Waszak et al. 2020 Nature).

  Dataset EGAD00001006662