ICGC Oesophageal adenocarcinoma - Barrett's samples

Study ID Alternative Stable ID Type
EGAS00001000726 Other

Study Description

The oesophageal project will focus on adenocarcinoma which is increasing in incidence in the UK and other developed countries and has a very poor outcome. The primary aims of this project are to deeply sequence tumour and normal genomic DNA (including the precursor condition Barrett’s oesophagus when material is available) to provide a comprehensive catalogue of somatic mutations. This will be achieved through a UK-wide network of hospitals involved in a research collaboration called the OCCAMS consortium. The goal of this project is to use high quality clinical material with accurately annotated clinic-pathological, treatment and outcome data.

Study Datasets 7 datasets.

Click on a Dataset ID in the table below to learn more, and to find out who to contact about access to these data

Dataset ID Description Technology Samples
Illumina HiSeq 2000 29
Samples from Ross Innes et. al 2015 - doi:10.1038/ng.3357
Illumina HiSeq 2000 101
Data supporting: "Low-cost and clinically applicable copy number profiling using repeat DNA." Abujudeh et al. DNA WGS (BAM files) DNA fastSeq (fastq files) Tumours, Barrett's, normals.
Illumina HiSeq 2000,Illumina MiSeq 86
Data supporting: "Genomic evidence supports a clonal diaspora model for metastases of esophageal adenocarcinoma." Noorani et al. WGS (BAM files) 134 samples for 18 cases Includes primary, lymph-node, distant metastatic, Barrett's and normal samples.
Illumina HiSeq 2000 134
Data supporting: "Genomic copy number predicts esophageal cancer years before transformation." Killcoyne et al. sWGS data 1000 samples BAM files
Illumina HiSeq 2500,Illumina HiSeq 4000 1000
Data supporting: "Widespread reorganisation of the regulatory chromatin landscape facilitates resistance to inhibition of oncogenic ERBB2 signalling" Ogden et al. WGS for tumour and normal samples. RNAseq for tumour samples.
HiSeq X Five,Illumina HiSeq 2000 636
Array data for oesophageal and related samples – sj_paper_methyl_barretts_release
Illumina 150

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