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Tubulointerstitial fibrosis is the histological hallmark of chronic kidney disease (CKD). Hypoxia and inflammation (i.e., interleukin (IL)-1β signalling) are independent mediators of tubulointerstitial fibrosis. However, the physiological response of human kidney tubular cells to IL-1β/IL-1RI signalling under the hypoxic conditions of CKD is poorly understood and remains a clinical imperative for therapeutic targeting. This study reports that hypoxia and IL-1β act in synergy to trigger cell cycle arrest/cellular senescence of ex vivo patient-derived primary proximal tubular epithelial cells (PTECs).
Study
EGAS00001007904
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Identification of intronic sequences promoting natural skipping of ABCA4 exon 15 using long-read transcriptomics and midigene assays
Study
EGAS50000000071
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Blueprint Data Access Committee.
Dac
EGAC00001000135
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Integrating molecular imaging and transcriptomic profiling in advanced HER2-positive breast cancer receiving trastuzumab emtansine (T-DM1): an analysis of the ZEPHIR clinical trial
Study
EGAS50000000470
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Genomic Profiling of Pediatric Tumors by Cell Free DNA Sequencing
Study
EGAS50000000072
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Integrative analysis reveals a macrophage-predominant, immunosuppressive immune microenvironment and subtype-specific therapeutic vulnerabilities in advanced salivary gland cancer
Study
EGAS50000000809
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A prospective study identifies MisMatch Repair genes as candidate predisposing genes for uveal melanoma.
Study
EGAS50000000914
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Emirati Genome Project subset of 43,608 WGS samples for population-scale variant discovery and allele frequency mapping.
Study
EGAS50000001071
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Single-Gene vs. Panel Sequencing in Advanced HR+/HER2− Breast Cancer
Study
EGAS00001008200
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CDK4/6 inhibition in advanced chordoma: final results of the NCT PMO-1601
Study
EGAS00001007985
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A circulating biomarker for severity of facioscapulohumeral muscular dystrophy
Study
EGAS00001007350
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First genome-wide association study in an Australian Aboriginal population provides insights into genetic risk factors for Body Mass Index and Type 2 Diabetes
Study
EGAS00001001004
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Nala GSI GSAv3 PGx Study
Study
EGAS00001007710
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mRNA capture sequencing and RT-qPCR for the detection of pathognomonic, novel and secondary fusion transcripts in formalin-fixed paraffin-embedded tissue: a sarcoma showcase
Study
EGAS00001005202
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In this study, blood-brain barrier (BBB)-forming brain endothelial-like cells were generated from apolipoprotein E gene allele E4 (APOE4, high AD risk) and allele E3 (APOE3, lower AD risk) carrying patient-derived induced pluripotent stem cells (iPSCs). Cells were subsequently exposed to focused ultrasound and microbubbles (FUS+MB) to induce BBB opening and their transcriptome analysed. RNA sequencing (RNA-seq) results demonstrated minimal changes in the gene expression following FUS+MB suggesting safety of FUS+MB application in the clinical setting.
Study
EGAS00001005944
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Genomic profiling of paediatric high grade gliomas from the HERBY clinical trial
Study
EGAS00001002328
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High-throughput telomere length measurement at nucleotide resolution using the PacBio high fidelity sequencing platform
Study
EGAS00001006103
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Local In Time Statistics for processual research
Study
EGAS00001002520
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RNAseq data to study PRPF6 regulated splice forms in colon cancer cell lines
Study
EGAS00001000761
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Assessing the impact of low frequency coding variants on disease risk using the Exomechip
Study
EGAS00001000584
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Whole Genome Sequencing of Asian Lung Cancers: Second Hand Smoke is Not Responsible for Higher Incidence of Lung Cancer Among Asian Never-Smokers
Study
EGAS00001000621
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Probabilistic modeling of personalized drug combinations from integrated chemical screen and molecular data in sarcoma
Study
EGAS00001003564
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McGill Epigenomics Mapping Centre
Study
EGAS00001000995
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Polymorphisms in the mitochondrial genome are associated with bullous pemphigoid in Germans
Study
EGAS00001003932
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UK10K COHORT ALSPAC
Study
EGAS00001000090
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Genetic_Heterogeneity_of_the_familial_gastric_neuroendocrine_tumors
Study
EGAS00001002273
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Genome_Diversity_in_Africa_Project__Uganda
Study
EGAS00001002523
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Next-Generation Sequencing of RNA and DNA Isolated from Paired Fresh-Frozen and Formalin-Fixed Paraffin-Embedded Samples of Human Cancer and Normal Tissue
Study
EGAS00001000737
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Dynamics of multiple resistance mechanisms in plasma DNA and their clinical implications for NSCLC patients receiving EGFR-targeted therapies
Study
EGAS00001002908
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Population Structure and Genetic Diversity in Argentinean populations
Study
EGAS00001001663
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Copy number profiling of primary samples and cell lines of retinoblastoma
Study
EGAS00001001715
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NEOPREDICT-Lung: Neoadjuvant Immunotherapy for Resectable NSCLC
Study
EGAS00001007753
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The G2 gene expression signature and MYC overexpression are independent poor prognostic factors in childhood high-grade osteosarcoma
Study
EGAS00001008073
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Whole exome and RNA sequencing of organoid samples derived from TRACERx patients
Study
EGAS00001008092
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Raw bulk TCRseq data fromTIL and non-TIL expanded TRACERx samples in the manuscript Bulk TCRseq from TRACERx samples from 'Subclonal immune evasion in non-small cell lung cancer'
Study
EGAS00001008118
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Successful immune checkpoint blockade in a patient with advanced stage microsatellite unstable biliary tract cancer (H021)
Study
EGAS00001002441
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Exome Sequencing to Define the Landscape of Plasma Cells in Systemic Light chain Amyloidosis
Study
EGAS00001001418
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H3Africa - Genomic and Environmental Risk Factors for Cardiometabolic Disease in Africans
Study
EGAS00001002482
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UK10K_NEURO_ASD_FI
Study
EGAS00001000110
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Liver biopsy derived induced pluripotent stem cells provide an unlimited supply for the generation of patient-specific hepatocyte-like cells
Study
EGAS00001002676
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Characterization of genetic intratumor heterogeneity in colorectal cancer and matching patient-derived spheroid cultures.
Study
EGAS00001002684
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Intra-tumor heterogeneity of localized lung adenocarcinomas defined by multi-region sequencing
Study
EGAS00001000930
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Exploration of CNV’s and SNV’s in cancers with well-known genetic rearrangements: Identification of additional genetic changes in rearrangements-driven cancer
Study
EGAS00001000673
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Whole exome sequencing of germline DNA was performed and subsequent polymorphisms in genes known and putatively involved in the innate immune response to fungi were identified
Study
EGAS00001001542
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Bulk-RNA Sequencing of high-grade pancreatic and non-pancreatic Neuroendocrine Neoplasms
Study
EGAS00001004861
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Molecular Tumor Board to Inform on Personalized Medicine for a Man with Advanced Prostate Cancer
Study
EGAS00001004648
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Genetic analysis of HLA and immune escape genes in Diffuse Large B-cell Lymphoma
Study
EGAS00001005054
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Same-day genomic and epigenomic diagnosis of brain tumors using realtime nanopore sequencing
Study
EGAS00001002213
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Deep single-cell RNA sequencing data for 11138 T cells from tumour, adjacent normal tissue and peripheral blood of treatment-naive CRC patients. The DATA ACCESS AGREEMENT is provided at https://github.com/zhangyybio/single-T-cell-data-access. Applicants can request access to the data by directly downloading it or by sending an email to cancerpku@pku.edu.cn. The process that is used to approve an application includes verifying the institution, participants and research purposes of the application. In general this process will take about two weeks. In principal, any scientific research program complying with the laws and bioethic regulation policies of China will be approved.
Study
EGAS00001002791
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WES_of_adult_intellectual_disabilities_with_co_morbid_psychiatric_disorders
Study
EGAS00001002962