14662 results for "PLOS+ONE+Pennsylvania+German+ACS+language+code+pdc+open+access+study"

in 23.73 milliseconds.

• Single-cell TCR sequencing of DQ2.5-hor-3-specific T cells

  Study EGAS00001003674

• Enhancer-gene rewiring in the pathogenesis of Quebec Platelet Disorder

  Study EGAS00001004315

• single-cell RNA-Seq of colorectal cancer patient samples

  Study EGAS00001006665

• Accelerated single cell seeding in relapsed multiple myeloma

  Study EGAS00001004404

• Whole-genome sequencing of lymphomas in immune-privileged sites

  Study EGAS00001005367

• Cell of Origin and Early Evolution of Leukemia in Down Syndrome

  Study EGAS00001004780

• AUBTRG - Whole Exome Sequencing of Diffuse Glioma Samples

  Study EGAS00001003035

• Single cell sequencing data from Shwachman-Diamond syndrome bone marrow

  Study EGAS00001004881

• Molecular analysis of inflammatory myofibroblastic tumor (WGS and WES)

  Study EGAS00001005081

• Microbiota, Appetite, and Malnutrition in Dutch Community-dwelling older adults

  Study EGAS00001005319

• Multipolar zygotic divisions are characterized by parental genome segregation errors

  Study EGAS00001005543

• Molecular characterization of a renal cell carcinoma PDX cohort

  Study EGAS00001006249

• Validation of a targeted sequencing panel for multiple myeloma

  Study EGAS00001006164

• The admixture histories of Cabo Verde

  Study EGAS00001006348

• RNAseq analysis on primary sites Colorectal Cancer xenografts (PRX) samples

  Study EGAS00001007051

• Human subsistence and signatures of selection on chemosensory genes

  Study EGAS00001007307

• Somatic mutations associate with clonal expansion of CD8+ T cells

  Study EGAS00001007606

• Genetic Effects on the Skin Methylome in Healthy Older Twins

  Study EGAS00001007816

• Characterization of alternative promoter usage in advanced prostate cancer

  Study EGAS00001006275

• NGS based Aspergillus detection in liquid biopsies of immunocompromised patients

  Study EGAS00001008021

• GBM stem cell lines and PRMT5 inhibitor

  Study EGAS00001004397

• Mevalonate Metabolism fuels pro-inflammatory function of Vd2 T cells

  Study EGAS00001007530

• Elucidating the molecular landscape of KRAS/BRAF mutant colorectal cancers

  Study EGAS00001007459

• Spatial Deconvolution of HER2-positive Breast Tumors

  Study EGAS00001005577

• Aberrant EZHIP Expression Drives Tumorigenesis in Osteosarcoma

  Study EGAS00001007531

• Total proteome and phosphoproteome profiling of Diffuse Midline Glioma

  Study EGAS00001007341

• Papua New Guinean Genome Altitude Project

  Study EGAS00001007085

• Integrated genetic analysis of primary CNS lymphoma

  Study EGAS00001007222

• Fasting-mimicking diet reshapes antitumor immunity in cancer patients

  Study EGAS00001004944

• Transcriptome_analysis_of_anaplastic_meningiomas

  Transcriptome of anaplastic meingiomas

  Study EGAS00001001873

• WES

  Whole exome sequencing of UTUC

  Study EGAS00001004415

• MicroRNAs signatures from CSF extracellular vesicles of Parkinson’s Disease patients

  Study EGAS00001004830

• Comparison of the performance of two commercial genome-wide association study genotyping platforms in Han Chinese Samples

  Affymetrix 6.0, Illumina OMNIExpress, and llumina Immunochip genotype data for Han Chinese population including rheumatoid arthritis cases and controls. Data is in PLINK binary format. Illumina genotype clustering was performed using Illumina’s BeadStudio software. SNPs were reclustered using the study samples, low quality subjects were removed, and a subset of clustering results were manually inspected and verified. All SNPs with GenCall scores less than 0.15 were excluded. For Affymetrix chips, clustering was performed using the program Birdseed version 2, as implemented using Affymetrix Genotyper Console v4.0, using the default quality control (QC) thresholds.

  Study EGAS00000000131

• Genetics of Pigmentation in Eastern and Southern African Populations Study

  The goal of this study was to identify genes and loci associated with pigmentation in African populations. It comprises 1,593 participants from Ethiopia, Tanzania, and Botswana. Sexes are evenly represented (768 males and 825 females) and self reported ages ranged from 18 to 103. Mean age was used for individuals without ages. For each participant, a DSM II color meter was used to measure underarm skin reflectance in triplicate. These measures averaged and converted to a melanin index (MI = 100 x log10(1/(x/255)). All individuals were included in a genome wide scan that accounted for age, sex, and genetic relatedness.

  Study phs001396

• A Phase I/IB Study of Ipilimumab or Nivolumab in Patients With Relapsed Hematologic Malignancies After Allogeneic Hematopoietic Cell Transplantation

  Relapse after allogeneic hematopoietic stem cell transplantation (HSCT) is characterized by poor outcomes and novel therapeutic options are urgently needed. Immune checkpoint blockade using CTLA-4 and PD-1 blocking antibodies are a potential concept for reinstating a dormant graft-versus-leukemia (GvL) effect.This study investigated transcriptomic changes in biopsies obtained from patients who received immune checkpoint blockade for relapsed hematologic malignancy post-HSCT and elucidated transcriptional programs associated with successful reinvigoration of GvL. Differential gene expression analysis showed evidence of increased T cell infiltration in biopsies of responders to ipilimumab treatment and demonstrated shared gene programs between GvL and GvHD.

  Study phs002377

• My Pediatric and Adult Rare Tumor (MyPART) Natural History Study of Rare Solid Tumors

  The goal of this study is to comprehensively and longitudinally evaluate the natural history of patients with rare solid tumors or tumor predisposition syndromes, estimating and defining their clinical spectrum (e.g. disease course and survival). Clinical data, patient reported outcomes (PROs), and biospecimen associated data are collected. Clinical data includes response to treatment, tumor pathology, and imaging. PROs include measures of pain, depression, anxiety, mobility, and cognitive functioning. Biospecimen data includes next-generation sequencing [RNAseq, whole exome sequencing (WES), whole genome sequencing (WGS), EPIC methylation array data, and TruSight Oncology 500 gene panel sequencing], cytokine analysis of plasma, immune phenotyping of circulating peripheral blood mononuclear cells.

  Study phs003143

• Whole-genome variant calling of individuals from the study of allergic diseases in the Canary Islands

  Research study of genetic susceptibility and analyses of polygenic risk scores in allergic diseases. The historic influences in the Canary Islanders have resulted in an admixture of European, North Africans and Sub-saharan African genetic ancestries. Genetic risks linked to any of these ancestries could underlie disease peculiarities in the current inhabitants. To leverage genectic ancestry to identify and assess genetic risks in allergic diseases in the Canary Islands, we combine different genomic technologies in case-control studies and reference samples from the three parental populations to characterize and identify genetic risks factors and the intersection with ancestry.

  Study EGAS50000000299

• Circulating cell-free DNA methylation profiles as noninvasive multiple sclerosis biomarkers: A proof-of-concept study

  In chronic neurodegenerative diseases such as multiple sclerosis (MS), there is a critical unmet need for cost-effective non-invasive blood biomarkers to concurrently classify disease subtypes, monitor disability severity, and predict long-term progression. In this proof-of-concept study, we performed low-coverage whole-genome bisulfite sequencing (WGBS) on 75 plasma cell-free DNA (cfDNA) samples collected from a well-characterized real-world prospective clinic cohort with longitudinal disability outcome measurements. We assessed the clinical utility of cfDNA methylation profile for differentiating MS patients from non-MS controls, classifying MS subtypes, estimating disability severity, and predicting disease trajectories.

  Study EGAS50000001277

• Mapping_regulatory_variation_in_sensory_neurons_using_IPS_lines_from_the_HIPSCI_project

  Sensory neurons are nerve cells that are activated by sensory input such as heat, light and convey information to the brain. Although a key cell type in complex organisms, human sensory neurons are challenging to study because they are impossible to obtain from living donors. We have collaborated with the Neucentis Pharmaceutical Research Unit to differentiate sensory neuron like cells from human induced pluripotent stem cells derived as part of the Human Induced Pluripotent Stem Cells Initiative. We will sequence RNA from 100 IPS lines derived from healthy individuals and perform RNA-seq on the differentiated cells to identify noncoding variants that alter gene expression in human sensory neurons.

  Study EGAS00001001149

• Feasibility Study to Identify the Optimal Adjuvant Combination Scheme of Ipilimumab and Nivolumab (OpACIN) in resectable stage III melanoma patients

  OpACIN is a feasibility study including 20 patients with palpable stage III melanoma that were 1:1 randomized to receive ipilimumab 3mg/kg and nivolumab 1mg/kg, either 4 courses after surgery (adjuvant arm), or 2 courses prior to surgery and 2 courses post-surgery (neoadjuvant arm). WES and RNA-seq was performed on baseline biopsy material and correlated with outcome of the patients (relapse free survival). TCRseq from baseline tumor samples was used to analyse the top 100 tumor resident clones and analyse their change in PBMC comparing baseline versus week 6 of immunotherapy.

  Study EGAS00001003099

• Molecular profiling of longitudinally observed small colorectal polyps: a cohort study

  Knowledge of the natural history of colorectal adenomas is limited because these lesions are removed upon detection. The few studies in which small adenomas have been left in situ for a limited period of time have shown that most lesions remain stable or even completely vanish. Lesions that have grown in size more often turn out to be advanced adenomas when resected. Specific DNA copy number changes (cancer associated events or CAEs) are associated with progression of adenomas to cancer. The aim of the study was to evaluate whether growth of small colorectal polyps left in situ is associated with specific molecular features.

  Study EGAS00001003284

• CASCADE metastatic melanoma study

  In this study we analyse the evolution of human melanoma from early to late disease in patients by sampling their tumours at multiple sites and times. Whole exome and genome sequencing data from tumour samples reveals only limited gain of point mutations generally, with net mutational loss in some metastases. In contrast, melanoma evolution is dominated by whole genome doubling and large-scale aneuploidy, in which widespread loss of heterozygosity sculpts the burden of point mutations, neoantigens and structural variants even in treatment-naïve and primary cutaneous melanomas in some patients. These results imply that dysregulation of genomic integrity is a key driver of selective clonal advantage during melanoma progression.

  Study EGAS00001004950

• Dataset of Sarcopenia HNSCC

  For this study, we compared the transcriptome of samples exposed to the influence of the FaDu cells (N=6) vs in the control condition (N=2). Muscle fragments were collected intraoperatively from patients with HNSCCs (N=9). The collection of these samples was made possible as part of an ancillary study linked to the Magnolia clinical trial (NCT 04842162). These fragments most often came from the sternocleidomastoid muscle.

  Dataset EGAD50000000944

• Phenotype, genotype, and transcriptome data from three South Eastern Bantu groups in the SABR study

  Phenotypic data, whole genome sequencing, blood RNA-seq, imputed variant calls, cell type estimates, gene expression levels, splicing measurements, and analysis covariates from South African Blood Regulatory (SABR) resource participants, which includes South Eastern Bantu-speaking groups.

  Dataset EGAD50000001477

• RODAM

  The RODAM study assesses the health and wellbeing of Ghanaian residents in Ghana and Europe and follows them up over time. With this unique approach the RODAM study attempts to unravel the causes of cardiovascular disease and its risk factors among African migrants in Europe and non-migrants sub-Saharan Africa. Data are available upon reasonable request. These requests can be made to de RODAM-Pros cohort coordinator (rodamcoordinator@amsterdamumc.nl) or principal investigator, Professor Charles Agyemang (c.o.agyemang@amsterdamumc.nl).

  Dac EGAC50000000474

• Whole Genome Sequencing of INTERVAL (2019-06-12)

  15x Whole Genome Sequencing of 15,000 individuals from the INTERVAL study cohort, phase III. This data is part of a pre-publication release. For information on the proper use of pre-publication data shared by the Wellcome Trust Sanger Institute (including details of any publication moratoria), please see http://www.sanger.ac.uk/datasharing/ . This dataset contains all the data available for this study on 2019-06-12.

  Dataset EGAD00001005086

• Whole-transcriptome sequencing of hepatocellular carcinoma biopsies (TACE study)

  We performed a transcriptomic analysis of hepatocellular carcinomas (HCCs) and paired non-tumor biopsies to identify predictive biomarkers for response to transarterial chemoembolization (TACE). We identified several transcripts which are predictive of response to TACE.

  Study EGAS00001005558

• RNA-seq dataset of Oncogenic and immunological targets for matched therapy of pediatric blood cancer patients: Dutch iTHER study experience

  RNA-seq dataset of Oncogenic and immunological targets for matched therapy of pediatric blood cancer patients: Dutch iTHER study experience

  Dataset EGAD00001015639

• Whole Genome Sequencing of Human Organoid Lines (2020-02-20)

  The study will use WGS to aid in benchmarking different culture conditions in a set of genetically annotated human organoid lines. The data will be used to assess whether there is any clonal differences introduced when culturing these lines in different conditions. . This dataset contains all the data available for this study on 2020-02-20.

  Dataset EGAD00001005995

• Reconstruction of human terminal erythroid differentiation cell at single cell level

  Study EGAS00001003114

• Quantitative analysis of a novel DNA hypermethylation panel for lung cancer diagnosis

  Study EGAS00001007008

• DAC for study Screening for abnormal CGI methylation in primary colorectal tumours

  Dac EGAC00001000069

• MeDIP-seq data in the Peri/postnatal Epigenetics Twins Study (PETS)

  Dac EGAC00001000596

• The APL DAC comprises a clinician and biologist who conducted the study.

  Dac EGAC00001000865

• DAC for the study of tumor-derived somatic mutation detection in cfDNA

  Dac EGAC00001001569

• Finland Myoma Study

  Dac EGAC00001002131

• EXCEED Study genotypes

  EXCEED genotyping

  Dataset EGAD00010001699

• Rapid, economical diagnostic classification of ATRT molecular subgroup using NanoString nCounter platform

  Study EGAS00001007470

• Gene expression profiling of HGCC patient-derived Glioblastoma Cell Lines (ISPA-GBM)

  Study EGAS00001006814

• Targeted sequencing of 13131 older individuals, using 750-gene panel

  Study EGAS00001005316

• The effects of inhaled corticosteroids on healthy airways

  Study EGAS00001007538

• Panic study

  To manage Panic saliva microbiota 16S data produced in collaboration.

  Dac EGAC50000000408

• Whole genome sequencing of matched primary and metastatic acral melanomas

  Study EGAS00001000169

• A Comprehensive Catalogue of Somatic Mutations from a Human Cancer Genome

  Study EGAS00001000245

• Diagnostic Exome Sequencing in Persons with Severe Intellectual Disability

  Study EGAS00001000287

• Whole exome sequencing of virus-associated HCC

  Study EGAS00001000389

• Mitochondrial DNA (mtDNA) analyses in patients with schizophrenia and healthy control individuals

  Study EGAS00001003269

• Mechanisms of active DNA demethylation in human monocytes

  Study EGAS00001004784

• ATAC-Seq and CTCF ChIP-Seq on the OCIAML-2 cell line

  Study EGAS00001004741

• Characterization of human iPSC-derived dopaminergic neurons with 16p11.2 CNVs

  Study EGAS00001005137

• TULIPs decorate the three-dimensional genome of PFA ependymoma

  Study EGAS00001005476

• Single-cell TCR sequencing of DQ2.2-glut-L1-specific T cells

  Study EGAS00001003673

• Targetable ERBB2 Mutations in Neurofibroma/Schwannoma Hybrid Nerve Sheath Tumors

  Study EGAS00001003776

• RNA_Seq on Human CB-derived LT-HSC with shCTCF or control vector

  Study EGAS00001004745

• Peripheral clonal expansion of T cells (scRNA-seq)

  Study EGAS00001003993

• Activating AKT1 and PIK3CA mutations in metastatic castration-resistant prostate cancer

  Study EGAS00001004328

• CD27hiCD38hi plasmablasts are activated B cells of mixed origin with distinct function

  Study EGAS00001005258

• Atrial appendage miRNA-seq in non-, paroxysmal and persistent atrial fibrillation

  Study EGAS00001005296

• Human gut microbiome in babies with biliary atresia and normal controls

  Study EGAS00001005350

• RNAseq from regions of insitu and invasive human mammary ductal disease

  Study EGAS00001005370

• Evidence that ciliary genes contribute to non-syndromic familial tall stature

  Study EGAS00001005372

• PIK3CA mutation in a case of CTNNB1 mutant sinonasal glomangiopericytoma

  Study EGAS00001005653

• A critical spotlight on the paradigms of FFPE-DNA sequencing

  Study EGAS00001005757

• Optimisation of CITE-seq on liquid and solid tissues

  Study EGAS00001005849

• Molecular analysis in bowel malignancies in cancer survivors vs. primary malignancies

  Study EGAS00001005940

• Oesophageal adenocarcinoma whole exome and RNA-seq raw sequencing data

  Study EGAS00001005957

• DNA methylation profiles of samples included in the EORTC 26091 TAVAREC trial

  Study EGAS00001006015

• RNAseq analysis on metastatic Colorectal Cancer xenografts samples

  Study EGAS00001006492

• Quantitative Exploratory Proteomics Analysis of Glioblastoma in Initial and Recurrent Tumors

  Study EGAS00001006395

• Sequencing Data of HGSC patient-derived cell lines and organoids

  Study EGAS00001006557

• Treated and control Patient Derived Xenografts of colorectal cancer (CRC) samples

  Study EGAS00001006973

• VRK3 depletion in Pontine Diffuse Midline Glioma (DMG)-K27 altered cells

  Study EGAS00001007047

• Single cell landscape of Multicentric Castleman Disease in monozygotic twins

  Study EGAS00001007390

• Advanced iPSC-CMs maturation by integrating maturation medium, nanopatterning, and electrical stimulation

  Study EGAS00001007491

• RNA sequencing of control OM cells exposed to traffic-related air pollutants

  Study EGAS00001007528

• Measuring the Efficiency of Purging by Nonrandom Mating in Human Populations

  Study EGAS00001007831

• RNA Sequencing of paediatric patients with B lymphoblastic leukemia

  Study EGAS00001003726

• Array-based methylation analysis of SDHB-deficient pheochromocytoma and paraganglioma

  Study EGAS00001007844

• Myeloid cell programming in patients with non-medullary thyroid carcinoma

  Study EGAS00001005594

• Population Genomics of Native Americans from Andes and Amazon

  Study EGAS00001004639